@bingjiayan.bsky.social
Chemical protein synthesis. Chemist with passion of proteins relating to neurodegenerative disease.
Reposted
Cool stuff from our collaboration with @mxhend.bsky.social: the fold of tau filaments matters for seeding in primary cultures & in live mice: the AD fold is more seeding efficient than non-AD folds! But that's not all: phosphorylation of the fuzzy coat matters too. 🤩
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Seed structure and phosphorylation in the fuzzy coat impact tau seeding competency
Tau is a pathogenic protein in Alzheimer's (AD) and other neurodegenerative diseases. The misfolding of tau into beta-sheet rich elongated filaments is thought to be a key event in disease pathogenesi...
www.biorxiv.org
March 12, 2025 at 4:54 PM
Cool stuff from our collaboration with @mxhend.bsky.social: the fold of tau filaments matters for seeding in primary cultures & in live mice: the AD fold is more seeding efficient than non-AD folds! But that's not all: phosphorylation of the fuzzy coat matters too. 🤩
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...