Caroline (Lindy) Rae
@brainmetabolism.bsky.social
Neurochemist, MRI afficionado, she/her. Dedicated theobrominian
Just published ! Two chapters encapsulating the idea of constrained brain energy metabolism that lies at the heart of brain vulnerability in aging, development and stress. Result of a week's hard work at the Ernst Strüngmann forum.
rdcu.be/eJvXK
rdcu.be/eJv3I
rdcu.be/eJvXK
rdcu.be/eJv3I
Brain Energy Production Vulnerability and Pathophysiology
rdcu.be
October 5, 2025 at 12:56 AM
Just published ! Two chapters encapsulating the idea of constrained brain energy metabolism that lies at the heart of brain vulnerability in aging, development and stress. Result of a week's hard work at the Ernst Strüngmann forum.
rdcu.be/eJvXK
rdcu.be/eJv3I
rdcu.be/eJvXK
rdcu.be/eJv3I
Super pleased to have finally published our latest neurochemistry review on the many and varied roles of aspartate in brain.
rdcu.be/eqMHd
rdcu.be/eqMHd
June 13, 2025 at 7:38 AM
Super pleased to have finally published our latest neurochemistry review on the many and varied roles of aspartate in brain.
rdcu.be/eqMHd
rdcu.be/eqMHd
New paper showing a key component of the glutamate-glutamine cycle. NTT4 (SLC6A17) supplies Gln for the presynaptic production of Glu. Needed to sustain rapid ongoing excitatory synaptic transmission and has roles in memory formation and other behaviours.
doi.org/10.1016/j.pneurobio.2025.102785
doi.org/10.1016/j.pneurobio.2025.102785
May 29, 2025 at 12:07 AM
New paper showing a key component of the glutamate-glutamine cycle. NTT4 (SLC6A17) supplies Gln for the presynaptic production of Glu. Needed to sustain rapid ongoing excitatory synaptic transmission and has roles in memory formation and other behaviours.
doi.org/10.1016/j.pneurobio.2025.102785
doi.org/10.1016/j.pneurobio.2025.102785
New review on glutathione and its role in astrocytes from lab of GSH guru Ralf Dringen.
doi.org/10.1111/jnc....
doi.org/10.1111/jnc....
Glutathione Metabolism of the Brain—The Role of Astrocytes
Astrocytes supply neurons with the substrates for the synthesis of GSH (γGluCysGly). Astrocytes provide neurons with precursors for the three amino acids that are needed for GSH synthesis. The supply....
doi.org
May 3, 2025 at 5:38 AM
New review on glutathione and its role in astrocytes from lab of GSH guru Ralf Dringen.
doi.org/10.1111/jnc....
doi.org/10.1111/jnc....
Reposted by Caroline (Lindy) Rae
ISN is proud to support #SONA2025 in Marrakech! 🌴
Join us for sessions with Rosa Cossart, Ines Elbini, Elisabeth Ngo Bum, and our ISN Lunch Talk.
Visit the ISN booth to connect, learn more about the society, and grow in neurochemistry.
#WeAreNeurochemistry #neuroskyence #NeuroSky
Join us for sessions with Rosa Cossart, Ines Elbini, Elisabeth Ngo Bum, and our ISN Lunch Talk.
Visit the ISN booth to connect, learn more about the society, and grow in neurochemistry.
#WeAreNeurochemistry #neuroskyence #NeuroSky
April 7, 2025 at 2:38 PM
ISN is proud to support #SONA2025 in Marrakech! 🌴
Join us for sessions with Rosa Cossart, Ines Elbini, Elisabeth Ngo Bum, and our ISN Lunch Talk.
Visit the ISN booth to connect, learn more about the society, and grow in neurochemistry.
#WeAreNeurochemistry #neuroskyence #NeuroSky
Join us for sessions with Rosa Cossart, Ines Elbini, Elisabeth Ngo Bum, and our ISN Lunch Talk.
Visit the ISN booth to connect, learn more about the society, and grow in neurochemistry.
#WeAreNeurochemistry #neuroskyence #NeuroSky
Reposted by Caroline (Lindy) Rae
New Nature Methods paper co-authored by experts from @globalbioimaging.bsky.social highlights the need for sustained investment in open, long-term image data storage.
Read more: doi.org/10.1038/s415...
Read more: doi.org/10.1038/s415...
Enabling global image data sharing in the life sciences - Nature Methods
This Perspective provides a roadmap toward globally federated open data resources for bioimaging data.
doi.org
March 31, 2025 at 1:12 AM
New Nature Methods paper co-authored by experts from @globalbioimaging.bsky.social highlights the need for sustained investment in open, long-term image data storage.
Read more: doi.org/10.1038/s415...
Read more: doi.org/10.1038/s415...
Reposted by Caroline (Lindy) Rae
Job Opportunity at JNC!✍️
The Journal of Neurochemistry is looking for a Freelance Editorial Assistant! If you have a background in science and publishing, this is your chance to join a global research community.
✅ Remote & flexible
✅ Support publishing
✅ Global network
🔗Apply here: bit.ly/3FAs1M6
The Journal of Neurochemistry is looking for a Freelance Editorial Assistant! If you have a background in science and publishing, this is your chance to join a global research community.
✅ Remote & flexible
✅ Support publishing
✅ Global network
🔗Apply here: bit.ly/3FAs1M6
March 18, 2025 at 3:47 PM
Job Opportunity at JNC!✍️
The Journal of Neurochemistry is looking for a Freelance Editorial Assistant! If you have a background in science and publishing, this is your chance to join a global research community.
✅ Remote & flexible
✅ Support publishing
✅ Global network
🔗Apply here: bit.ly/3FAs1M6
The Journal of Neurochemistry is looking for a Freelance Editorial Assistant! If you have a background in science and publishing, this is your chance to join a global research community.
✅ Remote & flexible
✅ Support publishing
✅ Global network
🔗Apply here: bit.ly/3FAs1M6
Reposted by Caroline (Lindy) Rae
📰 ISN News Issue 3 is here! 🧠
📊 @altmetric.com scores - What do they measure?
🏆 Rui Rodrigues(@ruisrodrigues.bsky.social) & Anna Hoffmann share insights on award -winning posters.
📉 What do p-values really tell us?
🔗 ow.ly/NH5L50V3wgs
#WeAreNeurochemistry #neuroskyence #BrainResearch
📊 @altmetric.com scores - What do they measure?
🏆 Rui Rodrigues(@ruisrodrigues.bsky.social) & Anna Hoffmann share insights on award -winning posters.
📉 What do p-values really tell us?
🔗 ow.ly/NH5L50V3wgs
#WeAreNeurochemistry #neuroskyence #BrainResearch
February 21, 2025 at 12:26 PM
📰 ISN News Issue 3 is here! 🧠
📊 @altmetric.com scores - What do they measure?
🏆 Rui Rodrigues(@ruisrodrigues.bsky.social) & Anna Hoffmann share insights on award -winning posters.
📉 What do p-values really tell us?
🔗 ow.ly/NH5L50V3wgs
#WeAreNeurochemistry #neuroskyence #BrainResearch
📊 @altmetric.com scores - What do they measure?
🏆 Rui Rodrigues(@ruisrodrigues.bsky.social) & Anna Hoffmann share insights on award -winning posters.
📉 What do p-values really tell us?
🔗 ow.ly/NH5L50V3wgs
#WeAreNeurochemistry #neuroskyence #BrainResearch
Happy to have helped (skyless) Alistair Carroll publish the first paper from his PhD research. There’s more to come!
New publication with our collaborators @blackdoginst.bsky.social showing the difference in transcranial direct current brain stimulation caused by brain sutures (joints in skull bones).
doi.org/10.1097/YCT....
Thanks to @nifaustralia.bsky.social
doi.org/10.1097/YCT....
Thanks to @nifaustralia.bsky.social
December 11, 2024 at 7:33 PM
Happy to have helped (skyless) Alistair Carroll publish the first paper from his PhD research. There’s more to come!
Reposted by Caroline (Lindy) Rae
Interested in how maternal stress affects the offspring’s brain? Come and do a PhD with us in beautiful Edinburgh. More info here: www.findaphd.com/phds/project...
a drawing of a brain with a rainbow and a blue one
ALT: a drawing of a brain with a rainbow and a blue one
media.tenor.com
December 9, 2024 at 2:12 PM
Interested in how maternal stress affects the offspring’s brain? Come and do a PhD with us in beautiful Edinburgh. More info here: www.findaphd.com/phds/project...
Interesting. Seems to need relatively high levels of R-BHB.
New paper shows ketones regulate proteostasis. As stated in the paper, “Ketone bodies are janitors of damaged proteins, chaperoning away molecular waste so organisms can operate at peak molecular fitness.”
www.cell.com/cell-chemica...
www.cell.com/cell-chemica...
β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain
Madhavan et al. identify and characterize the selective regulation of protein solubility by the ketone body β-hydroxybutyrate (βHB) across a range of models. βHB exposure rescues cell-based and C. elegans models of amyloid-β proteotoxicity, and induces clearance of neurodegeneration-related proteins from aged mouse brain following exogenous ketone supplementation.
www.cell.com
December 6, 2024 at 7:48 AM
Interesting. Seems to need relatively high levels of R-BHB.
Time to (re)join for all neurochemists!👇👇👇👇👇👇
🌟 ISN Membership 2025 is Open!
Join or renew today to unlock:
✅ Discounted ISN meeting registration fees
✅ Access to grants & awards
✅ Free online access to JNC
✅ Discounted JNC open access fees
Be part of the global neurochemistry community 👉 ow.ly/jf1250UjGWA
#WeAreNeurochemistry #neuroskyence
Join or renew today to unlock:
✅ Discounted ISN meeting registration fees
✅ Access to grants & awards
✅ Free online access to JNC
✅ Discounted JNC open access fees
Be part of the global neurochemistry community 👉 ow.ly/jf1250UjGWA
#WeAreNeurochemistry #neuroskyence
December 5, 2024 at 9:52 AM
Time to (re)join for all neurochemists!👇👇👇👇👇👇
Can verify that it is lovely. I gave one to an astrocyte aficionado but it was hard parting with it….
November 22, 2024 at 7:57 PM
Can verify that it is lovely. I gave one to an astrocyte aficionado but it was hard parting with it….
Just published a little paper about the role of L-Proline in brain metabolism. It stimulates mitochondrial metabolism but doesn't seem to do it by being metabolised (under the conditions studied). Yet another unsolved mystery in brain energy metabolism... Scratches head....
doi.org/10.1007/s110...
doi.org/10.1007/s110...
l-Proline Alters Energy Metabolism in Brain Cortical Tissue Slices - Neurochemical Research
L-Proline (l-Pro) is a non-essential amino acid which, in high concentrations, can cause neurological problems including seizures, although the causative mechanism for this is unclear. Here, we studie...
doi.org
November 18, 2024 at 10:05 PM
Just published a little paper about the role of L-Proline in brain metabolism. It stimulates mitochondrial metabolism but doesn't seem to do it by being metabolised (under the conditions studied). Yet another unsolved mystery in brain energy metabolism... Scratches head....
doi.org/10.1007/s110...
doi.org/10.1007/s110...
Thanks for underlining this really important support initiative @zilamartinezlozada.bsky.social
The ISN www.neurochemistry.org has support for carers sewn into its grant and travel schemes + special support for travel to the biennial meeting.
Next one is in fantastic New York city in 2025.
The ISN www.neurochemistry.org has support for carers sewn into its grant and travel schemes + special support for travel to the biennial meeting.
Next one is in fantastic New York city in 2025.
November 18, 2024 at 9:32 PM
Thanks for underlining this really important support initiative @zilamartinezlozada.bsky.social
The ISN www.neurochemistry.org has support for carers sewn into its grant and travel schemes + special support for travel to the biennial meeting.
Next one is in fantastic New York city in 2025.
The ISN www.neurochemistry.org has support for carers sewn into its grant and travel schemes + special support for travel to the biennial meeting.
Next one is in fantastic New York city in 2025.
Sodium dysregulation may play a role in Alzheimer's disease with links to increased amyloid-dependent tau pathology, neurodegeneration, and cognitive impairment. Sodium channel subunits (SCN2B &3B) showed strongest correlation with hippocampal volume and cognitive function
doi.org/10.1111/jnc....
doi.org/10.1111/jnc....
November 15, 2024 at 11:31 AM
Sodium dysregulation may play a role in Alzheimer's disease with links to increased amyloid-dependent tau pathology, neurodegeneration, and cognitive impairment. Sodium channel subunits (SCN2B &3B) showed strongest correlation with hippocampal volume and cognitive function
doi.org/10.1111/jnc....
doi.org/10.1111/jnc....
Latest issue of ISN News is out and available to read online. Includes advice on responding to reviewers from @drbreaky.bsky.social
www.neurochemistry.org/isn-news-02/
www.neurochemistry.org/isn-news-02/
November 15, 2024 at 11:46 AM
Latest issue of ISN News is out and available to read online. Includes advice on responding to reviewers from @drbreaky.bsky.social
www.neurochemistry.org/isn-news-02/
www.neurochemistry.org/isn-news-02/