Ever wonder how to figure out a molecule’s formula just from its mass?
In today’s edition of Bioanalytical Bees, I break down how to ID compounds from scratch - no library, no MS2, just some mass spec magic.

bioanalytics.substack.com/p/identifyin...

#metabolomics #lcms

Important MOB talk coming up: A tutorial on depositing data to Metabolomics Workbench. I’ll admit: I only do it when a journal requires it, and I don’t usually go the extra mile with metadata. Hoping this seminar changes my ways!

(Also, there’s free food 😊)
www.moboston.com/about

#metabolomics

Need a reference database for metabolite profiling? Training an ML model on chemical structures? Pubchem is the world’s largest chemical database, @pola.rs streaming engine lets you wrangle it on your laptop.

bioanalytics.substack.com/p/processing...
#cheminformatics #bioinformatics #Chemsky

What are internal standards and how exactly do we use them to correct for experimental hiccups? Shedding light on this important application of labelled metabolites.

bioanalytics.substack.com/p/what-are-i...

In untargeted (metabol)omics, we don’t know what we’re looking for, so how do we optimize separation while maximizing metabolite coverage?

Check out this post for some practical chromatography tips I wish I’d known earlier: bioanalytics.substack.com/p/optimizing...

#metabolomics #lcms

Our paper showing that ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST is now published @cp-cellmetabolism.bsky.social

Thanks to everyone involved!

www.cell.com/cell-metabol...

A little late to Blusky but first things first: Join us at Metabolomics of Boston if you work on small molecule mass spectrometry! Come for the talks, stay for the people (& snacks, but maybe that's just me)