* in 30 genes :)

Thank you for sharing!

Exiting (but difficult) task for the future is to find what makes some lineages better!

Pleiotropy is overated

Ooops. Thank you for spotting! I will ask them to fix...

Thank you! Nice to meet you. I really liked your eLife paper. doi.org/10.7554/eLif... It was very reassuring to see that 27Cys DHFR works.
No, we did not include mutational bias...

I am grateful to my collaborators @jaescudero.bsky.social
and Lucia Garcia-Pastor, my colleagues at the Anrdeas Wagner group. I am grateful to the reviewers for their helpful feedback and the Science production team for choosing a vivid illustration of a rugged landscape for the cover

To conclude, a high-dimensional landscape can be accessible to adaptive evolution, even when rugged. Future studies will show if other landscapes are similarly accessible. We hope this effort will both assist and inspire further theoretical work on fitness landscapes.

Interestingly, all high fitness peaks (27Asp and 27Glu) essentially share one enormous basin of attraction. This means that the evolving populations have access to multiple peaks, which makes it difficult to predict evolutionary outcomes.

It turned out that most genotypes have a large number of paths leading to high fitness peaks, and very few paths leading to low fitness peaks. Consequently, high peaks are evolutionary accessible to most genotypes (i.e. have large basins of attraction).

This result is robust against different population genetics assumptions