We brought together 22 researchers & 6 experts for a full day of evaluating GPCR and ion channel probes — and completed 26 reviews!
Lots of learning, laughter, and deep discussions about what makes a great chemical probe.

#ChemicalProbes #OpenScience #DrugDiscovery #GPCR #IonChannels

We’re in Oxford today for the 1st UK Chemical Probes Hackathon! 🎯
Postdocs & PhD students join experts to assess GPCR probes and improve research quality.
Hosted by @ChemProbes + @UniofOxford
#ChemicalProbes #GPCRs #DrugDiscovery

🚀 On July 21, the Chemical Probes Portal celebrates 10 years! Launched after the landmark 2015 @NatChemBio paper by Arrowsmith et al., it now features >1150 compounds, >600 targets, and 1600+ expert reviews—powering better biomedical research. 🧪🔬
👉 chemicalprobes.org #ChemicalBiology @icr.ac.uk

🏅 Also, congratulations to Professor Workman on being inducted into the AACR Academy — a wonderful recognition of his contributions to cancer research.
(Photos below from the AACR Academy Award Ceremony.)

#AACR2025 #CancerResearch #DrugDiscovery #PrecisionOncology #PersonalizedMedicine

Reminder: Tomorrow, Professor Paul Workman will give his Meet the Expert Lecture at #AACR:
Personalized Molecular Medicine Enabled by Multidisciplinary Approaches to Cancer Drug Discovery and Clinical Development.
Details: www.abstractsonline.com/pp8/#!/20273...
#AACR2025 #CancerResearch

📢Looking ahead to #AACR25 in Chicago — only 6 weeks away!

Join the Meet-the-Expert session with Prof. Paul Workman, where he’ll emphasize the critical role of high-quality chemical probes in drug discovery.

📅 April 29, 2025 | ⏰ 5:00-5:45 PM
Learn more👇

#CancerResearch

The Chemical Probes Portal now covers 601 protein targets, expanding resources for chemical biology & drug discovery! 🧪🔬 New high-quality probes target DCTPP1, MASTL, HCN1, plus E3 ligases & PROTACs for protein degradation. Learn more: www.chemicalprobes.org/news/600-tar... #ChemicalProbes

Our Cancer Cell Commentary reviews progress on chemical probes since Arrowsmith et al. (Nat Chem Biol 2015) and the launch of the Chemical Probes Portal. We highlight key issues, propose solutions, and outline a path to a quality probe for every human protein. #ChemicalProbes

🔬 The Chemical Probes Hackathon is underway in Vienna!

Experts from academia & industry, along with international students, are reviewing kinase inhibitors & PROTACs—advancing biomedical research through collaboration.

Excited to see today’s findings! 🚀 #EUFEPS #chemicalprobes

🔬 Calling all PhD students & postdocs in chemistry/biology!
Join us at the Chemical Probes Hackathon 🧪:

🗓️ Feb 20, 2025 | 10:00–14:30
📍 Vienna, Austria

💡 Evaluate chemical probes w/ experts & improve global science 🌍.
🎓 Earn a Certificate of Attendance!

Learn more & register 👇

Season’s Greetings and Best Wishes for 2025 from the Chemical Probes Portal! ✨🔬

🌟 Exciting news! Introducing #MAINFRAME, a global #OpenScience network uniting #MachineLearning & #CompChem experts to drive innovation in #DrugDiscovery. 🚀
Their mission? Open-source algorithms, real-world benchmarking, and faster, affordable medicine development.
Learn more👇

Paul Workman, Sharad Verma, Timothy A. Yap, and Jerome Mettetal discussed "Developing Efficacious Drugs with Better Combinability" in a plenary session at the AACR Conference on Optimizing Therapeutic Efficacy and Tolerability through Cancer Chemistry. #AACRchem24 #AACRCICR

Paul Workman highlighted the importance of selectivity towards the protein target of interest – both for modern, molecularly-targeted drugs and also for high-quality chemical probes for use in laboratory exploration of protein function. #AACRchem24
@icrlondon.bsky.social
@mdanderson.bsky.social

🚨 Just Launched! Episode 1 of the Target 2035 Podcast Series 🎧
Join @LabScribbles as they chat with @CherylArrowsmi1, a trailblazer in chemical biology and co-founder of #Target2035. Discover the story behind this ambitious initiative for #OpenScience and #DrugDiscovery.
🎙️ Listen now: Link below 👇