Fernando Calvo
@calvolab.bsky.social
Tumor Microenvironment Team at IBBTEC, Spain. Led by Fernando Calvo. Research interests in tumor-stroma communication and cancer-associated fibroblasts #CAFs #TME.
Se realizará en el @ibbtec.bsky.social en Santander (España), con dentro del programa de doctorado de #University of Cantabria y con la infraestructura del @csic.es. Estamos financiados por @erc.europa.eu, @contracancerinv.bsky.social, @ageinves.bsky.social. Se agradece difusión.
August 1, 2025 at 1:08 PM
Se realizará en el @ibbtec.bsky.social en Santander (España), con dentro del programa de doctorado de #University of Cantabria y con la infraestructura del @csic.es. Estamos financiados por @erc.europa.eu, @contracancerinv.bsky.social, @ageinves.bsky.social. Se agradece difusión.
We are based @ibbtec.bsky.social in Santander, Spain. We are part of #University of Cantabria and @csic.es. We are funded through @erc.europa.eu @contracancerinv.bsky.social and @ageinves.bsky.social. We will support the scientific+professional development of the researcher that fills the position.
May 23, 2025 at 1:17 PM
We are based @ibbtec.bsky.social in Santander, Spain. We are part of #University of Cantabria and @csic.es. We are funded through @erc.europa.eu @contracancerinv.bsky.social and @ageinves.bsky.social. We will support the scientific+professional development of the researcher that fills the position.
We have developed a model to investigate this process in detail and generated intriguing and exciting data that we aim to exploit in coming months. We have additional resources (clinical data, bioinformatics, molecular characterization) snd collaborations in place.
May 23, 2025 at 1:17 PM
We have developed a model to investigate this process in detail and generated intriguing and exciting data that we aim to exploit in coming months. We have additional resources (clinical data, bioinformatics, molecular characterization) snd collaborations in place.
This is an exciting project at the interphase of cancer biology and bioengineering, employing organ-on-chip approaches to describe how CAFs influence abnormal vascularization and drug perfusion in cancer.
May 23, 2025 at 1:17 PM
This is an exciting project at the interphase of cancer biology and bioengineering, employing organ-on-chip approaches to describe how CAFs influence abnormal vascularization and drug perfusion in cancer.
Thanks to all the authors, funding agencies (@contracancerinv.bsky.social, @erc.europa.eu, #AEI), and institutions (@univcantabria.bsky.social, @csic.es) that support our work.
11/11
END!
11/11
END!
April 25, 2025 at 2:09 PM
Thanks to all the authors, funding agencies (@contracancerinv.bsky.social, @erc.europa.eu, #AEI), and institutions (@univcantabria.bsky.social, @csic.es) that support our work.
11/11
END!
11/11
END!
Additionally, our findings establish a mechanistic link between proteostasis and mechanotransduction via the HSP90α-YAP axis and its impact in cancer development, with potential relevance in other contexts where YAP activity is implicated.
10/11
10/11
April 25, 2025 at 2:09 PM
Additionally, our findings establish a mechanistic link between proteostasis and mechanotransduction via the HSP90α-YAP axis and its impact in cancer development, with potential relevance in other contexts where YAP activity is implicated.
10/11
10/11
Notably, this regulation is particularly relevant in mechanically stressed environments like CAFs, where mechanotransduction dominates over Hippo-dependent control.
8/11
8/11
April 25, 2025 at 2:09 PM
Notably, this regulation is particularly relevant in mechanically stressed environments like CAFs, where mechanotransduction dominates over Hippo-dependent control.
8/11
8/11
While previous studies linked HSP90 to heat-shock-induced YAP activation via the Hippo pathway (Luo, Nat Cell Biol 2020), our findings describe a distinct mechanism that operates under normal temperature conditions, emphasizing a direct interaction between HSP90α and YAP.
7/11
7/11
April 25, 2025 at 2:09 PM
While previous studies linked HSP90 to heat-shock-induced YAP activation via the Hippo pathway (Luo, Nat Cell Biol 2020), our findings describe a distinct mechanism that operates under normal temperature conditions, emphasizing a direct interaction between HSP90α and YAP.
7/11
7/11
This mechanism was validated in non-tumoral contexts employing emergent vasculogenesis models in microfluidic devices, underscoring the broader relevance of the HSP90α-YAP axis beyond CAFs.
6/11
6/11
April 25, 2025 at 2:09 PM
This mechanism was validated in non-tumoral contexts employing emergent vasculogenesis models in microfluidic devices, underscoring the broader relevance of the HSP90α-YAP axis beyond CAFs.
6/11
6/11
We identify the mechanotransducer YAP as a key effector of HSP90α. YAP is activated in CAFs through mechanotransduction, playing a critical role in CAF function. e show that HSP90α depletion compromises YAP stability, and that YAP is the main mediator of HSP90α functions in CAFs.
5/11
5/11
April 25, 2025 at 2:09 PM
We identify the mechanotransducer YAP as a key effector of HSP90α. YAP is activated in CAFs through mechanotransduction, playing a critical role in CAF function. e show that HSP90α depletion compromises YAP stability, and that YAP is the main mediator of HSP90α functions in CAFs.
5/11
5/11
Our findings reveal a crucial role for the master chaperone HSP90α in shaping CAF functionality, influencing extracellular matrix (ECM) remodelling, tumour growth, and dissemination in experimental breast cancer models.
4/11
4/11
April 25, 2025 at 2:09 PM
Our findings reveal a crucial role for the master chaperone HSP90α in shaping CAF functionality, influencing extracellular matrix (ECM) remodelling, tumour growth, and dissemination in experimental breast cancer models.
4/11
4/11
This is exciting because the pro-tumorigenic function of HSP90 and proteostasis mechanisms has not been considered outside the cell autonomous context of cancer cells.
3/11
3/11
April 25, 2025 at 2:09 PM
This is exciting because the pro-tumorigenic function of HSP90 and proteostasis mechanisms has not been considered outside the cell autonomous context of cancer cells.
3/11
3/11
Through comprehensive gene expression analyses of human cancer stroma + unbiased chemical genomics approaches, we show that HSP90-dependent transcriptional programs are a consistent feature of CAFs associated with aggressive #TME and poor patient prognosis.
2/11
2/11
April 25, 2025 at 2:09 PM
Through comprehensive gene expression analyses of human cancer stroma + unbiased chemical genomics approaches, we show that HSP90-dependent transcriptional programs are a consistent feature of CAFs associated with aggressive #TME and poor patient prognosis.
2/11
2/11
Thanks also to funding agencies and institutions (@contracancerinv.bsky.social, #AEi, @erc.europa.eu, #IBBTEC, @csic.es c.es, @univcantabria.bsky.social) for supporting our work, and to all cancer patients that inspire our research (6/6)
Bluesky
ivcantabria.bsky.social
March 25, 2025 at 8:35 AM
Thanks also to funding agencies and institutions (@contracancerinv.bsky.social, #AEi, @erc.europa.eu, #IBBTEC, @csic.es c.es, @univcantabria.bsky.social) for supporting our work, and to all cancer patients that inspire our research (6/6)
Bea’s project was a tough one, taking many different routes that didn’t pan out. Bea’s hard work, enthusiasm, ideas and technical ability make it work. So proud of how she carried out the project and defended it today. Cheers to her! (5/6)
March 25, 2025 at 8:35 AM
Bea’s project was a tough one, taking many different routes that didn’t pan out. Bea’s hard work, enthusiasm, ideas and technical ability make it work. So proud of how she carried out the project and defended it today. Cheers to her! (5/6)
Interesting results linking stress and metabolic rearrangements in CAFs that we are currently preparing for publication. Stay tuned (4/6)
March 25, 2025 at 8:35 AM
Interesting results linking stress and metabolic rearrangements in CAFs that we are currently preparing for publication. Stay tuned (4/6)
This project is a continuation of our previous study (www.nature.com/articles/s41...), where Bea investigated the processes that influence HSF1 activity in CAFs, and new mechanisms of action supporting its pro-tumour role (3/6)
Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts - Nature Communications
It is unclear how specific signalling pathways are coordinated to generate pathologically activated cancer associated fibroblasts (CAFs). Here, Ferrari et al show that stromal expression of Dickkopf-3...
www.nature.com
March 25, 2025 at 8:35 AM
This project is a continuation of our previous study (www.nature.com/articles/s41...), where Bea investigated the processes that influence HSF1 activity in CAFs, and new mechanisms of action supporting its pro-tumour role (3/6)
Also, many thanks to the incredible group of people that form my team, for their input and assistance along the way and for the great working atmosphere. And to @fendtlab.bsky.social) for hosting Bea and helping us in this project (2/6)
March 25, 2025 at 8:35 AM
Also, many thanks to the incredible group of people that form my team, for their input and assistance along the way and for the great working atmosphere. And to @fendtlab.bsky.social) for hosting Bea and helping us in this project (2/6)