Tony Bruns (Bruns Lab Aachen)
@brunslab.bsky.social
Liver Disease Research. Our primary objective is to improve patient care focussing on the gut-liver axis in cirrhosis, peritoneal immunity & spontaneous bacterial peritonitis, acute-on-chronic liver failure, and cirrhosis-related immune dysfunction.
Reposted by Tony Bruns (Bruns Lab Aachen)
At the beautiful European mucosal immunology group conference #emig in Aachen ready for two days of great #mucosalimmunology sciences #interferosky #gastrosky 🧪
July 21, 2025 at 7:57 AM
At the beautiful European mucosal immunology group conference #emig in Aachen ready for two days of great #mucosalimmunology sciences #interferosky #gastrosky 🧪
Reposted by Tony Bruns (Bruns Lab Aachen)
🔥 We’ve hit 50% recruitment in the #COMBATtrial!
Huge thanks to all involved!💙
@rautoupe.bsky.social @hopitalbeaujon.bsky.social @hospitalclinic.bsky.social @rwth.bsky.social @uni-muenster.de @brunslab.bsky.social @medblab.bsky.social @frankuschner.bsky.social
#LiverSky #ClinicalTrial
Huge thanks to all involved!💙
@rautoupe.bsky.social @hopitalbeaujon.bsky.social @hospitalclinic.bsky.social @rwth.bsky.social @uni-muenster.de @brunslab.bsky.social @medblab.bsky.social @frankuschner.bsky.social
#LiverSky #ClinicalTrial
June 30, 2025 at 3:55 PM
🔥 We’ve hit 50% recruitment in the #COMBATtrial!
Huge thanks to all involved!💙
@rautoupe.bsky.social @hopitalbeaujon.bsky.social @hospitalclinic.bsky.social @rwth.bsky.social @uni-muenster.de @brunslab.bsky.social @medblab.bsky.social @frankuschner.bsky.social
#LiverSky #ClinicalTrial
Huge thanks to all involved!💙
@rautoupe.bsky.social @hopitalbeaujon.bsky.social @hospitalclinic.bsky.social @rwth.bsky.social @uni-muenster.de @brunslab.bsky.social @medblab.bsky.social @frankuschner.bsky.social
#LiverSky #ClinicalTrial
Reposted by Tony Bruns (Bruns Lab Aachen)
Check out this electric insight from our Rising Star 2025, Carolin Schneider!
⭐ UEG Rising Star Awards are annually given to 10 of the most promising, emerging scientists. 🏆
🏆 Access Carolin's publication: https://bit.ly/3DDKzdX
#myUEGcommunity
⭐ UEG Rising Star Awards are annually given to 10 of the most promising, emerging scientists. 🏆
🏆 Access Carolin's publication: https://bit.ly/3DDKzdX
#myUEGcommunity
May 12, 2025 at 9:00 AM
Check out this electric insight from our Rising Star 2025, Carolin Schneider!
⭐ UEG Rising Star Awards are annually given to 10 of the most promising, emerging scientists. 🏆
🏆 Access Carolin's publication: https://bit.ly/3DDKzdX
#myUEGcommunity
⭐ UEG Rising Star Awards are annually given to 10 of the most promising, emerging scientists. 🏆
🏆 Access Carolin's publication: https://bit.ly/3DDKzdX
#myUEGcommunity
Reposted by Tony Bruns (Bruns Lab Aachen)
💉 Albumin duration & AKI response in cirrhosis
Eva M. Schleicher (Mainz) – #EASL2025
🕒 24h albumin new rule questioned
🏆 EASL AKI response definition wins
📈 20% of 24h NR improved at 48h
⚖️ Early vs late responders: Same mortality
🚨 Cr ↑ >16% @24h → terlipressin!
👇
Eva M. Schleicher (Mainz) – #EASL2025
🕒 24h albumin new rule questioned
🏆 EASL AKI response definition wins
📈 20% of 24h NR improved at 48h
⚖️ Early vs late responders: Same mortality
🚨 Cr ↑ >16% @24h → terlipressin!
👇
May 9, 2025 at 3:02 PM
💉 Albumin duration & AKI response in cirrhosis
Eva M. Schleicher (Mainz) – #EASL2025
🕒 24h albumin new rule questioned
🏆 EASL AKI response definition wins
📈 20% of 24h NR improved at 48h
⚖️ Early vs late responders: Same mortality
🚨 Cr ↑ >16% @24h → terlipressin!
👇
Eva M. Schleicher (Mainz) – #EASL2025
🕒 24h albumin new rule questioned
🏆 EASL AKI response definition wins
📈 20% of 24h NR improved at 48h
⚖️ Early vs late responders: Same mortality
🚨 Cr ↑ >16% @24h → terlipressin!
👇
Reposted by Tony Bruns (Bruns Lab Aachen)
Back in the Abstract Session: Theresa Wirtz presents her scRNA-seq work on monocyte subsets and ACLF risk.
@rwth.bsky.social
@brunslab.bsky.social
@easlnews.bsky.social
#Cirrhosis #ACLF #EASL2025"
@rwth.bsky.social
@brunslab.bsky.social
@easlnews.bsky.social
#Cirrhosis #ACLF #EASL2025"
May 10, 2025 at 8:58 AM
Back in the Abstract Session: Theresa Wirtz presents her scRNA-seq work on monocyte subsets and ACLF risk.
@rwth.bsky.social
@brunslab.bsky.social
@easlnews.bsky.social
#Cirrhosis #ACLF #EASL2025"
@rwth.bsky.social
@brunslab.bsky.social
@easlnews.bsky.social
#Cirrhosis #ACLF #EASL2025"
Reposted by Tony Bruns (Bruns Lab Aachen)
🦠The recovery failure of fecal microbiota diversity in patients after liver transplant is associated with a complicated postoperative course
#POSTER SAT-518 by @beccsipollsi.bsky.social from @rwth.bsky.social at #EASL2025
@brunslab.bsky.social
@easlnews.bsky.social
#POSTER SAT-518 by @beccsipollsi.bsky.social from @rwth.bsky.social at #EASL2025
@brunslab.bsky.social
@easlnews.bsky.social
May 10, 2025 at 10:35 AM
🦠The recovery failure of fecal microbiota diversity in patients after liver transplant is associated with a complicated postoperative course
#POSTER SAT-518 by @beccsipollsi.bsky.social from @rwth.bsky.social at #EASL2025
@brunslab.bsky.social
@easlnews.bsky.social
#POSTER SAT-518 by @beccsipollsi.bsky.social from @rwth.bsky.social at #EASL2025
@brunslab.bsky.social
@easlnews.bsky.social
Reposted by Tony Bruns (Bruns Lab Aachen)
Congrats on presenting your poster in the Track Hub 4 this afternoon, @beccsipollsi.bsky.social ! 🙌
May 9, 2025 at 2:45 PM
Congrats on presenting your poster in the Track Hub 4 this afternoon, @beccsipollsi.bsky.social ! 🙌
Reposted by Tony Bruns (Bruns Lab Aachen)
Next at the DECISION Networking Session at #EASL2025, Theresa Wirtz (UKA) presents scRNA-seq data showing a monocyte subset linked to ACLF risk.
Fascinating translational science in action!
@brunslab.bsky.social ky.social @easlnews.bsky.social ky.social
#scRNAseq #ACLF
Fascinating translational science in action!
@brunslab.bsky.social ky.social @easlnews.bsky.social ky.social
#scRNAseq #ACLF
May 9, 2025 at 8:09 AM
Next at the DECISION Networking Session at #EASL2025, Theresa Wirtz (UKA) presents scRNA-seq data showing a monocyte subset linked to ACLF risk.
Fascinating translational science in action!
@brunslab.bsky.social ky.social @easlnews.bsky.social ky.social
#scRNAseq #ACLF
Fascinating translational science in action!
@brunslab.bsky.social ky.social @easlnews.bsky.social ky.social
#scRNAseq #ACLF
Reposted by Tony Bruns (Bruns Lab Aachen)
📣 ICA GLOBAL AKI study published in @lancetgastrohep.bsky.social
🗺️3,821 patients with cirrhosis
✅38% had AKI
⚠️discrepancies in AKI management and outcomes
⚠️ AKI ➡️22.9% 28-day mortality
🎯Need for equitable & standardized care
www.thelancet.com/journals/lan...
🗺️3,821 patients with cirrhosis
✅38% had AKI
⚠️discrepancies in AKI management and outcomes
⚠️ AKI ➡️22.9% 28-day mortality
🎯Need for equitable & standardized care
www.thelancet.com/journals/lan...
Global epidemiology of acute kidney injury in hospitalised patients with decompensated cirrhosis: the International Club of Ascites GLOBAL AKI prospective, multicentre, cohort study
This study found important regional differences in AKI severity, phenotype, management,
and outcomes in patients with decompensated cirrhosis. Health-care coverage remains
an important driver of survi...
www.thelancet.com
March 11, 2025 at 3:52 PM
📣 ICA GLOBAL AKI study published in @lancetgastrohep.bsky.social
🗺️3,821 patients with cirrhosis
✅38% had AKI
⚠️discrepancies in AKI management and outcomes
⚠️ AKI ➡️22.9% 28-day mortality
🎯Need for equitable & standardized care
www.thelancet.com/journals/lan...
🗺️3,821 patients with cirrhosis
✅38% had AKI
⚠️discrepancies in AKI management and outcomes
⚠️ AKI ➡️22.9% 28-day mortality
🎯Need for equitable & standardized care
www.thelancet.com/journals/lan...
Immunology research on bacterial infections in patients with cirrhosis: The human inflammatory caspases 4 and 5 are differentially regulated in patients with immune dysfunction due to sepsis and In acute-on-chronic liver failure. www.frontiersin.org/articles/10....
The non-canonical inflammasome activators Caspase-4 and Caspase-5 are differentially regulated durin...
The non-canonical inflammasome, which includes caspase-11 in mice and caspase-4 and caspase-5 in humans, is upregulated during inflammatory processes and activated in response to bacterial infections ...
www.frontiersin.org
December 24, 2023 at 8:04 PM
Immunology research on bacterial infections in patients with cirrhosis: The human inflammatory caspases 4 and 5 are differentially regulated in patients with immune dysfunction due to sepsis and In acute-on-chronic liver failure. www.frontiersin.org/articles/10....