Bravo to Alexander Fenton & Jean Chung! They discovered that Bruton's tyrosine kinase (Btk) assembles on membranes via weak proline-rich region (PRR)–SH3 interactions, enabling phase separation. Btk is a key player in B-cell development and a target in leukemia therapy.
🔗 buff.ly/KlAKcub
#Leukemia

Nicholas Vitari & team reveal that short-term morphine disrupts the gut microbiome & triggers immune complement activation. This suggests opioids may suppress homeostasis via host-microbe interactions—critical for chronic pain patients.
🔗 buff.ly/xeGEH8Q
#Immunology #Microbiota

Join the fight! Both individually and as a collective. There's no reason just to pick one

Many congratulations to Samrin Habbani and Sayeh Dowlatshahi from the Mohammed lab on another awesome discovery! They identified protein biomarkers for early cervical cancer detection. This could improve screening in underserved areas.
🔗https://buff.ly/YS59dny
#Cancer #Diagnostics #GlobalHealth

Many congratulations to Saranya Reghupaty and Laetitia Voilquin-Coassolo from the Svensson team on another awesome discovery! They found Ism1 loss triggers insulin resistance. This could point to new metabolic disease treatments.

🔗https://buff.ly/NTGFbpY

#Metabolism #Diabetes

Many congratulations to Jessica Regan and Christian DeJarnette from the Palmer lab on another awesome discovery! They found PanK is a key vulnerability in cancer cells. This could spark new selective cancer therapies.
🔗https://doi.org/10.1016/j.chembiol.2025.04.007
#CancerTherapy

Many congratulations to Luis Ontiveros-Padilla and Dylan Hendy from the @kristy-ainslie-lab.bsky.social on another awesome discovery! They developed a nanocomplex intranasal flu vaccine effective across strains. This could help create a universal, needle-free flu shot.
🔗 doi.org/10.1016/j.jc...

How writing funding applications be rn

Many congratulations to Yongqiang Chen and Yi Duan from the Schnabl team on another awesome discovery! They showed targeting bacterial KpsM reduces alcohol-related liver damage. This could advance microbiome-based therapies for liver disease.
🔗 doi.org/10.1016/j.ch...
#Microbiome

Many congratulations to Duy Phuong Hua and Jacob Kinnun from the Post lab on another awesome discovery! They found Syk kinase acts as a phospho-sensor via an electrostatic network. This could lead to protein-based biosensor designs.
🔗https://doi.org/10.1073/pnas.2421663122
#Science

Many congratulations to Bok-Soon Lee and Yea-In Park from the Kim lab on another awesome discovery! They found cholesterol enzymes DHCR7/DHCR24 drive colon cancer by generating ROS and activating JNK. This could open new doors for targeting cancer metabolism.
🔗 doi.org/10.1016/j.ca...
#Research

But I feel like the experience is more like getting one really good result and then chasing the dragon that doesn't exist

I feel like a lot of researchers will relate to this 1/2