Dr. Carl
@carlwc.bsky.social
Biomanufacturing by day, microgravity life science advisor by night. Sometimes, the streams cross.
Nice review of micro-g protein crystal experiments. Is the average improvement of 0.3 Å significant and worth the cost/time?
www.mdpi.com/2073-4352/14...
www.mdpi.com/2073-4352/14...
www.mdpi.com
August 7, 2025 at 8:03 PM
Nice review of micro-g protein crystal experiments. Is the average improvement of 0.3 Å significant and worth the cost/time?
www.mdpi.com/2073-4352/14...
www.mdpi.com/2073-4352/14...
I have started referring to the poly A tail as "the Fonzarelli sequence."
May 20, 2025 at 8:34 PM
I have started referring to the poly A tail as "the Fonzarelli sequence."
One of my favorite astronauts. Hope he gets to fly yet again
Don Pettit wants to go back to space again. And you know what, he should.
arstechnica.com/space/2025/0...
arstechnica.com/space/2025/0...
What’s it like to be 70 years old in space? “All those little aches and pains heal up.”
“When the flight docs say I’m ready to go back, I’m ready to do it.”…
arstechnica.com
April 28, 2025 at 10:36 PM
One of my favorite astronauts. Hope he gets to fly yet again
Reposted by Dr. Carl
Take a look at our March issue! tinyurl.com/3m893ddu
The cover shows a structure of a DNA/RNA heteroduplex crystallized in a microgravity environment in space. How does it compare with that obtained on Earth? Find out at tinyurl.com/uxdncu9v
The cover shows a structure of a DNA/RNA heteroduplex crystallized in a microgravity environment in space. How does it compare with that obtained on Earth? Find out at tinyurl.com/uxdncu9v
February 27, 2025 at 2:55 PM
Take a look at our March issue! tinyurl.com/3m893ddu
The cover shows a structure of a DNA/RNA heteroduplex crystallized in a microgravity environment in space. How does it compare with that obtained on Earth? Find out at tinyurl.com/uxdncu9v
The cover shows a structure of a DNA/RNA heteroduplex crystallized in a microgravity environment in space. How does it compare with that obtained on Earth? Find out at tinyurl.com/uxdncu9v
Always cool to see a molecule I've worked with on the PDB MoM. Purified H5 and other HAs for a flu vaccine
February's Molecule of the Month:
Sugar-binding protein on the surface of the H5N1 avian influenza virus
pdb101.rcsb.org/motm...
Sugar-binding protein on the surface of the H5N1 avian influenza virus
pdb101.rcsb.org/motm...
PDB101: Molecule of the Month: H5 Hemagglutinin
Sugar-binding protein on the surface of the H5N1 avian influenza virus
pdb101.rcsb.org
February 4, 2025 at 3:56 PM
Always cool to see a molecule I've worked with on the PDB MoM. Purified H5 and other HAs for a flu vaccine
Reposted by Dr. Carl
Alright fine I’ll do it myself - here’s a starter pack with a specific focus on space medicine / biology 🧑🚀
Albeit small right now (not sure who migrated over from the old place) so let me know if you’d like to be added!
go.bsky.app/4KVwKoJ
Albeit small right now (not sure who migrated over from the old place) so let me know if you’d like to be added!
go.bsky.app/4KVwKoJ
January 4, 2025 at 10:05 PM
Alright fine I’ll do it myself - here’s a starter pack with a specific focus on space medicine / biology 🧑🚀
Albeit small right now (not sure who migrated over from the old place) so let me know if you’d like to be added!
go.bsky.app/4KVwKoJ
Albeit small right now (not sure who migrated over from the old place) so let me know if you’d like to be added!
go.bsky.app/4KVwKoJ
I cringe every time I see AF mentioned as "solving all of protein folding." It's great, but far from perfect
Now that AlphaFold has tackled biology’s greatest challenge, scientists can turn to even bigger questions
magazine.hms.harvard...
magazine.hms.harvard...
Did AI Solve the Protein-Folding Problem? | Harvard Medicine Magazine
Now that AlphaFold has tackled biology’s greatest challenge, scientists can turn to even bigger questions
magazine.hms.harvard.edu
December 30, 2024 at 7:07 PM
I cringe every time I see AF mentioned as "solving all of protein folding." It's great, but far from perfect
Merry Christmas!
Is it really Christmas if you're not floating above your food tin Christmas space tree?
Is it really Christmas if you're not floating above your food tin Christmas space tree?
December 25, 2024 at 2:04 PM
Merry Christmas!
Is it really Christmas if you're not floating above your food tin Christmas space tree?
Is it really Christmas if you're not floating above your food tin Christmas space tree?
The duality of humans:
Friend: "Hey Carl, what would you like for Christmas?"
Carl: "I'd love to have a copy of this book."
Friend: "Hey Carl, what would you like for Christmas?"
Carl: "I'd love to have a copy of this book."
December 23, 2024 at 2:13 PM
The duality of humans:
Friend: "Hey Carl, what would you like for Christmas?"
Carl: "I'd love to have a copy of this book."
Friend: "Hey Carl, what would you like for Christmas?"
Carl: "I'd love to have a copy of this book."
Reposted by Dr. Carl
🧪 The mRNA Revolution Evolves: From personalized medicine to novel nanooparticle tech, the mRNA field is thriving. This PharmTech article looks at how industry leaders are overcoming manufacturing hurdles and pioneering new therapeutic approaches.
Exploring Opportunities for LNP Delivery in mRNA
LNPs have gained solid ground as a drug delivery system for mRNA due to their success in the vaccines arena.
www.pharmtech.com
December 9, 2024 at 1:48 AM
🧪 The mRNA Revolution Evolves: From personalized medicine to novel nanooparticle tech, the mRNA field is thriving. This PharmTech article looks at how industry leaders are overcoming manufacturing hurdles and pioneering new therapeutic approaches.
The curbus gardium flowers are sprouting! Winter is here!
December 6, 2024 at 3:00 PM
The curbus gardium flowers are sprouting! Winter is here!
"...calling for proposals that are bold in their vision and approach, offering clear pathways to achieving the $10 per gram target."
#mAbs
#mAbs
Exceptional Low-cost Monoclonal Antibody Manufacturing
Innovations for Exceptionally Low-cost Monoclonal Antibody (mAb) Manufacturing RFP
gcgh.grandchallenges.org
November 27, 2024 at 3:38 PM
"...calling for proposals that are bold in their vision and approach, offering clear pathways to achieving the $10 per gram target."
#mAbs
#mAbs
So cool! Just needs some googly eyes. 👀
I sometimes forget how flexible proteins are. It becomes really apparent when you use NMR states for an animation. That poor cofactor is getting pushed around a lot 😅
#sciart #blender3d #biocatalysis
#sciart #blender3d #biocatalysis
November 25, 2024 at 7:45 PM
So cool! Just needs some googly eyes. 👀