Catrin Lutz
@catrinlutz.bsky.social
Postdoc at the Netherlands Cancer Institute. Cancer Modeller. Rat Advocate.
8 years of xenografting breast cancer cell lines and thorough characterisation of the resulting mouse models revealed that context really matters. Breast cancer growth morphology and aggressivess are regulated by auto- and paracrine TGF-beta signalling and strongly depend on transplantation method.
Large-scale Characterization of Orthotopic Cell Line–Derived Xenografts Identifies TGFβ Signaling as a Key Regulator of Breast Cancer Morphology and Aggressiveness
Establishment and investigation of the largest collection of fully characterized breast cancer cell line xenograft models identifies key determinants of tumor morphology and aggressiveness and enables...
aacrjournals.org
July 17, 2025 at 11:17 AM
8 years of xenografting breast cancer cell lines and thorough characterisation of the resulting mouse models revealed that context really matters. Breast cancer growth morphology and aggressivess are regulated by auto- and paracrine TGF-beta signalling and strongly depend on transplantation method.
Immensely happy and grateful that our paper got featured in the latest highlights in cancer research. Big thanks to the EACR and all co-authors whose efforts went into this piece of work!
🚀 Discover the latest breakthroughs in cancer research!
The July 2025 Highlights in Cancer Research features 10 standout papers, including insights into lung cancer progression and chemo sensitivity linked to the oestrous cycle.
Read more: magazine.eacr.org/highlights-i...
The July 2025 Highlights in Cancer Research features 10 standout papers, including insights into lung cancer progression and chemo sensitivity linked to the oestrous cycle.
Read more: magazine.eacr.org/highlights-i...
July 17, 2025 at 11:04 AM
Immensely happy and grateful that our paper got featured in the latest highlights in cancer research. Big thanks to the EACR and all co-authors whose efforts went into this piece of work!
Reposted by Catrin Lutz
Proud! 💙 Our scientific director Thijn Brummelkamp receives the Spinoza Prize, a prize for scientists who belong to the best researchers worldwide. A wonderful recognition for his groundbreaking research.
Congrats Thijn! 🎉 @thijnbrummel.bsky.social
Full article ➡️ bit.ly/40p4KnK
Congrats Thijn! 🎉 @thijnbrummel.bsky.social
Full article ➡️ bit.ly/40p4KnK
June 27, 2025 at 5:51 AM
Proud! 💙 Our scientific director Thijn Brummelkamp receives the Spinoza Prize, a prize for scientists who belong to the best researchers worldwide. A wonderful recognition for his groundbreaking research.
Congrats Thijn! 🎉 @thijnbrummel.bsky.social
Full article ➡️ bit.ly/40p4KnK
Congrats Thijn! 🎉 @thijnbrummel.bsky.social
Full article ➡️ bit.ly/40p4KnK
Reposted by Catrin Lutz
📢 Are you approaching the epigenetic world? Or you want to know more about ATAC-seq and it's applications?
In this case join the @oncodeinstitute.bsky.social workshop that will take place the 19th of September at the @nkinl.bsky.social !!
Places are limited to 35!! Subscribe at the following link:
In this case join the @oncodeinstitute.bsky.social workshop that will take place the 19th of September at the @nkinl.bsky.social !!
Places are limited to 35!! Subscribe at the following link:
Masterclass: ATAC-seq data analysis and applications | Oncode Institute
By Sebastian Gregoricchio (lab Wilbert Zwart, Netherlands Cancer Institute)
oncodeinstitute.nl
May 7, 2025 at 9:03 AM
📢 Are you approaching the epigenetic world? Or you want to know more about ATAC-seq and it's applications?
In this case join the @oncodeinstitute.bsky.social workshop that will take place the 19th of September at the @nkinl.bsky.social !!
Places are limited to 35!! Subscribe at the following link:
In this case join the @oncodeinstitute.bsky.social workshop that will take place the 19th of September at the @nkinl.bsky.social !!
Places are limited to 35!! Subscribe at the following link:
It's been a real pleasure having this joint ICR NKI retreat again. Many thanks for coming over and the truly inspiring discussions!
We had the most fantastic joint lab retreat with our friends @josjonkers.bsky.social and Sabine Linn and their super smart colleagues @nkinl.bsky.social. The start of a lot of collaborative work targeting HRD and ILC.
April 5, 2025 at 10:15 AM
It's been a real pleasure having this joint ICR NKI retreat again. Many thanks for coming over and the truly inspiring discussions!
Reposted by Catrin Lutz
Excited to share our review on epigenetic reprogramming in brain metastasis. We review published studies on epigenetic drivers and outline future research directions we’re exploring: www.nature.com/articles/s41...
@breastcancernow.bsky.social @stefanprekovic.bsky.social @researchireland.bsky.social
@breastcancernow.bsky.social @stefanprekovic.bsky.social @researchireland.bsky.social
The epigenetic landscape of brain metastasis - Oncogene
Oncogene - The epigenetic landscape of brain metastasis
www.nature.com
February 27, 2025 at 4:37 PM
Excited to share our review on epigenetic reprogramming in brain metastasis. We review published studies on epigenetic drivers and outline future research directions we’re exploring: www.nature.com/articles/s41...
@breastcancernow.bsky.social @stefanprekovic.bsky.social @researchireland.bsky.social
@breastcancernow.bsky.social @stefanprekovic.bsky.social @researchireland.bsky.social
Looking forward to this read =)
Very happy to see our review out in @natrevmcb.bsky.social!
Here we discuss how stem cells exert forces to sculpt tissues in development and homeostasis, and how stem cell mechanics go awry upon malignant transformation. Read it here 👇
www.nature.com/articles/s41...
Here we discuss how stem cells exert forces to sculpt tissues in development and homeostasis, and how stem cell mechanics go awry upon malignant transformation. Read it here 👇
www.nature.com/articles/s41...
Shaping epithelial tissues by stem cell mechanics in development and cancer - Nature Reviews Molecular Cell Biology
Adult stem cells self-renew and differentiate to build, maintain and repair tissues. This Review discusses recent insights into the contribution of mechanical forces produced by epithelial stem cell a...
www.nature.com
January 29, 2025 at 5:31 PM
Looking forward to this read =)
If you're interested in luminal breast cancer and the advances made in the field, from molecular subtyping to metastatic disease and disease modelling, check out our review, now out in Endocrine-Related Cancer. Thanks @stefanprekovic.bsky.social, @damirvareslija.bsky.social and Hendrik Messal.
Sharing the final version of our review on the complex landscape of luminal breast cancer now published with @stefanprekovic.bsky.social, @catrinlutz.bsky.social, and Hendrik. Available here: doi.org/10.1530/ERC-...
January 11, 2025 at 7:55 PM
If you're interested in luminal breast cancer and the advances made in the field, from molecular subtyping to metastatic disease and disease modelling, check out our review, now out in Endocrine-Related Cancer. Thanks @stefanprekovic.bsky.social, @damirvareslija.bsky.social and Hendrik Messal.
Reposted by Catrin Lutz
📢 Applications for the NKI PhD program open from Jan 1 - Feb 28. Join our international research community in Amsterdam, working in cancer biology, AI research & life sciences with leading scientists and top facilities #PhD #CancerResearch More info: bit.ly/3O4bOjq
November 29, 2024 at 8:36 AM
📢 Applications for the NKI PhD program open from Jan 1 - Feb 28. Join our international research community in Amsterdam, working in cancer biology, AI research & life sciences with leading scientists and top facilities #PhD #CancerResearch More info: bit.ly/3O4bOjq
And lastly, hot off the press in Oncogene, a great effort by the Prekovic lab @stefanprekovic.bsky.social on describing the roles of STAG2 in cohesin biology and cancer:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Emerging roles of cohesin-STAG2 in cancer - Oncogene
Oncogene - Emerging roles of cohesin-STAG2 in cancer
www.nature.com
November 30, 2024 at 10:53 PM
And lastly, hot off the press in Oncogene, a great effort by the Prekovic lab @stefanprekovic.bsky.social on describing the roles of STAG2 in cohesin biology and cancer:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Here we describe models for hormone-dependent breast cancer with a thorough focus on rat models generated over the past 100+ years:
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Rat Models of Hormone Receptor-Positive Breast Cancer - Journal of Mammary Gland Biology and Neoplasia
Hormone receptor-positive (HR+) breast cancer (BC) is the most common type of breast cancer among women worldwide, accounting for 70–80% of all invasive cases. Patients with HR+ BC are commonly treate...
link.springer.com
November 30, 2024 at 10:42 PM
Here we describe models for hormone-dependent breast cancer with a thorough focus on rat models generated over the past 100+ years:
link.springer.com/article/10.1...
link.springer.com/article/10.1...
To start up here I'd like to share some of our recently published reviews:
November 30, 2024 at 10:36 PM
To start up here I'd like to share some of our recently published reviews: