Brian DeFelice
@briancdefelice.bsky.social
Father, scientist (#TeamMassSpec), metabolomics/lipidomics, snowboarder, dog lover, CZ Biohub, Fiehn Lab alum
Reposted by Brian DeFelice
Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!
shorturl.at/B5XYD
shorturl.at/B5XYD
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 8:45 PM
Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!
shorturl.at/B5XYD
shorturl.at/B5XYD
Reposted by Brian DeFelice
Interested in a co-authorship?
We’re building a tool for repository-scale untargeted #metabolomics and #exposomics of #environmental data. To make it the best it can be, we’re looking for people willing to share high-resolution LC-MS/MS (DDA) data from #water, #soil, #sediment, and related samples.
We’re building a tool for repository-scale untargeted #metabolomics and #exposomics of #environmental data. To make it the best it can be, we’re looking for people willing to share high-resolution LC-MS/MS (DDA) data from #water, #soil, #sediment, and related samples.
August 26, 2025 at 7:51 PM
Interested in a co-authorship?
We’re building a tool for repository-scale untargeted #metabolomics and #exposomics of #environmental data. To make it the best it can be, we’re looking for people willing to share high-resolution LC-MS/MS (DDA) data from #water, #soil, #sediment, and related samples.
We’re building a tool for repository-scale untargeted #metabolomics and #exposomics of #environmental data. To make it the best it can be, we’re looking for people willing to share high-resolution LC-MS/MS (DDA) data from #water, #soil, #sediment, and related samples.
Reposted by Brian DeFelice
Join us at Metabolomics 2025 for our workshop -> W10: EMN – MetaboMentors!
Grow as a mentor or mentee through insights, tools & global perspectives.
📅 Monday, June 23rd, 8:15 - 10:15 in South Hall 2
🔗 www.metabolomics2025.org/workshops
🎤 #EMN #MetaboMentors #Mentorship #Metabolomics2025
Grow as a mentor or mentee through insights, tools & global perspectives.
📅 Monday, June 23rd, 8:15 - 10:15 in South Hall 2
🔗 www.metabolomics2025.org/workshops
🎤 #EMN #MetaboMentors #Mentorship #Metabolomics2025
June 10, 2025 at 2:40 PM
Join us at Metabolomics 2025 for our workshop -> W10: EMN – MetaboMentors!
Grow as a mentor or mentee through insights, tools & global perspectives.
📅 Monday, June 23rd, 8:15 - 10:15 in South Hall 2
🔗 www.metabolomics2025.org/workshops
🎤 #EMN #MetaboMentors #Mentorship #Metabolomics2025
Grow as a mentor or mentee through insights, tools & global perspectives.
📅 Monday, June 23rd, 8:15 - 10:15 in South Hall 2
🔗 www.metabolomics2025.org/workshops
🎤 #EMN #MetaboMentors #Mentorship #Metabolomics2025
Awesome technology and application! Viral infection mediates astounding protein relocalization. I wonder, what else might be moving around when cells are infected?
Our approach resolves proteomics dynamics. Check out how the proteome is remodeled upon infection with HCoV-OC43.
Turns out that protein relocalization is largely orthogonal to regulation at the protein abundance level.
2/3
Turns out that protein relocalization is largely orthogonal to regulation at the protein abundance level.
2/3
January 14, 2025 at 4:47 PM
Awesome technology and application! Viral infection mediates astounding protein relocalization. I wonder, what else might be moving around when cells are infected?
Great way for early career folks to contribute to the field and make connections with editors
Just saying... MANA ECM is always ready 😀
forms.gle/TKNLx9aWbtNs...
forms.gle/TKNLx9aWbtNs...
MANA Early Career Members Network peer-review sign-up!
The MANA ECM has created a living spreadsheet in an effort to address the shortage of peer-reviewers in metabolomics and to provide opportunities and experience for early-career researchers to serve a...
forms.gle
December 12, 2024 at 4:35 PM
Great way for early career folks to contribute to the field and make connections with editors
If your lab is using a Thermo LCMS consider trying our tool Rapid QC-MS for automated QC of internal and external standards. Check out our recent publication in Analytical Chemistry: doi.org/10.1021/acs....
Git: github.com/czbiohub-sf/...
User guide: czbiohub-sf.github.io/Rapid-QC-MS/ #OpenScience
Git: github.com/czbiohub-sf/...
User guide: czbiohub-sf.github.io/Rapid-QC-MS/ #OpenScience
Rapid QC-MS: Interactive Dashboard for Synchronous Mass Spectrometry Data Acquisition Quality Control
Consistently collecting high-quality liquid chromatography-coupled tandem mass spectrometry (LC-MS/MS) data is a time-consuming hurdle for untargeted workflows. Analytical controls such as internal an...
doi.org
December 4, 2024 at 12:18 AM
If your lab is using a Thermo LCMS consider trying our tool Rapid QC-MS for automated QC of internal and external standards. Check out our recent publication in Analytical Chemistry: doi.org/10.1021/acs....
Git: github.com/czbiohub-sf/...
User guide: czbiohub-sf.github.io/Rapid-QC-MS/ #OpenScience
Git: github.com/czbiohub-sf/...
User guide: czbiohub-sf.github.io/Rapid-QC-MS/ #OpenScience