Carl D. Modes
@carldmodes.bsky.social
Physics, biology, geometry, topology in complex biological networks, tissue mechanics, and morphogenesis. MPI-CBG and CSBD.
Reposted by Carl D. Modes
🤩👍🏼💪🏼 Meet #TopoSPAM - a high-performance simulation platform for biological morphogenesis with a friendly Python interface. @tudresden.bsky.social @csbdresden.bsky.social @mpi-cbg.de. Solve both continuous and discrete active mechanics! Released today: arxiv.org/abs/2509.24905
TopoSPAM: Topology grounded Simulation Platform for morphogenesis and biological Active Matter
We present a topology grounded, multiscale simulation platform for morphogenesis and biological active matter. Morphogenesis and biological active matter represent keystone problems in biology with ad...
arxiv.org
October 1, 2025 at 10:21 AM
🤩👍🏼💪🏼 Meet #TopoSPAM - a high-performance simulation platform for biological morphogenesis with a friendly Python interface. @tudresden.bsky.social @csbdresden.bsky.social @mpi-cbg.de. Solve both continuous and discrete active mechanics! Released today: arxiv.org/abs/2509.24905
Reposted by Carl D. Modes
So happy to see the cephalic furrow combo out back-to-back! This was a wonderful collaborative endeavor 🥹
We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)
September 4, 2025 at 1:17 PM
So happy to see the cephalic furrow combo out back-to-back! This was a wonderful collaborative endeavor 🥹
Reposted by Carl D. Modes
The moral of the story is that building the #bridge between #evolution & #morphogenesis is hard. I still think it needs a concerted push, because, to paraphrase the classic: "Everything in biology, even the #CF, starts making sense in the light of evolution." I add, it is #stuff_that_matters (12/12)
September 4, 2025 at 8:22 AM
The moral of the story is that building the #bridge between #evolution & #morphogenesis is hard. I still think it needs a concerted push, because, to paraphrase the classic: "Everything in biology, even the #CF, starts making sense in the light of evolution." I add, it is #stuff_that_matters (12/12)
Reposted by Carl D. Modes
We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)
September 4, 2025 at 8:22 AM
We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)
Reposted by Carl D. Modes
Dresden researchers @paveltomancak.bsky.social @bruvellu.bsky.social, Carl Modes, @cuencam15.bsky.social & colleagues published in @nature.com that a tissue fold in fruit fly embryos buffers mechanical stresses & may have evolved in response to mechanical forces. www.mpi-cbg.de/news-outreac...
Mechanical forces drive evolutionary change
A small tissue fold present in fruit fly embryos buffers mechanical stresses and may have evolved in response to mechanical forces.
www.mpi-cbg.de
September 3, 2025 at 3:26 PM
Dresden researchers @paveltomancak.bsky.social @bruvellu.bsky.social, Carl Modes, @cuencam15.bsky.social & colleagues published in @nature.com that a tissue fold in fruit fly embryos buffers mechanical stresses & may have evolved in response to mechanical forces. www.mpi-cbg.de/news-outreac...
Reposted by Carl D. Modes
Fantastic interaction with @carldmodes.bsky.social
and @liormoneta.bsky.social , who did all the modelling. It was great to work in such an interchangeable setting between biology and physics, to lear about #ShapeProgramming and shed a little more light on how organs gain their 3D shape.
and @liormoneta.bsky.social , who did all the modelling. It was great to work in such an interchangeable setting between biology and physics, to lear about #ShapeProgramming and shed a little more light on how organs gain their 3D shape.
September 1, 2025 at 9:22 PM
Fantastic interaction with @carldmodes.bsky.social
and @liormoneta.bsky.social , who did all the modelling. It was great to work in such an interchangeable setting between biology and physics, to lear about #ShapeProgramming and shed a little more light on how organs gain their 3D shape.
and @liormoneta.bsky.social , who did all the modelling. It was great to work in such an interchangeable setting between biology and physics, to lear about #ShapeProgramming and shed a little more light on how organs gain their 3D shape.
Reposted by Carl D. Modes
I am thrilled to share the main result of our work at @nordenlab.bsky.social with @liormoneta.bsky.social and @carldmodes.bsky.social . We bridged DevBiology + theoretical physics to understand how the eye becomes round #morphogenesis #devbio #biophysics #zebrafish www.biorxiv.org/content/10.1...
The Optic cup is actively shape programmed by independently patterned apical forces
During morphogenesis, initially flat tissues often must transition into complex 3D shapes, reminiscent of shape-programmable systems in physics and engineering. One key question in developmental biolo...
www.biorxiv.org
September 1, 2025 at 9:22 PM
I am thrilled to share the main result of our work at @nordenlab.bsky.social with @liormoneta.bsky.social and @carldmodes.bsky.social . We bridged DevBiology + theoretical physics to understand how the eye becomes round #morphogenesis #devbio #biophysics #zebrafish www.biorxiv.org/content/10.1...