Brigette D. Manohar
@bmanohar.bsky.social
@fiubiomed ‘20 | @berkeleymcb PhD candidate @ the Wilson Lab, IGI 🧫| working on novel CRISPR based therapeutics for PD & non-viral delivery to the brain
Reposted by Brigette D. Manohar
Non-viral delivery of CRISPR components to the brain using peptide-enabled ribonucleoproteins
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Efficient in vivo mammalian neuron editing using peptide-mediated CRISPR enzyme delivery
CRISPR-mediated genome editing of the central nervous system (CNS) has the potential to revolutionize the treatment of neurological disorders, including neurodegenerative disorders such as Huntington’...
www.biorxiv.org
December 15, 2025 at 10:20 PM
Non-viral delivery of CRISPR components to the brain using peptide-enabled ribonucleoproteins
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Honored that this work represents my first "first-author" preprint of my PhD journey at
@berkeleymcb.bsky.social. Grateful for the incredible mentorship and collaborations. Neuro-PERC was a true multi-institution effort. Read the thread for the details!
@berkeleymcb.bsky.social. Grateful for the incredible mentorship and collaborations. Neuro-PERC was a true multi-institution effort. Read the thread for the details!
Big news! Our team developed Neuro-PERC, a non-viral CRISPR delivery platform for genome editing of the brain. In our new preprint - bit.ly/NeuroPERC_pre - we report efficient editing in multiple models & species, including field-first results in large animals (pigs) 🧵👇
bit.ly
December 2, 2025 at 7:05 PM
Honored that this work represents my first "first-author" preprint of my PhD journey at
@berkeleymcb.bsky.social. Grateful for the incredible mentorship and collaborations. Neuro-PERC was a true multi-institution effort. Read the thread for the details!
@berkeleymcb.bsky.social. Grateful for the incredible mentorship and collaborations. Neuro-PERC was a true multi-institution effort. Read the thread for the details!
Reposted by Brigette D. Manohar
Huge credit to @bmanohar.bsky.social for leading this collaborative effort, based at @innovativegenomics.bsky.social & @berkeleymcb.bsky.social, with major contributions from OSU's Krys Bankiewicz & Russ Lonser, as well as crucial support from NIH's SCGE consortium @scge.bsky.social
December 2, 2025 at 9:11 AM
Huge credit to @bmanohar.bsky.social for leading this collaborative effort, based at @innovativegenomics.bsky.social & @berkeleymcb.bsky.social, with major contributions from OSU's Krys Bankiewicz & Russ Lonser, as well as crucial support from NIH's SCGE consortium @scge.bsky.social
Reposted by Brigette D. Manohar
Efficient in vivo mammalian neuron editing using peptide-mediated CRISPR enzyme delivery https://www.biorxiv.org/content/10.1101/2025.11.26.690638v1
November 30, 2025 at 1:15 AM
Efficient in vivo mammalian neuron editing using peptide-mediated CRISPR enzyme delivery https://www.biorxiv.org/content/10.1101/2025.11.26.690638v1
Sweater weather ☃️❄️
December 2, 2025 at 2:40 AM
Sweater weather ☃️❄️
Reposted by Brigette D. Manohar
Newly discovered fossils tie this foot to a primitive human relative known as Australopithecus deyiremeda, an enigmatic contemporary of A. afarensis, whose species included the famed Lucy skeleton. https://scim.ag/4414MEj
A puzzling, 3.4-million-year-old fossil foot belonged to a contemporary of the famed Lucy
Identity of the toe bones and other fossils could shake up the human family tree
scim.ag
December 1, 2025 at 11:30 PM
Newly discovered fossils tie this foot to a primitive human relative known as Australopithecus deyiremeda, an enigmatic contemporary of A. afarensis, whose species included the famed Lucy skeleton. https://scim.ag/4414MEj
Reposted by Brigette D. Manohar
For the second year in a row, IGI had a booth at #NDiSTEM, the annual conference from SACNAS! More than a hundred students stopped by to learn about IGI and opportunities at the University of California.
November 26, 2025 at 4:02 PM
For the second year in a row, IGI had a booth at #NDiSTEM, the annual conference from SACNAS! More than a hundred students stopped by to learn about IGI and opportunities at the University of California.