...And validated the use of the TCP for discoverability of large-scale functional network properties and task activation effects 🧵8🧠

We did extensive QC analyses showing that motion was well-controlled by HCP processing... 🧵7🧠

MRI data includes high-resolution anatomicals, 4 rest fMRI, & 2 task fMRI (Stroop & Emotional Faces). We used HCP processing pipelines w/ ICA-FIX denoising & encourage the use of TCP for clinical network neuro research questions! 🧵6🧠

The TCP dataset has 50+ self-report & clinician-assisted behavioral, cognitive, and & clinical measures. We are enthusiastic about the use of TCP toward empirically-driven, dimensional, & hierarchically-informed phenotyping 🧵5🧠

The TCP dataset includes MRI, fMRI, & richly-sampled behavioral data from participants with and without psychiatric diagnoses, sampled transdiagnostically 🧵4🧠

Further emphasizing the importance of cognitive control processing to transdiagnostic symptomatology: rest-to-Stroop-task shifts in connectivity discriminated symptom fingerprints better than all other models 🧵7/9🧠

3. Network dynamics discriminated symptom fingerprints w/ high accuracy; more robustly than the presence of disease or primary diagnosis. Simulating lesions to each functional system: this link was established by info. processing along frontoparietal, somato/motor, visual, & thalamic networks 🧵6/9🧠

2. Whole-brain functional connectomes from resting- & task-state fMRI were decomposed to reveal dynamic constraints on across-state shifts in connectivity. Relative to healthy participants, patients had *flattened* dynamics, suggesting “de-differentiated” network structure in psychopathology 🧵5/9🧠

1. We used hierarchical methods on 110 behavioral, cognitive, & clinical measures & profiled 4 core dimensions of functioning: internalizing, externalizing, cognitive, & social/reward. We then developed *symptom fingerprints* – individualized expression patterns across these 4 dimensions 🧵4/9🧠

Using the 11 diagnoses in the Transdiagnostic Connectome Project we tackled 3 Qs: 1. What dimensions of functioning pattern psychiatric symptoms? 2. How are dynamics impaired in patients? 3. Do dynamics classify symptom dimensions > diagnoses? 3/9

in-press Sci. Data: www.medrxiv.org/content/10.1...

Brain network dynamics – the nonstationary flow of information across brain systems – map individual diffs. in cognition/behavior better than activity or temporally-fixed connectivity alone. This has been shown in depression and schizophrenia; we asked if this extends transdiagnostically… 🧵2/9🧠

🚨Preprint!🚨 So excited to share my 1st major study as a postdoc at @holmeslab-bhi.bsky.social!🤘

www.biorxiv.org/content/10.1...

Using a transdiagnostic framework, we found that brain network dynamics were able to discriminate individualized psychiatric symptom profiles with high accuracy 🧵1/9👇