ALERTA de EMPLEO!! Ofrecemos un contrato predoctoral para realizar la tesis doctoral en el estudio de la heterogeneidad funcional de los fibroblastos asociados a cáncer (CAFs) y su papel en resistencia terapéutica en cáncer de vejiga, asociado a nuestro proyecto (PID2024-157801OB-I00). Más detalles👇

Amazing master lecture on clinical genomics by the great Angel Carracedo visiting us today at @ibbtec.bsky.social. Learned a lot.

JOB ALERT!! 🧪 We are offering a postdoc position within our “antiCAFing” ERC-CoG project to investigate the interplay CAFs:endothelial cells and its impact in aberrant vascularization in tumors. More details below 👇. Please spread the word.

This mechanism was validated in non-tumoral contexts employing emergent vasculogenesis models in microfluidic devices, underscoring the broader relevance of the HSP90α-YAP axis beyond CAFs.
6/11

We identify the mechanotransducer YAP as a key effector of HSP90α. YAP is activated in CAFs through mechanotransduction, playing a critical role in CAF function. e show that HSP90α depletion compromises YAP stability, and that YAP is the main mediator of HSP90α functions in CAFs.
5/11

Our findings reveal a crucial role for the master chaperone HSP90α in shaping CAF functionality, influencing extracellular matrix (ECM) remodelling, tumour growth, and dissemination in experimental breast cancer models.
4/11

Through comprehensive gene expression analyses of human cancer stroma + unbiased chemical genomics approaches, we show that HSP90-dependent transcriptional programs are a consistent feature of CAFs associated with aggressive #TME and poor patient prognosis.
2/11

Also, many thanks to the incredible group of people that form my team, for their input and assistance along the way and for the great working atmosphere. And to @fendtlab.bsky.social) for hosting Bea and helping us in this project (2/6)

New PhD in the CalvoLab! Congratulations to Beatriz Rodriguez Coursier for her amazing work defending her PhD project. Thanks to the evaluating panel for the discussion and comments (Adan Pinto, Ana Villar, Esther Castellano)(1/6)

Also, many thanks to my sidewinder Javier Rodriguez for his inputs, assistance and co-direction, and to Emad Moeendarbary that helped us along the way. Also, a good time to reflect on the incredible group of people that form my team.

New PhD in the CalvoLab! Congratulations to Diane Coursier for her great work defending her PhD project. Thanks to the evaluating panel for the discussion and comments (Alessandro Fantin, Ana Cuenda and Javier Leon).