Blaise Mariner, PhD
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blaisemariner.bsky.social
Blaise Mariner, PhD
@blaisemariner.bsky.social
blaisemariner.com

Postdoc with http://smack-lab.com | PhD with https://labmccormick.org
Pinned
Kicking-off my bluesky posts with a @dogagingproject.bsky.social preprint from my first year doing postdoctoral work at Arizona State! Onto peer-review!

www.biorxiv.org/content/10.1...

... and this is only the beginning! :D

#forksup ☀️ 😈 🔱
DNA methylation of transposons pattern aging differences across a diverse cohort of dogs from the Dog Aging Project
Within a species, larger individuals often have shorter lives and higher rates of age-related disease. Despite this well-known link, we still know little about underlying age-related epigenetic differ...
www.biorxiv.org
Great to see drugs I studied during my PhD are extending lifespan in mice!

doi.org/10.1007/s113...

My PhD advisor Dr McCormick has made great progress understanding the basic biology that these drugs impact, mostly unpublished, but it’s well on its way!
For now:
doi.org/10.1007/s113...
November 13, 2025 at 9:34 PM
Asking for qPCR confirmation of RNA-seq is worse than asking an engineer to re-measure a laser scan with a tape measure
October 30, 2025 at 3:54 PM
Many autosomal genes are expressed from only one allele or show consistent bias toward one.

How cells establish and maintain these allele-specific patterns remains a mystery — yet this choice may be a key determinant of lifespan or disease

Check it:
Mariner et al. doi.org/10.1101/2025.10.14.682127
October 27, 2025 at 4:31 PM
There are a lot of aging studies, especially recently, about the mutation accumulation hypothesis. Hydra wants to contribute to the discussion, too.

Hydra has mammal-like mutation rates facilitating fast adaptation despite its nonaging phenotype. doi: 10.1101/gr.279025.124
October 15, 2025 at 7:42 PM
Reposted by Blaise Mariner, PhD
Genomics pioneer George Church earns first retraction for anti-aging gene therapy paper

@averyorrall.bsky.social reports
Genomics pioneer George Church earns first retraction for anti-aging gene therapy paper
George Church A paper coauthored by geneticist George Church has been retracted following an internal review at a university where several coauthors are based. The article appeared in the Proceedin…
retractionwatch.com
August 13, 2025 at 9:22 PM
Reposted by Blaise Mariner, PhD
📣 Meet Dr. Noah Snyder-Mackler, expert in how social & environmental factors shape molecular aging. Don’t miss his talk at #AGEAnnualMeeting2025: “Environmental Modifiers of Molecular Aging.” 🗓️ May 12 | 🕝 8:30 AM | 📍 AnchorAGE, AK
🔗 Register: bit.ly/4cJx8Gd

#Geroscience #HealthyAging #Epigenetics
April 23, 2025 at 2:13 PM
Reposted by Blaise Mariner, PhD
🔥New Night Science paper!!
Discovery happens when your initial plans fall apart but it requires you to have a particular mindset: it's not extraverted, orderly, neurotic or agreeable that's the most important – discovery requires an OPENNESS to new ideas and unexpected insights.
April 2, 2025 at 11:28 AM
Just locked in my spot at AnchorAGE May 11 - 14 📅

Ready to dive into aging science and gather insights!

I hope to see you there!
🌟 Join us in Anchorage, Alaska for the AGE 53rd Annual Meeting: New Frontiers in Aging Research! 🌟

This is an event you won’t want to miss!

📅 Save the Date & Be Part of the Conversation!
March 11, 2025 at 11:00 PM
Reposted by Blaise Mariner, PhD
#StandUpForScience2025! Our greatest and most useful minds, get loud. If you support the opposition, it’s because you chose harming people over helping them. You’re either a part of the problem or a part of the solution. #science #Politics #activism #protest #DoNoHarm #scientificmethod #scientists
WATCH LIVE: 'Stand up for Science' rally with Bill Nye and others at Lincoln Memorial in Washington
YouTube video by PBS NewsHour
www.youtube.com
March 7, 2025 at 6:19 PM
Prompt: "Explain _____ to me like I am 5 years old."

ChatGPT: "So, imagine you have a big box of crayons...."

LMAO

Well done, chat. Well done 👏👏👏
March 7, 2025 at 6:41 PM
Reposted by Blaise Mariner, PhD
Good papers lead to more questions than they answer. That's because (as Blaise Pascal wrote) knowledge is like a sphere: the larger it gets the larger also its surface, which is its interface with the unknown.
January 2, 2025 at 11:23 PM
Reposted by Blaise Mariner, PhD
Thanks to Bloomberg TV Wall Street Week, David Westin, Sam Hornblower for a superb look at the troubling state of play in Alzheimer's research, featuring my new book "Doctored" and insights by Matthew Schrag and @elisabethbik.bsky.social at 10:30 on clip www.youtube.com/watch?v=DM4s...
Tariffs, the Future of Cancer and Alzheimer's, Global Debt Cycles | Wall Street Week
YouTube video by Bloomberg Television
www.youtube.com
February 8, 2025 at 12:59 AM
Reposted by Blaise Mariner, PhD
Postdoc position available: Work with us at @mblscience.bsky.social on maternal age effects, #transgenerational inheritance, and #mitochondria. Cool project with a great model system. Postdoc salary at the MBL is well above the NIH pay scale!
#GeroSky #aging

recruiting.ultipro.com/MAR1033MBL/J...
recruiting.ultipro.com
December 6, 2024 at 9:39 PM
Reposted by Blaise Mariner, PhD
🌟 Join us in Anchorage, Alaska for the AGE 53rd Annual Meeting: New Frontiers in Aging Research! 🌟

This is an event you won’t want to miss!

📅 Save the Date & Be Part of the Conversation!
January 30, 2025 at 7:26 PM
Kicking-off my bluesky posts with a @dogagingproject.bsky.social preprint from my first year doing postdoctoral work at Arizona State! Onto peer-review!

www.biorxiv.org/content/10.1...

... and this is only the beginning! :D

#forksup ☀️ 😈 🔱
DNA methylation of transposons pattern aging differences across a diverse cohort of dogs from the Dog Aging Project
Within a species, larger individuals often have shorter lives and higher rates of age-related disease. Despite this well-known link, we still know little about underlying age-related epigenetic differ...
www.biorxiv.org
December 2, 2024 at 1:58 PM