Christopher Snow
@cdsnow.bsky.social
Professor at Colorado State University. Previously MIT Chemistry (Tidor), Stanford Biophysics (Pande), Caltech Chemistry and Chemical Engineering (Arnold). Interests: Protein Engineering, Computational Protein Design, ML, Biomolecular Crystals
AlphaFold3 Cautionary Tale: We deposited multiple PDB entries for “CJ,” a binding protein that domain swaps when crystallizing. Local AF3 in the presence of decane gives the domain swapped form with high confidence extended N-terminus (4/5 models). Yikes! Perhaps template-driven false confidence...
November 25, 2024 at 8:01 PM
AlphaFold3 Cautionary Tale: We deposited multiple PDB entries for “CJ,” a binding protein that domain swaps when crystallizing. Local AF3 in the presence of decane gives the domain swapped form with high confidence extended N-terminus (4/5 models). Yikes! Perhaps template-driven false confidence...