Congratulations to all authors! This work was supported by several federal and private research grants. We thank the patients and families for their participation.

@columbiauniversity.bsky.social

... isogenic iPSC-derived human cells, mouse models, and #human brain tissues show the universal importance and validity of these disease pathways. Targeting these pathologies may open promising therapeutic avenues to slow #Alzheimer’s disease progression.

This rigidity may exacerbate the breakdown blood-brain barrier, an important structure regulating the clearance and basic health of the #brain. Our results provide further evidence linking vascular pathology to AD progression. Our validation in other large cohorts, ++

We identified unique molecular changes in various cell types that regulate the interaction between brain cells and blood vessels. An important cell type, #astrocytes, adopt a hyper-adhesive, mechanically rigid states at the #vascular interface with #APOE-ε4.

Thank you Jingli🥰

This was a collaborative effort from teams at @karolinskainst.bsky.social and @columbiauniversity.bsky.social. Congratulations to all authors, including our own @elanuryilmaz.bsky.social and Prabesh Bhattarai! 🙌

Thanks for the generous support of our funding agencies 🙏

Why it matters:
This research challenges the idea that the heart is just a simple relay, positioning the IcNS as a key player in rhythm generation. A leap toward new therapeutic strategies for arrhythmia and heart failure.

🔑Highlights:
- Pacemaker-like neurons in the IcNS, generating rhythmic activity autonomously 🧠💓
- A complex diversity of neurotransmitter systems finely tuning heart rhythms 🔬
- Ex-vivo study of intact neural heart networks 🧪

Congratulations to all authors and thanks to supporting agencies.