Vázquez López Lab
@biometalusc.bsky.social
Research group of Miguel Vázquez López. Full Professor of Inorganic Chemistry at Universidade de Santiago de Compostela and PI at CiQUS (Spain). Supramolecular Chemistry & Chemical Biology 🇪🇺
http://www.usc.es/ciqus/en/groups/biometal
http://www.usc.es/ciqus/en/groups/biometal
The 3WJ nuclease team 💪 @akellett.bsky.social @pepman.bsky.social @ciqus.bsky.social @dublincityuni.bsky.social @usc.gal #ChemSky #DNAjunctions
October 27, 2025 at 10:15 AM
The 3WJ nuclease team 💪 @akellett.bsky.social @pepman.bsky.social @ciqus.bsky.social @dublincityuni.bsky.social @usc.gal #ChemSky #DNAjunctions
We had the pleasure of hosting @akellett.bsky.social (@dublincityuni.bsky.social) at @ciqus.bsky.social for a great lecture on his latest advances in metallodrugs and artificial gene editing.
An inspiring visit that strengthens our scientific collaboration and friendship. #Metallodrugs #ChemSky
An inspiring visit that strengthens our scientific collaboration and friendship. #Metallodrugs #ChemSky
October 27, 2025 at 10:10 AM
We had the pleasure of hosting @akellett.bsky.social (@dublincityuni.bsky.social) at @ciqus.bsky.social for a great lecture on his latest advances in metallodrugs and artificial gene editing.
An inspiring visit that strengthens our scientific collaboration and friendship. #Metallodrugs #ChemSky
An inspiring visit that strengthens our scientific collaboration and friendship. #Metallodrugs #ChemSky
We’re excited to host Prof. Andrew Kellett (DCU) @akellett.bsky.social next Friday 24th at @ciqus.bsky.social (11:00 a.m.) for a talk on “Recent Advances in Artificial Gene Editing and DNA-Targeted Metallodrug Design”
#ChemBio #ChemSky #DNA #Metallodrugs
#ChemBio #ChemSky #DNA #Metallodrugs
October 14, 2025 at 11:43 AM
We’re excited to host Prof. Andrew Kellett (DCU) @akellett.bsky.social next Friday 24th at @ciqus.bsky.social (11:00 a.m.) for a talk on “Recent Advances in Artificial Gene Editing and DNA-Targeted Metallodrug Design”
#ChemBio #ChemSky #DNA #Metallodrugs
#ChemBio #ChemSky #DNA #Metallodrugs
🎨 Our JACS Supplementary Cover is out!
A supramolecular story of fibers, peptide helicates, and DNA three-way junctions…
👉 pubs.acs.org/toc/jacsat/1...
#DNAjunction #MyACSCover #ChemSky #SupramolecularChem
@acs.org @pubs.acs.org @jacs.acspublications.org
A supramolecular story of fibers, peptide helicates, and DNA three-way junctions…
👉 pubs.acs.org/toc/jacsat/1...
#DNAjunction #MyACSCover #ChemSky #SupramolecularChem
@acs.org @pubs.acs.org @jacs.acspublications.org
July 23, 2025 at 9:40 AM
🎨 Our JACS Supplementary Cover is out!
A supramolecular story of fibers, peptide helicates, and DNA three-way junctions…
👉 pubs.acs.org/toc/jacsat/1...
#DNAjunction #MyACSCover #ChemSky #SupramolecularChem
@acs.org @pubs.acs.org @jacs.acspublications.org
A supramolecular story of fibers, peptide helicates, and DNA three-way junctions…
👉 pubs.acs.org/toc/jacsat/1...
#DNAjunction #MyACSCover #ChemSky #SupramolecularChem
@acs.org @pubs.acs.org @jacs.acspublications.org
🧩 Our system can selectively recognize 3WJs in two ways:
1️⃣ From preformed Co(II) helicates
2️⃣ Or directly from the P-agg supramolecular polymer — just by adding Co(II) ions!
💤 The polymer acts as a latent reservoir, releasing bioactive helicates on demand.
#DNAjunction #SupramolecularChem #ChemSky
1️⃣ From preformed Co(II) helicates
2️⃣ Or directly from the P-agg supramolecular polymer — just by adding Co(II) ions!
💤 The polymer acts as a latent reservoir, releasing bioactive helicates on demand.
#DNAjunction #SupramolecularChem #ChemSky
June 17, 2025 at 10:15 AM
🧩 Our system can selectively recognize 3WJs in two ways:
1️⃣ From preformed Co(II) helicates
2️⃣ Or directly from the P-agg supramolecular polymer — just by adding Co(II) ions!
💤 The polymer acts as a latent reservoir, releasing bioactive helicates on demand.
#DNAjunction #SupramolecularChem #ChemSky
1️⃣ From preformed Co(II) helicates
2️⃣ Or directly from the P-agg supramolecular polymer — just by adding Co(II) ions!
💤 The polymer acts as a latent reservoir, releasing bioactive helicates on demand.
#DNAjunction #SupramolecularChem #ChemSky
🔍 Both Co(II) and Co(III) peptide helicates selectively recognize three-way DNA junctions (3WJs) — a key non-canonical DNA structure 🧬
🧪 Competition assays confirm their strong preference for 3WJs over canonical B-DNA
#DNAjunction #SupramolecularChem #ChemSky
🧪 Competition assays confirm their strong preference for 3WJs over canonical B-DNA
#DNAjunction #SupramolecularChem #ChemSky
June 16, 2025 at 6:42 AM
🔍 Both Co(II) and Co(III) peptide helicates selectively recognize three-way DNA junctions (3WJs) — a key non-canonical DNA structure 🧬
🧪 Competition assays confirm their strong preference for 3WJs over canonical B-DNA
#DNAjunction #SupramolecularChem #ChemSky
🧪 Competition assays confirm their strong preference for 3WJs over canonical B-DNA
#DNAjunction #SupramolecularChem #ChemSky
Redox chiral control 🌀
👉 Oxidizing ΛΛ-Co(II) helicate to Co(III) in water keeps the ΛΛ chirality
👉 But in DMSO… ΛΛ helicate flips into its ΔΔ form!
💡 Metal oxidation enables chiral inversion — a novel powerful tool to build redox-responsive chiral systems
#DNAjunction #SupramolecularChem #ChemSky
👉 Oxidizing ΛΛ-Co(II) helicate to Co(III) in water keeps the ΛΛ chirality
👉 But in DMSO… ΛΛ helicate flips into its ΔΔ form!
💡 Metal oxidation enables chiral inversion — a novel powerful tool to build redox-responsive chiral systems
#DNAjunction #SupramolecularChem #ChemSky
June 15, 2025 at 5:22 AM
Redox chiral control 🌀
👉 Oxidizing ΛΛ-Co(II) helicate to Co(III) in water keeps the ΛΛ chirality
👉 But in DMSO… ΛΛ helicate flips into its ΔΔ form!
💡 Metal oxidation enables chiral inversion — a novel powerful tool to build redox-responsive chiral systems
#DNAjunction #SupramolecularChem #ChemSky
👉 Oxidizing ΛΛ-Co(II) helicate to Co(III) in water keeps the ΛΛ chirality
👉 But in DMSO… ΛΛ helicate flips into its ΔΔ form!
💡 Metal oxidation enables chiral inversion — a novel powerful tool to build redox-responsive chiral systems
#DNAjunction #SupramolecularChem #ChemSky
After adding Co(II) ions → magic happens ✨
👉 In water, P-agg slowly disassembles and BTMA-1 folds into ΛΛ helicates
👉 In DMSO, molecularly dissolved BTMA-1 folds into ΔΔ helicates
👉 This chiral change is fully reversible and driven by arginine side chains
#DNAjunction #SupramolecularChem #ChemSky
👉 In water, P-agg slowly disassembles and BTMA-1 folds into ΛΛ helicates
👉 In DMSO, molecularly dissolved BTMA-1 folds into ΔΔ helicates
👉 This chiral change is fully reversible and driven by arginine side chains
#DNAjunction #SupramolecularChem #ChemSky
June 14, 2025 at 6:01 AM
After adding Co(II) ions → magic happens ✨
👉 In water, P-agg slowly disassembles and BTMA-1 folds into ΛΛ helicates
👉 In DMSO, molecularly dissolved BTMA-1 folds into ΔΔ helicates
👉 This chiral change is fully reversible and driven by arginine side chains
#DNAjunction #SupramolecularChem #ChemSky
👉 In water, P-agg slowly disassembles and BTMA-1 folds into ΛΛ helicates
👉 In DMSO, molecularly dissolved BTMA-1 folds into ΔΔ helicates
👉 This chiral change is fully reversible and driven by arginine side chains
#DNAjunction #SupramolecularChem #ChemSky
What happens to BTMA-1 in water?
👉 It self-assembles into P-agg: a chiral supramolecular helical polymer.
👉 P-agg is stabilized by π–π stacking and H-bonding.
👉 In this “off” state, P-agg acts as an inert reservoir — no DNA binding yet!
#DNAjunction #SupramolecularChem #ChemSky
👉 It self-assembles into P-agg: a chiral supramolecular helical polymer.
👉 P-agg is stabilized by π–π stacking and H-bonding.
👉 In this “off” state, P-agg acts as an inert reservoir — no DNA binding yet!
#DNAjunction #SupramolecularChem #ChemSky
June 13, 2025 at 7:18 AM
What happens to BTMA-1 in water?
👉 It self-assembles into P-agg: a chiral supramolecular helical polymer.
👉 P-agg is stabilized by π–π stacking and H-bonding.
👉 In this “off” state, P-agg acts as an inert reservoir — no DNA binding yet!
#DNAjunction #SupramolecularChem #ChemSky
👉 It self-assembles into P-agg: a chiral supramolecular helical polymer.
👉 P-agg is stabilized by π–π stacking and H-bonding.
👉 In this “off” state, P-agg acts as an inert reservoir — no DNA binding yet!
#DNAjunction #SupramolecularChem #ChemSky
The key to our approach is BTMA-1…
👉 A C₃-symmetric peptide equipped with six 2,2’-bipyridine arms.
👉 Designed to form chiral supramolecular helical polymers in water.
👉 And to generate discrete peptide helicates upon metal ion coordination.
#DNAjunction #SupramolecularChem #ChemSky
👉 A C₃-symmetric peptide equipped with six 2,2’-bipyridine arms.
👉 Designed to form chiral supramolecular helical polymers in water.
👉 And to generate discrete peptide helicates upon metal ion coordination.
#DNAjunction #SupramolecularChem #ChemSky
June 12, 2025 at 8:00 AM
The key to our approach is BTMA-1…
👉 A C₃-symmetric peptide equipped with six 2,2’-bipyridine arms.
👉 Designed to form chiral supramolecular helical polymers in water.
👉 And to generate discrete peptide helicates upon metal ion coordination.
#DNAjunction #SupramolecularChem #ChemSky
👉 A C₃-symmetric peptide equipped with six 2,2’-bipyridine arms.
👉 Designed to form chiral supramolecular helical polymers in water.
👉 And to generate discrete peptide helicates upon metal ion coordination.
#DNAjunction #SupramolecularChem #ChemSky
🎉 Honored to share that I’ve been appointed as a new board member of @aebin25.bsky.social at #BioCiudadReal25.
Grateful for the trust and excited to contribute to the growth of our vibrant community of spanish bioinorganic chemists.
#AEBIN #BioinorgChem #ChemSky
Grateful for the trust and excited to contribute to the growth of our vibrant community of spanish bioinorganic chemists.
#AEBIN #BioinorgChem #ChemSky
June 4, 2025 at 7:45 AM
🎉 Honored to share that I’ve been appointed as a new board member of @aebin25.bsky.social at #BioCiudadReal25.
Grateful for the trust and excited to contribute to the growth of our vibrant community of spanish bioinorganic chemists.
#AEBIN #BioinorgChem #ChemSky
Grateful for the trust and excited to contribute to the growth of our vibrant community of spanish bioinorganic chemists.
#AEBIN #BioinorgChem #ChemSky
Something big is coming…
Soon, we’ll be able to share a story of peptide helicates, helical polymers, and DNA junctions.
Stay tuned 😉
#ChemSky #DNAJunctions #SupraChemSky #ChemBioSky
Soon, we’ll be able to share a story of peptide helicates, helical polymers, and DNA junctions.
Stay tuned 😉
#ChemSky #DNAJunctions #SupraChemSky #ChemBioSky
May 28, 2025 at 6:07 AM
Something big is coming…
Soon, we’ll be able to share a story of peptide helicates, helical polymers, and DNA junctions.
Stay tuned 😉
#ChemSky #DNAJunctions #SupraChemSky #ChemBioSky
Soon, we’ll be able to share a story of peptide helicates, helical polymers, and DNA junctions.
Stay tuned 😉
#ChemSky #DNAJunctions #SupraChemSky #ChemBioSky
Call for Expressions of Interest – MSCA Postdocs 2025
Join my group at CiQUS to work on “Selective DNA Junction Binders for Targeted Anticancer Therapy”.
Deadline: June 15
www.usc.es/ciqus/en/MSC...
#MSCA #CiQUS #DNAJunctions #Postdoc #ChemSky #ChemBioSky
Join my group at CiQUS to work on “Selective DNA Junction Binders for Targeted Anticancer Therapy”.
Deadline: June 15
www.usc.es/ciqus/en/MSC...
#MSCA #CiQUS #DNAJunctions #Postdoc #ChemSky #ChemBioSky
May 26, 2025 at 12:03 PM
Call for Expressions of Interest – MSCA Postdocs 2025
Join my group at CiQUS to work on “Selective DNA Junction Binders for Targeted Anticancer Therapy”.
Deadline: June 15
www.usc.es/ciqus/en/MSC...
#MSCA #CiQUS #DNAJunctions #Postdoc #ChemSky #ChemBioSky
Join my group at CiQUS to work on “Selective DNA Junction Binders for Targeted Anticancer Therapy”.
Deadline: June 15
www.usc.es/ciqus/en/MSC...
#MSCA #CiQUS #DNAJunctions #Postdoc #ChemSky #ChemBioSky
Can’t wait to travel to Pavia next month to see my friends.
Honored to speak at the Università di Pavia about our latest work on peptide helicates and DNA three-way junctions.
#DNAJunctions #ChemSky #ChemBioSky
Honored to speak at the Università di Pavia about our latest work on peptide helicates and DNA three-way junctions.
#DNAJunctions #ChemSky #ChemBioSky
May 23, 2025 at 1:30 PM
Can’t wait to travel to Pavia next month to see my friends.
Honored to speak at the Università di Pavia about our latest work on peptide helicates and DNA three-way junctions.
#DNAJunctions #ChemSky #ChemBioSky
Honored to speak at the Università di Pavia about our latest work on peptide helicates and DNA three-way junctions.
#DNAJunctions #ChemSky #ChemBioSky
A small gift for @christinecardin.bsky.social — a short video of the beautiful crystal she solved with Mark Searcey
A bright fragment of science 🧬 onlinelibrary.wiley.com/doi/10.1002/...
#IRN_NAC #ChemSky #DNAJunctions
A bright fragment of science 🧬 onlinelibrary.wiley.com/doi/10.1002/...
#IRN_NAC #ChemSky #DNAJunctions
May 19, 2025 at 12:28 PM
A small gift for @christinecardin.bsky.social — a short video of the beautiful crystal she solved with Mark Searcey
A bright fragment of science 🧬 onlinelibrary.wiley.com/doi/10.1002/...
#IRN_NAC #ChemSky #DNAJunctions
A bright fragment of science 🧬 onlinelibrary.wiley.com/doi/10.1002/...
#IRN_NAC #ChemSky #DNAJunctions
Great success at the first IRN on Nucleic Acid Junctions meeting — inspiring science, engaging discussions, and exciting prospects.
Thanks to all, especially @dmonchaud.bsky.social for the leadership!
@cnrs.fr @akellett.bsky.social @granzhan.bsky.social
#IMAJ1 #ChemSky #DNAjunctions
Thanks to all, especially @dmonchaud.bsky.social for the leadership!
@cnrs.fr @akellett.bsky.social @granzhan.bsky.social
#IMAJ1 #ChemSky #DNAjunctions
May 14, 2025 at 6:24 PM
Great success at the first IRN on Nucleic Acid Junctions meeting — inspiring science, engaging discussions, and exciting prospects.
Thanks to all, especially @dmonchaud.bsky.social for the leadership!
@cnrs.fr @akellett.bsky.social @granzhan.bsky.social
#IMAJ1 #ChemSky #DNAjunctions
Thanks to all, especially @dmonchaud.bsky.social for the leadership!
@cnrs.fr @akellett.bsky.social @granzhan.bsky.social
#IMAJ1 #ChemSky #DNAjunctions
Excited to speak at the 1st International Meeting on Nucleic Acid Junctions (IMAJ#1) in Paris, May 12–14, 2025.
Grateful to be part of this great lineup. Thanks to Dr. David Monchaud and team!
#IMAJ2025 #DNAjunctions #ChemSky
Grateful to be part of this great lineup. Thanks to Dr. David Monchaud and team!
#IMAJ2025 #DNAjunctions #ChemSky
May 12, 2025 at 6:39 AM
Excited to speak at the 1st International Meeting on Nucleic Acid Junctions (IMAJ#1) in Paris, May 12–14, 2025.
Grateful to be part of this great lineup. Thanks to Dr. David Monchaud and team!
#IMAJ2025 #DNAjunctions #ChemSky
Grateful to be part of this great lineup. Thanks to Dr. David Monchaud and team!
#IMAJ2025 #DNAjunctions #ChemSky
Inspiring morning at @ciqus.bsky.social with @lsalassa.bsky.social, who showed how flavin photocatalysis can unlock new paths for platinum-based cancer therapies. Brilliant chemistry 🧪, sharp vision 💡
#chemsky #chembiosky
#chemsky #chembiosky
April 21, 2025 at 6:19 PM
Inspiring morning at @ciqus.bsky.social with @lsalassa.bsky.social, who showed how flavin photocatalysis can unlock new paths for platinum-based cancer therapies. Brilliant chemistry 🧪, sharp vision 💡
#chemsky #chembiosky
#chemsky #chembiosky
Great talk by Prof. Anna Peacock today at CiQUS!
Amazing work on de novo designed metalloproteins as MRI contrast agents.
Thanks for the inspiration!
@peacockgroup.bsky.social @ciqus.bsky.social
#CiQUS #ChemSky #BioinorganicChemistry #MRI
Amazing work on de novo designed metalloproteins as MRI contrast agents.
Thanks for the inspiration!
@peacockgroup.bsky.social @ciqus.bsky.social
#CiQUS #ChemSky #BioinorganicChemistry #MRI
April 10, 2025 at 1:16 PM
Great talk by Prof. Anna Peacock today at CiQUS!
Amazing work on de novo designed metalloproteins as MRI contrast agents.
Thanks for the inspiration!
@peacockgroup.bsky.social @ciqus.bsky.social
#CiQUS #ChemSky #BioinorganicChemistry #MRI
Amazing work on de novo designed metalloproteins as MRI contrast agents.
Thanks for the inspiration!
@peacockgroup.bsky.social @ciqus.bsky.social
#CiQUS #ChemSky #BioinorganicChemistry #MRI
Cytotoxicity tests revealed that these Cu(II) cyclopeptides outperform cisplatin in some cancer cell lines, with lower IC50 values and high efficacy.
#ChemSky #Metallopeptides #BioconjugateChem (4/5)
#ChemSky #Metallopeptides #BioconjugateChem (4/5)
March 10, 2025 at 3:57 PM
Cytotoxicity tests revealed that these Cu(II) cyclopeptides outperform cisplatin in some cancer cell lines, with lower IC50 values and high efficacy.
#ChemSky #Metallopeptides #BioconjugateChem (4/5)
#ChemSky #Metallopeptides #BioconjugateChem (4/5)
Using ICP-MS, we confirmed that these metallopeptides significantly increase intracellular Cu(II) levels.
Meanwhile, fluorescence assays showed a strong induction of ROS, supporting an oxidative stress-driven cytotoxic mechanism.
#ChemSky #Metallopeptides #BioconjugateChem (3/5)
Meanwhile, fluorescence assays showed a strong induction of ROS, supporting an oxidative stress-driven cytotoxic mechanism.
#ChemSky #Metallopeptides #BioconjugateChem (3/5)
March 10, 2025 at 3:56 PM
Using ICP-MS, we confirmed that these metallopeptides significantly increase intracellular Cu(II) levels.
Meanwhile, fluorescence assays showed a strong induction of ROS, supporting an oxidative stress-driven cytotoxic mechanism.
#ChemSky #Metallopeptides #BioconjugateChem (3/5)
Meanwhile, fluorescence assays showed a strong induction of ROS, supporting an oxidative stress-driven cytotoxic mechanism.
#ChemSky #Metallopeptides #BioconjugateChem (3/5)
In this study, we designed and synthesized novel Cu(II) metallopeptides that efficiently generate ROS inside cells, leading to high cytotoxic activity.
#ChemSky #Metallopeptides #BioconjugateChem (2/5)
#ChemSky #Metallopeptides #BioconjugateChem (2/5)
March 10, 2025 at 3:55 PM
In this study, we designed and synthesized novel Cu(II) metallopeptides that efficiently generate ROS inside cells, leading to high cytotoxic activity.
#ChemSky #Metallopeptides #BioconjugateChem (2/5)
#ChemSky #Metallopeptides #BioconjugateChem (2/5)
Just created an Instagram account to share updates on our research group! 🚀🔬 Follow us at @biometalusc to stay up to date with our latest advances in Supramolecular Chemistry & Chemical Biology! 🧪✨
March 2, 2025 at 5:47 PM
Just created an Instagram account to share updates on our research group! 🚀🔬 Follow us at @biometalusc to stay up to date with our latest advances in Supramolecular Chemistry & Chemical Biology! 🧪✨
My second-year Chemistry students at @usc.gal successfully obtained 🧡 copper via cementation! A hands-on approach to metal chemistry—reactivity in action! ⚗️🔥 #AcademicSky #ChemSky
February 27, 2025 at 8:03 PM
My second-year Chemistry students at @usc.gal successfully obtained 🧡 copper via cementation! A hands-on approach to metal chemistry—reactivity in action! ⚗️🔥 #AcademicSky #ChemSky
🚀 Exciting news! Our paper “Copper(II) cyclopeptides with high ROS-mediated cytotoxicity” has been accepted in Bioconjugate Chemistry! @pubs.acs.org 🎉
More details soon!
#Metallodrugs #ROS #BioconjugateChem #MetalPeptides #ChemSky
More details soon!
#Metallodrugs #ROS #BioconjugateChem #MetalPeptides #ChemSky
February 26, 2025 at 7:27 PM
🚀 Exciting news! Our paper “Copper(II) cyclopeptides with high ROS-mediated cytotoxicity” has been accepted in Bioconjugate Chemistry! @pubs.acs.org 🎉
More details soon!
#Metallodrugs #ROS #BioconjugateChem #MetalPeptides #ChemSky
More details soon!
#Metallodrugs #ROS #BioconjugateChem #MetalPeptides #ChemSky