Buszczak Lab
@buszczaklab.bsky.social
Department of Molecular Biology at UT Southwestern. Interested in Genetics, Developmental Biology, Ribosomes, mRNA Translation.
Reposted by Buszczak Lab
ONLINE NOW: CRI's Ohlstein Lab presents new research that reevaluates whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila, in @pnas.org. Read more ⬇️ www.pnas.org/doi/10.1073/...
#relentlessdiscovery 🧪
#relentlessdiscovery 🧪
Reevaluation of whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila | PNAS
Recent work suggests that asymmetric segregation of preexisting and newly synthesized
canonical histone 3.1 (H3.1), but not variant histone 3.3A (H...
www.pnas.org
October 31, 2025 at 2:31 PM
ONLINE NOW: CRI's Ohlstein Lab presents new research that reevaluates whether histones are asymmetrically segregated during asymmetric divisions of stem cells in Drosophila, in @pnas.org. Read more ⬇️ www.pnas.org/doi/10.1073/...
#relentlessdiscovery 🧪
#relentlessdiscovery 🧪
Reposted by Buszczak Lab
Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
Oxidative stress sensing by the translation elongation machinery promotes production of detoxifying selenoproteins
Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...
www.biorxiv.org
October 14, 2025 at 10:28 PM
Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
Reposted by Buszczak Lab
Science has already saved countless lives and will save many more if we let it. Hearing firsthand from patients whose lives have been saved by medical research (tinyurl.com/m65339fh) shows how vital this funding is, even for those lucky enough not to have needed it yet.
Please share
#ScienceSavedMe
Please share
#ScienceSavedMe
September 3, 2025 at 10:12 PM
Science has already saved countless lives and will save many more if we let it. Hearing firsthand from patients whose lives have been saved by medical research (tinyurl.com/m65339fh) shows how vital this funding is, even for those lucky enough not to have needed it yet.
Please share
#ScienceSavedMe
Please share
#ScienceSavedMe
Excited to announce our paper describing how allelic variants in ribosome biogenesis factors cause neurodevelopmental disorders. Congratulations to Chunyang Ni, Yudong Wei and Barbara Vona, our collaborators Jun Wu, Reza Maroofian, and Leqian Yu, and all the other authors from across the globe.
A programmed decline in ribosome levels governs human early neurodevelopment - Nature Cell Biology
Ni, Wei, Vona and colleagues use human brain organoids to dissect patient AIRIM variants associated with neurodevelopmental features. A subset of variants impaired ribosome production and protein synt...
www.nature.com
August 4, 2025 at 4:33 PM
Excited to announce our paper describing how allelic variants in ribosome biogenesis factors cause neurodevelopmental disorders. Congratulations to Chunyang Ni, Yudong Wei and Barbara Vona, our collaborators Jun Wu, Reza Maroofian, and Leqian Yu, and all the other authors from across the globe.