The first total synthesis of ansatrienol K, a novel trienomycin congener featuring a diene moiety within its 19-membered macrolactam ring, is reported. Key steps include two sequential palladium-catalyzed cross-coupling reactions for constructing the trisubstituted benzene ring and two distinct strategies for assembling the C6–C18 fragment. A Co2(CO)8-catalyzed carbonylative epoxide ring-opening provided the diene fragment, while late-stage Stewart–Grubbs catalyst-mediated diene-ene ring-closing metathesis (RCM) enabled efficient macrocyclization.

A novel catalytic enantioselective α-ethynylation of oxindoles is realized by virtue of spiropyrrolidine amide (SPA)-triazolium organocation catalysis. Taking advantage of this methodology and develo...

A structurally distinct glycopeptide, saarvienin A, represents a new family of glycopeptide antibiotics consisting of five sugar/aminosugar units connected to a halogenated peptide core. Saarvienin A...

Method creates two new rings and four new bonds

The development of targeted protein degradation by recruiting a protein of interest to a ubiquitin ligase to facilitate its degradation has become a powerful therapeutic tool. The potential of this ap...

Alcohols and aryl carboxylic acids are among the most commercially abundant, synthetically versatile, and operationally convenient building blocks in organic chemistry. Despite their widespread availa...

Luo and coworkes from Tsinghua University report a novel method for deracemisation in JACS

The total synthesis of aleutianamin was enabled by a new convergent coupling reaction.

With one confirmed case, public health officials are tracing contacts and hoping to ramp up testing

Calculations optimise the total synthesis of natural products by addressing challenges in the 1,5 HAT key reaction.

Heilonine is an alkaloid isolated in 1989 from Fritillaria ussuriensis and belongs to the structural...

Curated daily chemistry problems. Six attempts to solve the questions, on topics from named reactions to total synthesis.

The di-π-methane (DPM) rearrangement is an important organic photorearrangement that converts 1,4-diene-containing compounds to vinyl cyclopropanes, often resulting in extensive, synthetically valuabl...

l-(+)-Muscarine is one of the most toxic mushroom metabolites. We identified its congener 4’-phosphomuscarine in the fool's funnel and in various fiber cap mushrooms, and chemically and pharmacologic...

Pleurotin (1, see Fig. 1) is a benzoquinone meroterpenoid that was first isolated in the late 1940s....