Thanks!! 🙌🏽 No but HCP derivatives are on NDA and a more select set of cleaned data on OpenNeuro (what I used for FC) - I’ll talk to our group about sharing FC!

We rec. you cite the Sci. Data manuscript when using the TCP:

Chopra, S., Cocuzza, C.V., Lawhead, C. et al. The Transdiagnostic Connectome Project: an open dataset for studying brain-behavior relationships in psychiatry. Sci Data 12, 923 (2025). doi.org/10.1038/s415...

Happy sciencing all!! 🎉🧠⚛️

The TCP dataset is openly available on:

OpenNeuro: openneuro.org/datasets/ds0...
NDA: nda.nih.gov/study.html?i...

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...And validated the use of the TCP for discoverability of large-scale functional network properties and task activation effects 🧵8🧠

We did extensive QC analyses showing that motion was well-controlled by HCP processing... 🧵7🧠

MRI data includes high-resolution anatomicals, 4 rest fMRI, & 2 task fMRI (Stroop & Emotional Faces). We used HCP processing pipelines w/ ICA-FIX denoising & encourage the use of TCP for clinical network neuro research questions! 🧵6🧠

The TCP dataset has 50+ self-report & clinician-assisted behavioral, cognitive, and & clinical measures. We are enthusiastic about the use of TCP toward empirically-driven, dimensional, & hierarchically-informed phenotyping 🧵5🧠

The TCP dataset includes MRI, fMRI, & richly-sampled behavioral data from participants with and without psychiatric diagnoses, sampled transdiagnostically 🧵4🧠

And those of the team not (yet) on bsky! 🎉 Connor Lawhead, Poornima Kumar, Arielle Rubenstein, Julia Moses, Lia Chen, Crystal Blankenbaker, Bryce Gillis, & Justin Baker 🧵3🧠

HUGE congrats and thank you to the team & collaborators!! 🎉@sidchop.bsky.social @jocelynricard.bsky.social @loiclabache.bsky.social labache.bsky.social @neurlo.bsky.social @lauragermine.bsky.social @harpaz-rotem.bsky.social @bttyeo.bsky.social @avramholmes.bsky.social @holmeslab-bhi.bsky.social 🧵2🧠

I’m so pleased to share and discuss this work with our community! A massive thank you to coauthors who supported and guided me in this project!! @avramholmes.bsky.social @sidchop.bsky.social @ashleasegal.bsky.social @loiclabache.bsky.social @rowenaechin.bsky.social & Kaley Joss 🧵9/9🧠

🚨Conclusions🚨 Brain network dynamics link w/ dimensions of functioning across health & psychiatric disease & flatten w/ cognitive demand in patients, suggesting failure to recruit processing resources. Prominence of cognitive control suggests executive dysfunction cuts across psychopathology 8/9

Further emphasizing the importance of cognitive control processing to transdiagnostic symptomatology: rest-to-Stroop-task shifts in connectivity discriminated symptom fingerprints better than all other models 🧵7/9🧠

3. Network dynamics discriminated symptom fingerprints w/ high accuracy; more robustly than the presence of disease or primary diagnosis. Simulating lesions to each functional system: this link was established by info. processing along frontoparietal, somato/motor, visual, & thalamic networks 🧵6/9🧠

2. Whole-brain functional connectomes from resting- & task-state fMRI were decomposed to reveal dynamic constraints on across-state shifts in connectivity. Relative to healthy participants, patients had *flattened* dynamics, suggesting “de-differentiated” network structure in psychopathology 🧵5/9🧠

1. We used hierarchical methods on 110 behavioral, cognitive, & clinical measures & profiled 4 core dimensions of functioning: internalizing, externalizing, cognitive, & social/reward. We then developed *symptom fingerprints* – individualized expression patterns across these 4 dimensions 🧵4/9🧠

Using the 11 diagnoses in the Transdiagnostic Connectome Project we tackled 3 Qs: 1. What dimensions of functioning pattern psychiatric symptoms? 2. How are dynamics impaired in patients? 3. Do dynamics classify symptom dimensions > diagnoses? 3/9

in-press Sci. Data: www.medrxiv.org/content/10.1...

Brain network dynamics – the nonstationary flow of information across brain systems – map individual diffs. in cognition/behavior better than activity or temporally-fixed connectivity alone. This has been shown in depression and schizophrenia; we asked if this extends transdiagnostically… 🧵2/9🧠