Will Chen
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chenomics.bsky.social
Will Chen
@chenomics.bsky.social
120 followers 96 following 3 posts
@damonrunyon.org Fellow at Baker lab @uwproteindesign.bsky.social. PhD with @jshendure.bsky.social. A genomicist with a biophysical lens. Genomic technology developer.
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Reposted by Will Chen
troymcdiarmid.bsky.social
Our work developing a parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording is now out @natbiotech.nature.com
November 12, 2025 at 6:06 PM
chenomics.bsky.social
Molecular recording is a exciting and rapidly evolving field. In this perspective, @choijunhong.bsky.social and I delve into the key challenges in the field and highlight a few exciting frontiers that worth more attention.
cp-trendsgenetics.bsky.social Trends in Genetics @cp-trendsgenetics.bsky.social · May 6
Online now -- a new Review:

"Molecular circuits for genomic recording of cellular events"
by Wei Chen & Junhong Choi (@choijunhong.bsky.social)

FREE to read till June 25th using this link:
authors.elsevier.com/a/1l2gMcQbJF...
Figure 1. Reconstructing cell signaling history with genomic recording circuits. (A) Concept overview: cellular signals (e.g., environmental changes, signaling molecules, or cell–cell interactions) are converted into genomic recordings via event sensors in each cell. Recorded information is retrieved through sequencing assays to reconstruct each cell’s signaling history and its role in cell fate decisions. (B) Key advancements enabling genomic recording: the discovery of CRISPR-Cas9 provided precise, programmable genome editing. Single-cell profiling methods facilitated the accurate retrieval of genomic recordings. Advances in protein design and synthetic biology are transforming the development of cellular event sensors for genomic recording.
May 6, 2025 at 7:29 PM
Reposted by Will Chen
seidels.bsky.social
Interested in #Bayesian #phylogenetics? 🧬
Join the Taming the BEAST workshop — theory + hands-on tutorials incl. #singleCell, #devBio & #lineageTracing!
📍Beijing, July 14–18, 2025
📅 Apply by April 25
I'll teach on TiDeTree & cell trees
🔗 taming-the-beast.org/news/Deadlin...
Application deadline extended for Taming the BEAST in Beijing!
taming-the-beast.org
April 17, 2025 at 7:28 PM
Reposted by Will Chen
vram142.bsky.social
The latest from our group, led by Megan Ostrowski and @martyyang.bsky.social, is now published in final form (www.cell.com/cell/fulltex...! Many thanks to our excellent peer reviewers for suggesting several experiments (including CAF-1 perturbation) to really improve the study =) #epigenetics
The single-molecule accessibility landscape of newly replicated mammalian chromatin
By developing a long-read sequencing method to simultaneously map replication status and protein-DNA contacts in cells, Ostrowski, Yang, et al. show that newly replicated chromatin is enriched for unw...
www.cell.com
November 15, 2024 at 3:35 PM
chenomics.bsky.social
Another Monday hype! super excited to see the review + DNA Typewriter/ENGRAM got covered in this nice story.
carlzimmer.com Carl Zimmer @carlzimmer.com · Nov 25
Imagine a mouse in which all 10 billion cells keep a diary from fertilization. Imagine sentinel cells recording your experiences and sending out dispatches in the form of DNA. Here's a story I wrote about cell recorders 🧪 Gift link: nyti.ms/3Z3Mqza
‘DNA Typewriters’ Can Record a Cell’s History
Labs around the world are trying to turn cells into autobiographers, tracking their own development from embryos to adults.
nyti.ms
November 26, 2024 at 1:31 AM
Reposted by Will Chen
elowitzlab.bsky.social
"The lives of cells, recorded"--our new review on genomic recording systems and how they can reveal the dynamics of multicellular development. A pleasure to work on this with amazing colleagues from the Allen Discovery Center for Cell Lineage Tracing.
www.nature.com/articles/s41...
The lives of cells, recorded - Nature Reviews Genetics
Recent advances in genome engineering are enabling the recording of cellular histories into genomes, with single-cell and spatial omics technologies enabling their reconstruction into cellular lineage...
www.nature.com
November 25, 2024 at 5:29 PM