Brooke O'Donnell
@brookeodonnell.bsky.social
PhD👩🏼🔬🇨🇦 | Post-doctoral Fellow | Isakson Laboratory | CVRC University of Virginia 🧡💙 (she/her)
Thanks to @UVACVRC for the shoutout! Happy National Postdoc Appreciation Week 🎉
Brooke O'Donnell, PhD, works at the molecular level to understand how Pannexin proteins affect blood pressure, blood flow, and blood vessel dilation. @brookeodonnell.bsky.social is also a hockey player, reader, and the @brantisakson.bsky.social Lab's resident tea evangelist.
September 17, 2025 at 6:49 PM
Thanks to @UVACVRC for the shoutout! Happy National Postdoc Appreciation Week 🎉
Reposted by Brooke O'Donnell
The official release of our manuscript examining arterial myocyte Panx1 role in diabetic vascular dysfunction is out! Massive effort to uncover new mechanisms underlying vascular disease. Power of science! @ucdavis.bsky.social, @ucdavispharm.bsky.social
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia | Circulation Research
BACKGROUND: Diabetic hyperglycemia promotes vasoconstriction by activating an ATP-dependent P2Y11L (P2Y11-like receptor)/AC5 (adenylyl cyclase 5)/AKAP5 (A-kinase anchoring protein 5)/PKA
(protein kina...
www.ahajournals.org
August 15, 2025 at 2:18 PM
The official release of our manuscript examining arterial myocyte Panx1 role in diabetic vascular dysfunction is out! Massive effort to uncover new mechanisms underlying vascular disease. Power of science! @ucdavis.bsky.social, @ucdavispharm.bsky.social
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
Grateful to have been a part of this exciting story!
Excited to pre-release the latest from the lab on how arterial myocyte Panx1 controls vascular reactivity in diabetes. Massive effort from the M&M Team in collaboration with @brantisakson.bsky.social and Xiang Lab
Check our latest work from the M&M lab on the role of SMC Pannexin 1 in diabetic hyperglycemia! And thanks to everyone involved in this! Ole 💃 www.ahajournals.org/doi/10.1161/...
July 10, 2025 at 11:06 PM
Grateful to have been a part of this exciting story!
Reposted by Brooke O'Donnell
Some of the strong work by Melissa Luse rounding her PhD. Love the story, and I think it opens up some new ideas in endothelial lipid handling and overall questions roles for NO…
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
Nitrosation of CD36 Regulates Endothelial Function and Serum Lipids | Arteriosclerosis, Thrombosis, and Vascular Biology
BACKGROUND: During obesity, endothelial cells (ECs) become lipid laden, leading to endothelial
dysfunction. We tested posttranslational modification on CD36 that may regulate EC
lipid accumulation. ...
www.ahajournals.org
April 21, 2025 at 3:03 PM
Some of the strong work by Melissa Luse rounding her PhD. Love the story, and I think it opens up some new ideas in endothelial lipid handling and overall questions roles for NO…
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
Was great to be back for the 13th Conference on Signalling in Normal and Cancer Cells to present my work on the effect of PANX1 phosphorylation in the vasculature 🍁 thanks to the organizers @jf-cotelab.bsky.social for a great week and my previous lab mates @drsilviapenuela.bsky.social for the visit!
April 1, 2025 at 1:05 PM
Was great to be back for the 13th Conference on Signalling in Normal and Cancer Cells to present my work on the effect of PANX1 phosphorylation in the vasculature 🍁 thanks to the organizers @jf-cotelab.bsky.social for a great week and my previous lab mates @drsilviapenuela.bsky.social for the visit!