Manfred Jung
@chemepi.bsky.social
Medicinal Chemist, Prof. @uni-freiburg.de, Chemical Epigenetics www.jungm.de
Hobby Chef #ChemistsWhoCook
Hobby Chef #ChemistsWhoCook
Pomme, was wolle...
November 9, 2025 at 1:37 PM
Pomme, was wolle...
Freiburg 4 Grad. War nicht laufen, aber Kaffir Limette reingeholt.
November 5, 2025 at 7:06 AM
Freiburg 4 Grad. War nicht laufen, aber Kaffir Limette reingeholt.
Special thanks to first author Florian Friedrich but of course everybody else involved www.linkedin.com/posts/floria...
From Pharmacophore to Warhead: NAD+‐Targeting Triazoles as Mechanism‐Based Sirtuin Inhibitors | Florian Friedrich
You might know 1,2,3-triazoles as stable, “chemically inert” linkers or scaffolds widely used in medicinal chemistry. Then you may be surprised to read our latest publication in Angewandte Chemie!
We...
www.linkedin.com
November 2, 2025 at 1:26 PM
Special thanks to first author Florian Friedrich but of course everybody else involved www.linkedin.com/posts/floria...
This may have implications for other NAD dependent enzymes with ADP ribosyltransferase activity @angewandtechemie.bsky.social Thanks @dfg.de for funding. 3/
November 2, 2025 at 1:24 PM
This may have implications for other NAD dependent enzymes with ADP ribosyltransferase activity @angewandtechemie.bsky.social Thanks @dfg.de for funding. 3/
We call these mechanism based sirtuin inhibitors SirTraps that trap the enzyme via this ADP ribose adduct onlinelibrary.wiley.com/doi/10.1002/... 2/
From Pharmacophore to Warhead: NAD+‐Targeting Triazoles as Mechanism‐Based Sirtuin Inhibitors
We report “Sirtuin Trapping Ligands” (SirTraps), mechanism-based 1,2,3-triazole inhibitors that hijack sirtuin (SIRT) catalysis to form covalent triazolium– or triazole–ADP-ribose (ADPR) adducts from...
onlinelibrary.wiley.com
November 2, 2025 at 1:20 PM
We call these mechanism based sirtuin inhibitors SirTraps that trap the enzyme via this ADP ribose adduct onlinelibrary.wiley.com/doi/10.1002/... 2/
Forgot the picture...
October 17, 2025 at 7:23 PM
Forgot the picture...
And afterwards Haselnusskranz (Roll rather) with Espresso Martini
October 17, 2025 at 7:22 PM
And afterwards Haselnusskranz (Roll rather) with Espresso Martini
The sauce was unbelievable, great indeed
October 17, 2025 at 7:08 PM
The sauce was unbelievable, great indeed
A penny for your thoughts !
October 13, 2025 at 10:11 PM
A penny for your thoughts !
Muss los morgen dann...
October 12, 2025 at 4:50 PM
Muss los morgen dann...
Wie heißt dieses Versmaß?
October 12, 2025 at 4:46 PM
Wie heißt dieses Versmaß?
Flask submerged in waterbath
October 12, 2025 at 4:42 PM
Flask submerged in waterbath