regarding the risks and benefits of treatments/interventions. Failing to appreciate the significant, far reaching, neurocognitive impact of depressive illnesses can lead to settling for partial or inadequate treatment responses.

In clinical practice, the results of this study align with what we see: Psychiatric illnesses, especially depressive illness, can have significant effects on cognitive functioning, and adequate appreciation of this reality allows both patients and providers to engage in a more nuanced discussion

Without delving into the greater question of BL vs RUL, this study underscores the importance of the primary goal of treatment - to induce remission of depressive symptoms, and points to the fact that adequate treatment of depressive symptoms will be a central factor in cognitive outcomes.

There is a constant effort, on the treating psychiatrist, to reduce the risk of adverse cognitive outcomes, which often manifests in the preferential selection of unilateral and ultra-brief pulse.

2) technical parameters re: ECT treatment were not independently associated with adverse cognitive outcomes.

The second point is what is most important, in my mind. We are limited by our study durations re: differences in cognitive outcomes with varying electrode placement, etc.