Campàs Lab
@campaslab.bsky.social
Physics of Embryonic Self-Organization and Morphogenesis. Tweets by Otger Campàs (Professor, Chair of Tissue Dynamics and Director
at the Physics of Life Excellence Cluster of TU Dresden)
at the Physics of Life Excellence Cluster of TU Dresden)
Merci Bertrand! We see it on the surface of the tailbud and PSM. It goes doen in the somites, likely because of inverse polarity…
October 29, 2025 at 11:10 AM
Merci Bertrand! We see it on the surface of the tailbud and PSM. It goes doen in the somites, likely because of inverse polarity…
Thanks André! Marc worked relentlessly… indeed a lot of work
October 28, 2025 at 7:47 PM
Thanks André! Marc worked relentlessly… indeed a lot of work
You look very young 😂
October 28, 2025 at 2:48 PM
You look very young 😂
Btw, this is precisely the reason to use gastruloids. We first did the mouse gastruloids, then compared to in vivo in mouse, then human gastruloids. I think that in human it is as close as possible to we can get today...
October 28, 2025 at 2:39 PM
Btw, this is precisely the reason to use gastruloids. We first did the mouse gastruloids, then compared to in vivo in mouse, then human gastruloids. I think that in human it is as close as possible to we can get today...
In human it is nearly impossible because of obvious reasons…
October 28, 2025 at 1:55 PM
In human it is nearly impossible because of obvious reasons…
Impossible is nothing 😉 It is just very very difficult at the moment
October 28, 2025 at 1:50 PM
Impossible is nothing 😉 It is just very very difficult at the moment
Muchas gracias, Elias!
October 28, 2025 at 10:33 AM
Muchas gracias, Elias!
I want to finish by thanking Jesse @jesseveenvliet.bsky.social, his lab and my lab and Heidi and @ellensletten.bsky.social, for the outstanding and fun collaboration! It has been a blast! 😃 This is to many more to come 🍾🥂
October 28, 2025 at 8:25 AM
I want to finish by thanking Jesse @jesseveenvliet.bsky.social, his lab and my lab and Heidi and @ellensletten.bsky.social, for the outstanding and fun collaboration! It has been a blast! 😃 This is to many more to come 🍾🥂
Altogether, our data points to a shared physical mechanism of posterior body axis elongation unique to mammals, different from other vertebrate species!
October 28, 2025 at 8:25 AM
Altogether, our data points to a shared physical mechanism of posterior body axis elongation unique to mammals, different from other vertebrate species!
Is this mechanism happening in vivo? We checked whether the key features of this physical mechanism of elongation, uniform cell proliferation and a posterior actin cap, are present in mouse embryos. And it seems they do!
October 28, 2025 at 8:25 AM
Is this mechanism happening in vivo? We checked whether the key features of this physical mechanism of elongation, uniform cell proliferation and a posterior actin cap, are present in mouse embryos. And it seems they do!
In a nutshell, the tissue expansion caused by cell proliferation is mechanically constrained by a supracellular actin cap that redirects the forces and guides axis elongation!
October 28, 2025 at 8:25 AM
In a nutshell, the tissue expansion caused by cell proliferation is mechanically constrained by a supracellular actin cap that redirects the forces and guides axis elongation!
We used laser ablation to check if the bulk tissue underneath would expand when we ablate the surface actin… and it does in the posterior region where there is an actin cap! But not in the anterior side
October 28, 2025 at 8:25 AM
We used laser ablation to check if the bulk tissue underneath would expand when we ablate the surface actin… and it does in the posterior region where there is an actin cap! But not in the anterior side
We found a supracellular actin accumulation at the tissue surface only on the posterior half of the gastruloid - a posterior actin cap. But, does this cap mechanically constrain expansion?
October 28, 2025 at 8:25 AM
We found a supracellular actin accumulation at the tissue surface only on the posterior half of the gastruloid - a posterior actin cap. But, does this cap mechanically constrain expansion?
So, what prevents the gastruloid from inflating like a balloon? There is also the possibility that something mechanically constrains the lateral expansion of the tissue, forcing it to elongate along the AP axis
October 28, 2025 at 8:25 AM
So, what prevents the gastruloid from inflating like a balloon? There is also the possibility that something mechanically constrains the lateral expansion of the tissue, forcing it to elongate along the AP axis
… cell divisions are oriented along the anteroposterior axis. But they are not…
October 28, 2025 at 8:25 AM
… cell divisions are oriented along the anteroposterior axis. But they are not…
So, uniform cell proliferation drives elongation in both mouse and human gastruloids! But how is this possible? Proliferation causes isotropic pressure, so the gastruloid should grow like a sphere, unless…
October 28, 2025 at 8:25 AM
So, uniform cell proliferation drives elongation in both mouse and human gastruloids! But how is this possible? Proliferation causes isotropic pressure, so the gastruloid should grow like a sphere, unless…
What about human gastruloids? You guessed it… exactly the same!
October 28, 2025 at 8:25 AM
What about human gastruloids? You guessed it… exactly the same!