UCSF Cell Design Institute
banner
cdi-ucsf.bsky.social
UCSF Cell Design Institute
@cdi-ucsf.bsky.social
Official Account of the Cell Design Institute @UCSF.
Bringing a unique foundational approach to cell therapies.
https://celldesigninstitute.org
Congratulations to all collaborators and thank you to our funders!
December 19, 2024 at 9:00 PM
Toshi and Coralie engineered synthetic organizer cells that programmably send signals to developing embryos in vitro. They observe highly ordered beating heart like structures, and show how organizer cells can direct sophisticated developmental assemblies!
www.youtube.com/watch?v=Jp0K...
Synthetic organizer cells guide development via spatial and biochemical instructions
YouTube video by UCSF Cell Design Institute
www.youtube.com
December 19, 2024 at 9:00 PM
Reposted by UCSF Cell Design Institute
For our inaugural @bsky.app post – 2 papers and the cover of Science @science.org!!

Dr. Nish Reddy et al. built T cells that suppress inflammation in specific tissues bit.ly/4fX8JxN

Dr. Milos Simic, Dr. Payal Watchmaker et al. built T cells that deliver therapies to the brain bit.ly/4g0I5Ej
December 13, 2024 at 3:41 PM
Huge congratulations to all authors and thank you to our funders and institutions, including @ucsfcancer.bsky.social @ucsfdc.bsky.social, NIH/NCI, NIH/NINDS, NIH/NIDDK, ARPA-H, Valhalla Foundation, and many others.
December 5, 2024 at 11:59 PM
Paper 2 led by Lim Lab postdoc Dr. Milos Simic @drmilossimic.bsky.social and Okada Lab postdoc Payal Watchmaker describes T cells engineered to deliver therapeutic payloads to the brain 🧠 - both for treating cancer and neuroinflammation such as in multiple sclerosis.

www.youtube.com/watch?v=u0c5...
Programming tissue-sensing T cells that deliver therapies to the brain
YouTube video by UCSF Cell Design Institute
www.youtube.com
December 5, 2024 at 11:59 PM
Paper 1 led by recent Lim Lab graduate Dr. Nish Reddy (@nishreddy.bsky.social, now a postdoc in Feng Zhang's lab @broadinstitute.org) involves T cells engineered to home into and suppress inflammation, including in organ transplant models.

www.youtube.com/watch?v=C3gA...
Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs
YouTube video by UCSF Cell Design Institute
www.youtube.com
December 5, 2024 at 11:59 PM