Chad Brambley
@chadbrambley.bsky.social
Computational structural immunologist.
Postdoc | Baker lab | Notre Dame | 🧬💻
Father, husband, leftist. Opinions my own.
Postdoc | Baker lab | Notre Dame | 🧬💻
Father, husband, leftist. Opinions my own.
Reposted by Chad Brambley
Happy to have been part of this work with Karen Hastings and team at the Univ of Arizona quantifying the impact of structure on neoAg immunogenicity. Kudos to @chadbrambley.bsky.social and the others for their awesome work. Look for modeling to improve neoAg prediction!
jitc.bmj.com/content/13/1...
jitc.bmj.com/content/13/1...
Structural changes from wild-type define tumor-rejecting neoantigens
Background Challenges in predicting which neoantigens mediate tumor rejection limit the efficacy of neoantigen vaccines to treat cancers, especially for cancers with a high mutational burden like cuta...
jitc.bmj.com
October 24, 2025 at 8:08 PM
Happy to have been part of this work with Karen Hastings and team at the Univ of Arizona quantifying the impact of structure on neoAg immunogenicity. Kudos to @chadbrambley.bsky.social and the others for their awesome work. Look for modeling to improve neoAg prediction!
jitc.bmj.com/content/13/1...
jitc.bmj.com/content/13/1...
I had a blast presenting our work on T cell mimotope discovery! A huge thank you to @epivax.bsky.social for hosting such a great meeting and inviting us to speak. I don't want to leave Rhode Island!
Super postdoc @chadbrambley.bsky.social killing it at the AI/HI Immunoinformatics workshop, telling us about finding molecular mimics of antigenic epitopes. Thanks to @epivax.bsky.social for the invitation and opportunity!
June 7, 2025 at 1:28 AM
I had a blast presenting our work on T cell mimotope discovery! A huge thank you to @epivax.bsky.social for hosting such a great meeting and inviting us to speak. I don't want to leave Rhode Island!
It was a cold and snowy one, but today we stood up for science! The fight is just beginning though, don't let them dismantle OUR research.
March 7, 2025 at 8:57 PM
It was a cold and snowy one, but today we stood up for science! The fight is just beginning though, don't let them dismantle OUR research.
Ok, I've GOT to share this one. Genius might be a tad strong, but who am I to refute my boss haha
I am so excited. Small victories - find joy where you can. Preliminary data for the grant. @chadbrambley.bsky.social is a genius. Big errors because these are log scales, but still.
February 5, 2025 at 10:57 PM
Ok, I've GOT to share this one. Genius might be a tad strong, but who am I to refute my boss haha
Reposted by Chad Brambley
PDB viewer integration into Obsidian - I need this yesterday (source in alt text)
January 21, 2025 at 11:39 AM
PDB viewer integration into Obsidian - I need this yesterday (source in alt text)
Reposted by Chad Brambley
In a world of Kid Rocks and Carrie Underwoods, be a Woody Guthrie.
January 17, 2025 at 7:23 PM
In a world of Kid Rocks and Carrie Underwoods, be a Woody Guthrie.
Can NOT believe we pulled it off in regulation! #GoIrish #NotreDame
NOTRE DAME IS ONTO THE CFP TITLE GAME AFTER A GAME-WINNING FG 🍀
The Fighting Irish are back in the national championship game for the first time since 2013.
The Fighting Irish are back in the national championship game for the first time since 2013.
January 10, 2025 at 4:23 AM
Can NOT believe we pulled it off in regulation! #GoIrish #NotreDame
#immunosky Anyone else wake up to good news from grant Santa? This one's an F32 fellowship, to help take on TCR cross reactivity. Honored and excited to be working on this and grateful for the support!
December 28, 2024 at 1:13 AM
#immunosky Anyone else wake up to good news from grant Santa? This one's an F32 fellowship, to help take on TCR cross reactivity. Honored and excited to be working on this and grateful for the support!
Reposted by Chad Brambley
Student: I want to master #Linux, but I can’t grow a beard.
Master Foo: Once you master linux you become the beard.
Upon hearing this, the student was enlightened.
Master Foo: Once you master linux you become the beard.
Upon hearing this, the student was enlightened.
December 2, 2024 at 2:01 PM
Student: I want to master #Linux, but I can’t grow a beard.
Master Foo: Once you master linux you become the beard.
Upon hearing this, the student was enlightened.
Master Foo: Once you master linux you become the beard.
Upon hearing this, the student was enlightened.
Reposted by Chad Brambley
Design of high specificity binders for peptide-MHC-I complexes https://www.biorxiv.org/content/10.1101/2024.11.28.625793v1
Design of high specificity binders for peptide-MHC-I complexes https://www.biorxiv.org/content/10.1101/2024.11.28.625793v1
Class I MHC molecules present peptides derived from intracellular antigens on the cell surface for i
www.biorxiv.org
November 29, 2024 at 5:15 AM
Design of high specificity binders for peptide-MHC-I complexes https://www.biorxiv.org/content/10.1101/2024.11.28.625793v1
Reposted by Chad Brambley
Will save more time that asking ChatGPT!
This is pretty dope. Add pylustrator.start() at the top of a script and your plots are interactively scalable, composable, movable, etc with your mouse www.youtube.com/watch?v=xXPI... pylustrator.readthedocs.io/en/latest/ h/t @tommytang.bsky.social
pylustrator demonstration
YouTube video by Randrian42
www.youtube.com
November 28, 2024 at 12:35 AM
Will save more time that asking ChatGPT!
Reposted by Chad Brambley
🚀 Advancing T-cell receptor (TCR) research! We developed tcrBLOSUM, a specialized substitution matrix for sensitive alignment of distant epitope-specific TCRs. Find out how our findings expand TCR analysis: doi.org/10.1093/bib/... #Bioinformatics #Immunology #AIRR with @pmeysman.bsky.social
tcrBLOSUM: an amino acid substitution matrix for sensitive alignment of distant epitope-specific TCRs
Abstract. Deciphering the specificity of T-cell receptor (TCR) repertoires is crucial for monitoring adaptive immune responses and developing targeted immu
doi.org
November 26, 2024 at 6:50 PM
🚀 Advancing T-cell receptor (TCR) research! We developed tcrBLOSUM, a specialized substitution matrix for sensitive alignment of distant epitope-specific TCRs. Find out how our findings expand TCR analysis: doi.org/10.1093/bib/... #Bioinformatics #Immunology #AIRR with @pmeysman.bsky.social
I called both Wilson and Rutherford counties home during grad school. Not exactly surprised by my former neighbors, but I am both ashamed and embarrassed for them.
CHALKBEAT — After Wilson County removed 400 books from their school libraries after the new GOP law, other counties are using their list as a cheat sheet, including Montgomery and Rutherford, where Frances Rosales asked for 150 books to be removed. www.timesfreepress.com/news/2024/no...
November 24, 2024 at 6:01 PM
I called both Wilson and Rutherford counties home during grad school. Not exactly surprised by my former neighbors, but I am both ashamed and embarrassed for them.
I think this will do nicely for my inaugural skeet. Thanks boss for the shout out! Eagerly (and cautiously) excited to get this thing funded. We have work to do!
#immunosky
#immunosky
My postdoc Chad is happy today - kudos and congratulations!! More when (if?) the news becomes official. TCR cross-reactivity, you are on notice!
#immunosky
🧬🧶🤘🤘
#immunosky
🧬🧶🤘🤘
November 23, 2024 at 4:56 PM
I think this will do nicely for my inaugural skeet. Thanks boss for the shout out! Eagerly (and cautiously) excited to get this thing funded. We have work to do!
#immunosky
#immunosky