Cédric Gobet
@cedric-gobet.bsky.social
Scientific collaborator @EPFL 🧬 Studying circadian rhythms, fasting/feeding cycles & translation regulation | Chronobiology • Gene expression • Systems biology • Computational biology
Huge thanks to everyone involved! More to come soon!
April 10, 2025 at 6:40 AM
Huge thanks to everyone involved! More to come soon!
We combined RNA-seq, Ribo-seq, tRNA quantification, and proteomics to study BCAA starvation.
💥 Valine codon stalling creates elongation bottlenecks.
🧩 Codon identity, tRNA dynamics, and amino acid levels shape translation and protein output.
#RiboSeq #Translation #tRNA #MolecularBiology #BCAA
💥 Valine codon stalling creates elongation bottlenecks.
🧩 Codon identity, tRNA dynamics, and amino acid levels shape translation and protein output.
#RiboSeq #Translation #tRNA #MolecularBiology #BCAA
April 10, 2025 at 6:40 AM
We combined RNA-seq, Ribo-seq, tRNA quantification, and proteomics to study BCAA starvation.
💥 Valine codon stalling creates elongation bottlenecks.
🧩 Codon identity, tRNA dynamics, and amino acid levels shape translation and protein output.
#RiboSeq #Translation #tRNA #MolecularBiology #BCAA
💥 Valine codon stalling creates elongation bottlenecks.
🧩 Codon identity, tRNA dynamics, and amino acid levels shape translation and protein output.
#RiboSeq #Translation #tRNA #MolecularBiology #BCAA
🧬 Codon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 10, 2025 at 6:40 AM
🧬 Codon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Riboclette predicts ribosome density under 6 starvation conditions. Beyond strong performance, it brings interpretability—highlighting codon-specific and motif-level drivers of ribosome stalling during stress.
#DeepLearning #RibosomeProfiling #ComputationalBiology
#DeepLearning #RibosomeProfiling #ComputationalBiology
April 10, 2025 at 6:40 AM
Riboclette predicts ribosome density under 6 starvation conditions. Beyond strong performance, it brings interpretability—highlighting codon-specific and motif-level drivers of ribosome stalling during stress.
#DeepLearning #RibosomeProfiling #ComputationalBiology
#DeepLearning #RibosomeProfiling #ComputationalBiology
🧠 Riboclette: Conditional deep learning model reveals translation elongation determinants during amino acid deprivation
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Conditional Deep Learning Model Reveals Translation Elongation Determinants during Amino Acid Deprivation
Translation elongation plays a key role in cellular homeostasis, and dysregulation of this process has been implicated in various diseases and metabolic disorders. Uncovering the causes of intragenic ...
www.biorxiv.org
April 10, 2025 at 6:40 AM
🧠 Riboclette: Conditional deep learning model reveals translation elongation determinants during amino acid deprivation
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...