Marian Burr
@burrlab.bsky.social
Cancer Researcher, Head of Cancer Immunology and Epigenetics Lab @ ANU, Pathologist, Australia
https://jcsmr.anu.edu.au/research/groups/burr-group-cancer-immunology-and-epigenetics
https://jcsmr.anu.edu.au/research/groups/burr-group-cancer-immunology-and-epigenetics
Reposted by Marian Burr
Check out this 🧵 from @eimearlagan.bsky.social on our new Molecular Cell @cp-molcell.bsky.social paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇
Excited to share our new paper out today in @cp-molcell.bsky.social! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).
May 21, 2025 at 5:22 PM
Check out this 🧵 from @eimearlagan.bsky.social on our new Molecular Cell @cp-molcell.bsky.social paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇
Reposted by Marian Burr
Delighted to share the latest preprint from the lab led by Janith Seneviratne
We reveal novel roles for #embryonic regulators DPPA2/4 in facilitating a H2AK119Ub primed #chromatin state when aberrantly up-regulated in non-small cell lung #cancers 🧬🔬 (1/6)
www.biorxiv.org/content/10.1...
We reveal novel roles for #embryonic regulators DPPA2/4 in facilitating a H2AK119Ub primed #chromatin state when aberrantly up-regulated in non-small cell lung #cancers 🧬🔬 (1/6)
www.biorxiv.org/content/10.1...
April 28, 2025 at 11:07 AM
Delighted to share the latest preprint from the lab led by Janith Seneviratne
We reveal novel roles for #embryonic regulators DPPA2/4 in facilitating a H2AK119Ub primed #chromatin state when aberrantly up-regulated in non-small cell lung #cancers 🧬🔬 (1/6)
www.biorxiv.org/content/10.1...
We reveal novel roles for #embryonic regulators DPPA2/4 in facilitating a H2AK119Ub primed #chromatin state when aberrantly up-regulated in non-small cell lung #cancers 🧬🔬 (1/6)
www.biorxiv.org/content/10.1...
Reposted by Marian Burr
Read the paper here! www.biorxiv.org/content/10.1...
Congrats to Janith and the rest of the lab @petermaccc.bsky.social, and thanks to collaborators Shabih Shakeel @wehi-research.bsky.social, @benparkerlab.bsky.social and @burrlab.bsky.social, and ongoing support from @snowmedical.bsky.social
(6/6)
Congrats to Janith and the rest of the lab @petermaccc.bsky.social, and thanks to collaborators Shabih Shakeel @wehi-research.bsky.social, @benparkerlab.bsky.social and @burrlab.bsky.social, and ongoing support from @snowmedical.bsky.social
(6/6)
Embryonic stem cell factors DPPA2/4 facilitate a unique chromatin state in non-small cell lung cancer
Embryonic regulators are often re-expressed in cancers, however the functional and molecular significance of this is not always understood. The epigenetic priming factors Developmental Pluripotency As...
www.biorxiv.org
April 28, 2025 at 11:07 AM
Read the paper here! www.biorxiv.org/content/10.1...
Congrats to Janith and the rest of the lab @petermaccc.bsky.social, and thanks to collaborators Shabih Shakeel @wehi-research.bsky.social, @benparkerlab.bsky.social and @burrlab.bsky.social, and ongoing support from @snowmedical.bsky.social
(6/6)
Congrats to Janith and the rest of the lab @petermaccc.bsky.social, and thanks to collaborators Shabih Shakeel @wehi-research.bsky.social, @benparkerlab.bsky.social and @burrlab.bsky.social, and ongoing support from @snowmedical.bsky.social
(6/6)