blbriefpulse.bsky.social
@blbriefpulse.bsky.social
#Internist, #Psychiatrist, struggling writer of a pithy bio. Views are my own and not medical advice.
Reposted
Hot off the press! We found that electroconvulsive therapy (ECT) induces a previously undescribed, second brain event after seizure, called cortical spreading depolarization (CSD), using optical neuroimaging in both a mouse model to human patients. 🧵 below!

doi.org/10.1038/s414...
Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans - Nature Communications
The underlying mechanism of electroconvulsive therapy remains not fully understood. Here, the authors use optical neuroimaging in mice and humans to show that electroconvulsive therapy elicits a secon...
doi.org
May 18, 2025 at 6:03 PM
I don’t know if Charlie Kellner has a BlueSky, but if you don’t follow his ECT Blog, you should!

He finds interesting articles and includes his own commentary on the value of the paper:

ectpsych.blogspot.com/2025/02/use-...
Use of ECT in Adolescents in Singapore: New Data in JECT
Ouit on PubMed, from investigators in Singapore, is this study: Use of Electroconvulsive Therapy Treatment in Adolescents in Singapore. Che...
ectpsych.blogspot.com
March 3, 2025 at 11:26 PM
Mystery Medicine Monday (best I could come up with):
Propylene glycol toxicity always comes up as a concern with high dose parenteral Ativan, has anyone experienced this in clinical practice? I have given large doses of Ativan and have yet to encounter a case.
March 3, 2025 at 11:23 PM
www.sciencedirect.com/science/arti...

This is an important and excellent study on one of the major concerns with ECT in regards to cognitive outcomes. It sheds light on a few important points: 1) persistent depressive symptoms are deleterious to cognitive function and 2)
Who is at risk of long-term subjective memory impairment after electroconvulsive therapy?
Electroconvulsive therapy (ECT) is an effective treatment for depression with potential transient cognitive side effects. However, subjective memory i…
www.sciencedirect.com
December 28, 2024 at 1:08 PM