Thank you again, Andrew ;)

🧩 Our system can selectively recognize 3WJs in two ways:
1️⃣ From preformed Co(II) helicates
2️⃣ Or directly from the P-agg supramolecular polymer — just by adding Co(II) ions!

💤 The polymer acts as a latent reservoir, releasing bioactive helicates on demand.

#DNAjunction #SupramolecularChem #ChemSky

🔍 Both Co(II) and Co(III) peptide helicates selectively recognize three-way DNA junctions (3WJs) — a key non-canonical DNA structure 🧬
🧪 Competition assays confirm their strong preference for 3WJs over canonical B-DNA

#DNAjunction #SupramolecularChem #ChemSky

Redox chiral control 🌀
👉 Oxidizing ΛΛ-Co(II) helicate to Co(III) in water keeps the ΛΛ chirality
👉 But in DMSO… ΛΛ helicate flips into its ΔΔ form!
💡 Metal oxidation enables chiral inversion — a novel powerful tool to build redox-responsive chiral systems

#DNAjunction #SupramolecularChem #ChemSky

After adding Co(II) ions → magic happens ✨
👉 In water, P-agg slowly disassembles and BTMA-1 folds into ΛΛ helicates
👉 In DMSO, molecularly dissolved BTMA-1 folds into ΔΔ helicates
👉 This chiral change is fully reversible and driven by arginine side chains

#DNAjunction #SupramolecularChem #ChemSky

What happens to BTMA-1 in water?
👉 It self-assembles into P-agg: a chiral supramolecular helical polymer.
👉 P-agg is stabilized by π–π stacking and H-bonding.
👉 In this “off” state, P-agg acts as an inert reservoir — no DNA binding yet!

#DNAjunction #SupramolecularChem #ChemSky

Exactly! They always save the day 😄🌀

The key to our approach is BTMA-1…
👉 A C₃-symmetric peptide equipped with six 2,2’-bipyridine arms.
👉 Designed to form chiral supramolecular helical polymers in water.
👉 And to generate discrete peptide helicates upon metal ion coordination.

#DNAjunction #SupramolecularChem #ChemSky

Great talk and a real pleasure to meet you again, Ingo. Best :)

Thank you for your great work leading AEBIN all these years, Patrick 👏