Carl Öberg MD PhD
@carloberg.bsky.social
Associate Professor | PI Dialysis & Renal Physiology Group | Lund University Sweden 🇸🇪
Additional studies with indinavir (GLUT4-blocker) had no effect on FDG diffusion, leading us to conclude that the observed effects were likely the result of GLUT1-inhibition.
![Forest plot showing 95% confidence intervals for UF rate, free water transport, diffusion capacity (MTAC) for 18F-deoxyglucose ([18-F]-DG), and MTACs for glucose, creatinine, urea and potassium.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:mlm2rmhobpzknkridc7qmz2b/bafkreib6v2su3adcdcudd47bwrabz6rr74zygxzx7ne6rpiztldwhirg5u@jpeg)
February 3, 2025 at 10:58 AM
Additional studies with indinavir (GLUT4-blocker) had no effect on FDG diffusion, leading us to conclude that the observed effects were likely the result of GLUT1-inhibition.
In our study, we not only found that phloretin reduced FDG transfer, supporting our hypothesis of transcellular transfer, but also a significant reduction using GLUT1:GLUT4-blocker ritonavir.
February 3, 2025 at 10:58 AM
In our study, we not only found that phloretin reduced FDG transfer, supporting our hypothesis of transcellular transfer, but also a significant reduction using GLUT1:GLUT4-blocker ritonavir.
We hypothesized that the observed reduction in glucose absorption due to pan-GLUT-blocker phloretin was either due to a reduction in 1. trans-cellular glucose transfer and little trapping 2. cellular absorption and trapping in peritoneal cells, 3. para-cellular glucose transfer.
February 3, 2025 at 10:58 AM
We hypothesized that the observed reduction in glucose absorption due to pan-GLUT-blocker phloretin was either due to a reduction in 1. trans-cellular glucose transfer and little trapping 2. cellular absorption and trapping in peritoneal cells, 3. para-cellular glucose transfer.
Here, we tracked the journey of glucose across the peritoneal membrane studying both conventional glucose and radiolabeled glucose (18-F-deoxyglucose) in the opposite direction (plasma→dialysate). Diffusive transport capacities for glucose were similar regardless of the direction of transport.
February 3, 2025 at 10:58 AM
Here, we tracked the journey of glucose across the peritoneal membrane studying both conventional glucose and radiolabeled glucose (18-F-deoxyglucose) in the opposite direction (plasma→dialysate). Diffusive transport capacities for glucose were similar regardless of the direction of transport.