Chloe Lopez-Lee
@chloelopezlee.bsky.social
🧠 postdoc @sinaibrain.bsky.social studying how sex modulates immune-vascular crosstalk during #Alzheimers in the Elahi lab | '21 HHMI Gilliam fellow | 🇵🇷 🇰🇷
Reposted by Chloe Lopez-Lee
I am thrilled to announce that I will be starting my lab at
@washumedicine.bsky.social, Department of Pathology & Immunology as an Assistant Professor this month. The lab will study the role of innate immunity in neurodegeneration and brain aging. We'll be hiring at all levels. Details soon!
@washumedicine.bsky.social, Department of Pathology & Immunology as an Assistant Professor this month. The lab will study the role of innate immunity in neurodegeneration and brain aging. We'll be hiring at all levels. Details soon!
July 1, 2025 at 6:56 PM
I am thrilled to announce that I will be starting my lab at
@washumedicine.bsky.social, Department of Pathology & Immunology as an Assistant Professor this month. The lab will study the role of innate immunity in neurodegeneration and brain aging. We'll be hiring at all levels. Details soon!
@washumedicine.bsky.social, Department of Pathology & Immunology as an Assistant Professor this month. The lab will study the role of innate immunity in neurodegeneration and brain aging. We'll be hiring at all levels. Details soon!
Reposted by Chloe Lopez-Lee
"A rare genetic mutation known as APOE3-R136S, or the “Christchurch mutation,” appears to protect against #AlzheimersDisease by suppressing inflammatory signaling in the brain’s immune cells."
Learn More in Immunity @cellpress.bsky.social
www.cell.com/immunity/abs...
Learn More in Immunity @cellpress.bsky.social
www.cell.com/immunity/abs...
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The APOE3 Christchurch mutation (R136S) reduces tau pathology despite the PSEN1 mutation
and high amyloid, though its protective mechanism remains unclear. Naguib et al. show
that R136S suppresses mic...
www.cell.com
June 25, 2025 at 11:50 AM
"A rare genetic mutation known as APOE3-R136S, or the “Christchurch mutation,” appears to protect against #AlzheimersDisease by suppressing inflammatory signaling in the brain’s immune cells."
Learn More in Immunity @cellpress.bsky.social
www.cell.com/immunity/abs...
Learn More in Immunity @cellpress.bsky.social
www.cell.com/immunity/abs...
Reposted by Chloe Lopez-Lee
My postdoc work from the Gan Lab is out now! 👇
The incredible @sarahnaguib.bsky.social and @chloelopezlee.bsky.social drove this project to completion and I'm so proud of the work put in and grateful to all the contributions from Gan lab members and collaborators. 🧠
The incredible @sarahnaguib.bsky.social and @chloelopezlee.bsky.social drove this project to completion and I'm so proud of the work put in and grateful to all the contributions from Gan lab members and collaborators. 🧠
🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…
www.sciencedirect.com
June 25, 2025 at 1:48 AM
My postdoc work from the Gan Lab is out now! 👇
The incredible @sarahnaguib.bsky.social and @chloelopezlee.bsky.social drove this project to completion and I'm so proud of the work put in and grateful to all the contributions from Gan lab members and collaborators. 🧠
The incredible @sarahnaguib.bsky.social and @chloelopezlee.bsky.social drove this project to completion and I'm so proud of the work put in and grateful to all the contributions from Gan lab members and collaborators. 🧠
Grateful for the opportunity to co-lead this study with @liganlab.bsky.social, @sarahnaguib.bsky.social, and @ertorres.bsky.social! We peel back layers of the protective Christchurch mutation to identify underlying mechanisms and transfer protection to non-Christchurch models with neurotoxic tau 💫
🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…
www.sciencedirect.com
June 25, 2025 at 2:09 AM
Grateful for the opportunity to co-lead this study with @liganlab.bsky.social, @sarahnaguib.bsky.social, and @ertorres.bsky.social! We peel back layers of the protective Christchurch mutation to identify underlying mechanisms and transfer protection to non-Christchurch models with neurotoxic tau 💫
Reposted by Chloe Lopez-Lee
🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…
www.sciencedirect.com
June 24, 2025 at 12:58 PM
🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...
Reposted by Chloe Lopez-Lee
And the full paper is here - www.pnas.org/doi/abs/10.1....
Thanks to Dave and Joseph for the nice coverage!
Thanks to Dave and Joseph for the nice coverage!
April 9, 2025 at 12:01 AM
And the full paper is here - www.pnas.org/doi/abs/10.1....
Thanks to Dave and Joseph for the nice coverage!
Thanks to Dave and Joseph for the nice coverage!