@Bruskolab
@bruskolab.bsky.social
Professor, Director of the University of Florida Diabetes Institute. Father, immunologist, and proponent of evidence-based medicine. All opinions are my own.
Reposted by @Bruskolab
Engineered β cells with a mutant CD155 help evade immune attack, offering a promising therapeutic approach for type 1 diabetes @bruskolab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Human stem cell-derived β cells expressing an optimized CD155 reduce cytotoxic immune cell function for application in type 1 diabetes
Engineered β cells with a mutant CD155 help evade immune attack, offering a promising therapeutic approach for type 1 diabetes.
www.science.org
November 7, 2025 at 9:30 PM
Engineered β cells with a mutant CD155 help evade immune attack, offering a promising therapeutic approach for type 1 diabetes @bruskolab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by @Bruskolab
@biorxivpreprint.bsky.social High-affinity CD155 expression enhances immune evasion of Stem cell-derived β-cells, improving their potential for restorative therapy in type 1 diabetes @bruskolab.bsky.social @mebrown4.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 16, 2025 at 4:23 AM
@biorxivpreprint.bsky.social High-affinity CD155 expression enhances immune evasion of Stem cell-derived β-cells, improving their potential for restorative therapy in type 1 diabetes @bruskolab.bsky.social @mebrown4.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by @Bruskolab
Early identification of pre-clinical type 1 #diabetes combining autoantibody screening and metabolic monitoring at a single centre fully prevented #DKA at disease onset in relatives of affected patients. #T1D #DiabetesResearch link.springer.com/article/10.1... 🔓
Prevention of diabetic ketoacidosis in relatives screened for islet autoantibodies and followed up in the TrialNet Pathway to Prevention study at a single institution in Italy - Diabetologia
Aims/hypothesis Screening for islet autoantibodies is an effective method for identifying individuals with pre-symptomatic (stage 1 and 2) type 1 diabetes. This approach offers a valuable opportunity ...
link.springer.com
June 6, 2025 at 6:04 AM
Early identification of pre-clinical type 1 #diabetes combining autoantibody screening and metabolic monitoring at a single centre fully prevented #DKA at disease onset in relatives of affected patients. #T1D #DiabetesResearch link.springer.com/article/10.1... 🔓
Our latest preprint on cellular and molecular phenotypes in T1D is out now. www.biorxiv.org/content/10.1...
Aberrant immune regulation and enrichment of stem-like CD8+ T cells in the pancreatic lymph node during type 1 diabetes development
Effector CD8+ T cells are key cellular drivers of type 1 diabetes (T1D) pathogenesis, yet questions remain regarding the molecular defects leading to altered cytotoxicity, their signature in periphera...
www.biorxiv.org
May 28, 2025 at 10:24 AM
Our latest preprint on cellular and molecular phenotypes in T1D is out now. www.biorxiv.org/content/10.1...
🚨New work from our lab with important clinical implications. Thanks to our collaborators in @TheHPAP. Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes | bioRxiv
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes
This study explores the inflammatory response observed in pancreata and pancreatic lymph node (pLN) samples obtained throughout the natural history of type 1 diabetes (T1D) including non-diabetic indi...
www.biorxiv.org
May 25, 2025 at 12:26 PM
🚨New work from our lab with important clinical implications. Thanks to our collaborators in @TheHPAP. Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes | bioRxiv
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
This paper from cancer should be read by all as a challenge to conventional dogmas. journals.plos.org/plosbiology/...
The end of the genetic paradigm of cancer
Genome sequencing results and single-cell transcriptomics continue to produce findings that challenge the idea that cancer is purely a ‘genetic disease’. This Essay delves into cancer omics data that ...
journals.plos.org
March 22, 2025 at 9:35 PM
This paper from cancer should be read by all as a challenge to conventional dogmas. journals.plos.org/plosbiology/...
Reposted by @Bruskolab
Science, folks. Science. This is wonderful news.
March 15, 2025 at 4:02 PM
Science, folks. Science. This is wonderful news.
Reposted by @Bruskolab
🎉FOCIS is celebrating 25 years of innovation and impact! 🎉
This June, we’re marking a milestone in our journey of embracing diverse perspectives and fostering global collaboration. 🌍✨
Learn more about what’s coming 👉 zurl.co/iFu1c
#FOCIS2025 #Celebrating25Years
This June, we’re marking a milestone in our journey of embracing diverse perspectives and fostering global collaboration. 🌍✨
Learn more about what’s coming 👉 zurl.co/iFu1c
#FOCIS2025 #Celebrating25Years
March 7, 2025 at 7:21 PM
🎉FOCIS is celebrating 25 years of innovation and impact! 🎉
This June, we’re marking a milestone in our journey of embracing diverse perspectives and fostering global collaboration. 🌍✨
Learn more about what’s coming 👉 zurl.co/iFu1c
#FOCIS2025 #Celebrating25Years
This June, we’re marking a milestone in our journey of embracing diverse perspectives and fostering global collaboration. 🌍✨
Learn more about what’s coming 👉 zurl.co/iFu1c
#FOCIS2025 #Celebrating25Years
If I did not worry about future prospects for my trainees, I don’t think I would ever publish beyond pre-prints unless there were free open-access society journals.
February 28, 2025 at 8:16 AM
If I did not worry about future prospects for my trainees, I don’t think I would ever publish beyond pre-prints unless there were free open-access society journals.
Reposted by @Bruskolab
Extremely pleased to share our new work in collaboration with the @bruskolab.bsky.social lab, where we leveraged one of the largest TCRbeta sequencing datasets to identify T1D-associated TCR-based signatures. Paper link and 🧵 are below. Incredible work led by @puneet021192.bsky.social.
Happy to share our new collaborative work! 🚨 We analyzed 2250 TCR repertoires to uncover how HLA risk alleles shape immune autoreactivity in T1D. T1D-specific HLA-motifs were also validated in pancreatic lymph nodes (pLN) & spleen. 🧬🧵 #T1D #Immunology #TCR 1/9
December 15, 2024 at 7:52 AM
Extremely pleased to share our new work in collaboration with the @bruskolab.bsky.social lab, where we leveraged one of the largest TCRbeta sequencing datasets to identify T1D-associated TCR-based signatures. Paper link and 🧵 are below. Incredible work led by @puneet021192.bsky.social.
Therapeutic targeting of the T1D-associated costimulatory molecule CD226.
rdcu.be/d2A3k
rdcu.be/d2A3k
Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function
rdcu.be
December 6, 2024 at 9:58 AM
Therapeutic targeting of the T1D-associated costimulatory molecule CD226.
rdcu.be/d2A3k
rdcu.be/d2A3k
I clearly feel more comfortable on the water than in the Arizona desert but it was a fun Thanksgiving in both places.
November 30, 2024 at 11:10 PM
I clearly feel more comfortable on the water than in the Arizona desert but it was a fun Thanksgiving in both places.
Reposted by @Bruskolab
I was honored to talk to @evartesfaye.bsky.social about one community’s effort to stay put in the face of climate change.
“The oyster reef is a living thing. … When the sea level rises, because oysters are growing on it, it will grow vertically as well, so it will continue to add protection.” — me
“The oyster reef is a living thing. … When the sea level rises, because oysters are growing on it, it will grow vertically as well, so it will continue to add protection.” — me
Along Louisiana’s coast, tribes are witnessing their lands disappear underwater.
Environment reporter Eva Tesfaye joins us to discuss how the Atakapa-Ishak/Chawasha tribe is creating protective reefs using recycled oyster shells.
Environment reporter Eva Tesfaye joins us to discuss how the Atakapa-Ishak/Chawasha tribe is creating protective reefs using recycled oyster shells.
Using Oyster Shell Reefs To Counter Sea Level Rise In Louisiana
Tribes’ historic lands on the Gulf Coast are being lost to the sea. To slow it down, one tribe has turned to oyster shells.
www.sciencefriday.com
November 22, 2024 at 11:37 PM
I was honored to talk to @evartesfaye.bsky.social about one community’s effort to stay put in the face of climate change.
“The oyster reef is a living thing. … When the sea level rises, because oysters are growing on it, it will grow vertically as well, so it will continue to add protection.” — me
“The oyster reef is a living thing. … When the sea level rises, because oysters are growing on it, it will grow vertically as well, so it will continue to add protection.” — me
Please join us for this amazing event. Looking forward to seeing these talks. @ufdiabetes @breakthrought1d.bsky.social
November 21, 2024 at 4:50 PM
Please join us for this amazing event. Looking forward to seeing these talks. @ufdiabetes @breakthrought1d.bsky.social
Looking forward to seeing more science, less garbage.
September 15, 2024 at 11:57 PM
Looking forward to seeing more science, less garbage.