Center for Gene Expression (CGEN)
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cgen2025.bsky.social
Center for Gene Expression (CGEN)
@cgen2025.bsky.social
16 followers 3 following 7 posts
DNRF Center of Excellence performing ground-breaking research on the multiple aspects of gene expression, based at ICMM, UCPH. It is led by Jesper Svejstrup and also houses research groups led by Simon Bekker-Jensen, Lea Gregersen and Peter Haahr.
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Reposted by Center for Gene Expression (CGEN)
jsvejstrup.bsky.social
I’m very happy to share Zhong Han’s beautiful work on the biochemical function of Senataxin, encoded by a gene that is mutated in rare and early-disabling neurodegenerative diseases. Turns out it rescues backtracked RNA polymerase II during early transcription! www.sciencedirect.com/science/arti...
A role for human senataxin in contending with pausing and backtracking during transcript elongation
Senataxin (SETX) regulates RNA polymerase II (RNAPII) transcription and helps maintain genome stability, at least partly by suppressing R-loops. Howev…
www.sciencedirect.com
November 12, 2025 at 5:36 PM
cgen2025.bsky.social
Exciting Expansion at CGEN! We’re thrilled to welcome Fena Ochs and Niels Erik Møllegaard. 🔬 Fena brings cutting-edge expertise in 3D chromatin organization and its role in gene regulation, DNA repair, and cell division. 🧬Niels Erik’s expertise is in genome structure and DNA helix conformation
October 30, 2025 at 1:59 PM
Reposted by Center for Gene Expression (CGEN)
gregersenlab.bsky.social
Interested in measuring RNAPII elongation rates? We developed DRB/TTchem-seq2 to directly measure rates across 3,000+ genes 🧬
genome.cshlp.org/content/earl...
This fantastic work led by Haiyue Liu reveals gene and intra-genic variation, links to histone marks & elongation factors
Details below! 👇
Kinetic measurement of gene-specific RNA polymerase II transcription elongation rates
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
genome.cshlp.org
October 24, 2025 at 10:25 AM
cgen2025.bsky.social
New review in Genes and Development: genesdev.cshlp.org/content/earl... Blear & Svejstrup review a critical transcription QC checkpoint at the beginning of protein-coding genes, where the cell assesses RNA polymerase II quality and decides whether it will continue, or not. @jsvejstrup.bsky.social
genesdev.cshlp.org
September 23, 2025 at 12:15 PM
cgen2025.bsky.social
🌟 Check out the latest preprint from our center 🌟

This work brings us one step closer to gaining a deeper understanding of gene expression regulation - a core mission of our center 🧬 🧫

If you want to know more about CGEN visit our website: cgen.ku.dk

@dg.dk @ucph.bsky.social
September 19, 2025 at 12:32 PM
Reposted by Center for Gene Expression (CGEN)
jsvejstrup.bsky.social
Extremely proud to share the impressive work done by Anouk Olthof et al. on how cells maintain healthy levels of RNAPII, and how they respond when levels are too low. Fascinating stuff, we think www.biorxiv.org/content/10.1...
Systems-level feedback loops maintain gene expression homeostasis following RNA polymerase II dosage perturbation
Transcription is regulated by sequence-specific transcription factors and enzymes allowing access to genes in chromatin. However, recent data indicate that the abundance of RNA polymerase II (RNAPII) ...
www.biorxiv.org
September 19, 2025 at 10:55 AM
cgen2025.bsky.social
Four of our six Master's students successfully defended their theses last week. In the coming weeks, the remaining two will defend theirs, and Mads, our laboratory technician trainee, will also complete his training. Last Friday, we held a joint celebration at the center. Congratulations to all! ⭐
June 16, 2025 at 11:39 AM
cgen2025.bsky.social
Excited to share the latest paper from CGEN just published in Molecular Cell! This study demonstrates the specificity of RNAPII-CTD kinases CDK9 and CDK12, and also describes the activation mechanism of CDK12/13 in cells by the PAF1C subunit CDC73.

authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
May 2, 2025 at 11:59 AM
cgen2025.bsky.social
Another opportunity to join CGEN: we are seeking 2 or more Postdocs 🧬🧪

Deadline March 18, 2025

Please share with your relevant networks!

employment.ku.dk/faculty/?sho...
Postdoc in gene expression
employment.ku.dk
February 24, 2025 at 11:42 AM
cgen2025.bsky.social
💥 CGEN is hiring 💥
We are looking for 2 or more highly motivated PhD students to join our DNRF Center of Excellence, Center for Gene Expression (CGEN) at University of Copenhagen.

Deadline: March 6, 2025

Please share with your relevant networks!
employment.ku.dk/phd/?show=16...
PhD fellowships at the Center for Gene Expression
employment.ku.dk
February 24, 2025 at 11:31 AM