Billadeau Lab
@billadeaulab.bsky.social
Immunologist and Cancer Biologist 🧪
Longtime interest in Natural Killer cells and CD8+ T cells
Cell Biology, Biochemistry and Microscopy, in no special order
Opinions are my own
Editor at The Journal of Cell Science
Longtime interest in Natural Killer cells and CD8+ T cells
Cell Biology, Biochemistry and Microscopy, in no special order
Opinions are my own
Editor at The Journal of Cell Science
Just got news that our NIDDK T32 training grant renewal has been funded. Looking forward to training more PhD candidates in various digestive diseases. It’s been a long haul, but we made it.
August 28, 2025 at 10:58 PM
Just got news that our NIDDK T32 training grant renewal has been funded. Looking forward to training more PhD candidates in various digestive diseases. It’s been a long haul, but we made it.
Reflections are look into the past. Maybe just a few femtoseconds depending on the distance from the object and the observer, but the past nonetheless.
#Photography
#Photography
July 8, 2025 at 6:48 PM
Reflections are look into the past. Maybe just a few femtoseconds depending on the distance from the object and the observer, but the past nonetheless.
#Photography
#Photography
Reposted by Billadeau Lab
The scientific and medical communities are stepping up to safeguard the systems they helped build over decades. In moments like this, it’s important to affirm the role of science and evidence in guiding public health decisions. 💉🛟
www.statnews.com/2025/07/03/v...
www.statnews.com/2025/07/03/v...
The U.S. government is failing on vaccine policy. The Vaccine Integrity Project is here to help
The Vaccine Integrity Project will convene experts to assess the evidence on influenza, RSV, and Covid-19 to equip clinicians with reliable, evidence-based information.
www.statnews.com
July 8, 2025 at 3:22 PM
The scientific and medical communities are stepping up to safeguard the systems they helped build over decades. In moments like this, it’s important to affirm the role of science and evidence in guiding public health decisions. 💉🛟
www.statnews.com/2025/07/03/v...
www.statnews.com/2025/07/03/v...
Reposted by Billadeau Lab
For the night of the new moon, my OH tracked the desert stars again with camera & tripod.
I can’t get over the wonder of this, even just the colour variations of the distinct paths. If you know the celestial opening sequence of the 1946 film A Matter of Life & Death — it makes me think of that.
I can’t get over the wonder of this, even just the colour variations of the distinct paths. If you know the celestial opening sequence of the 1946 film A Matter of Life & Death — it makes me think of that.
June 25, 2025 at 1:05 PM
For the night of the new moon, my OH tracked the desert stars again with camera & tripod.
I can’t get over the wonder of this, even just the colour variations of the distinct paths. If you know the celestial opening sequence of the 1946 film A Matter of Life & Death — it makes me think of that.
I can’t get over the wonder of this, even just the colour variations of the distinct paths. If you know the celestial opening sequence of the 1946 film A Matter of Life & Death — it makes me think of that.
A fellow in the lab who has been leading the natural killer cell therapy projects is heading off to do a clinical fellowship in Immune Cell Therapy. He gave me a parting gift that he made from a microscope he bought on eBay. Very cool and creative gift.
#Science 🧪
#Science 🧪
June 24, 2025 at 6:42 PM
A fellow in the lab who has been leading the natural killer cell therapy projects is heading off to do a clinical fellowship in Immune Cell Therapy. He gave me a parting gift that he made from a microscope he bought on eBay. Very cool and creative gift.
#Science 🧪
#Science 🧪
This mama duck has her wings full. Nine, not so little ducklings.
June 16, 2025 at 4:26 PM
This mama duck has her wings full. Nine, not so little ducklings.
Mamma and her little ducklings paid the research building a visit today.
June 11, 2025 at 7:16 PM
Mamma and her little ducklings paid the research building a visit today.
Reposted by Billadeau Lab
Can we reduce metastasis in pancreatic cancer?
Kawai et al. show PBRM1 is a tumor suppressor controlling tumor grade and metastasis of pancreatic ductal adenocarcinoma by regulating vimentin—and metastasis is reduced with vimentin inhibition in mice: buff.ly/znLWXzs
Kawai et al. show PBRM1 is a tumor suppressor controlling tumor grade and metastasis of pancreatic ductal adenocarcinoma by regulating vimentin—and metastasis is reduced with vimentin inhibition in mice: buff.ly/znLWXzs
June 11, 2025 at 1:22 PM
Can we reduce metastasis in pancreatic cancer?
Kawai et al. show PBRM1 is a tumor suppressor controlling tumor grade and metastasis of pancreatic ductal adenocarcinoma by regulating vimentin—and metastasis is reduced with vimentin inhibition in mice: buff.ly/znLWXzs
Kawai et al. show PBRM1 is a tumor suppressor controlling tumor grade and metastasis of pancreatic ductal adenocarcinoma by regulating vimentin—and metastasis is reduced with vimentin inhibition in mice: buff.ly/znLWXzs
Out pond fishing last week with my son. Skunked him 7-0. Had a good time watching some sunfish defend their spawn beds. Such bloviating behavior from these little guys.😁
June 11, 2025 at 12:35 PM
Out pond fishing last week with my son. Skunked him 7-0. Had a good time watching some sunfish defend their spawn beds. Such bloviating behavior from these little guys.😁
May 31, 2025 at 10:54 AM
This is for all my science followers out there, since many of the others won’t really get it, w/o a backstory. Just know, a certain company’s antibodies really SUCK! We all know it, but continue to get lured in like Charlie Brown kicking the football that Lucy is holding.
May 31, 2025 at 12:10 AM
This is for all my science followers out there, since many of the others won’t really get it, w/o a backstory. Just know, a certain company’s antibodies really SUCK! We all know it, but continue to get lured in like Charlie Brown kicking the football that Lucy is holding.
Looking forward to the reveal of some of the phase 2 data at ASCO tomorrow re: Elraglusib. Apparently it is +.
My lab identified the target (GSK-3 beta - a kinase) in pancreatic cancer in 2005, and worked on the small molecule with the medicinal chemist, publishing the first paper on it in 2009.
My lab identified the target (GSK-3 beta - a kinase) in pancreatic cancer in 2005, and worked on the small molecule with the medicinal chemist, publishing the first paper on it in 2009.
May 30, 2025 at 10:30 PM
Looking forward to the reveal of some of the phase 2 data at ASCO tomorrow re: Elraglusib. Apparently it is +.
My lab identified the target (GSK-3 beta - a kinase) in pancreatic cancer in 2005, and worked on the small molecule with the medicinal chemist, publishing the first paper on it in 2009.
My lab identified the target (GSK-3 beta - a kinase) in pancreatic cancer in 2005, and worked on the small molecule with the medicinal chemist, publishing the first paper on it in 2009.
Got a nice surprise from the NIH today - a Notice of Grant Award.
April 30, 2025 at 2:14 PM
Got a nice surprise from the NIH today - a Notice of Grant Award.
Reposted by Billadeau Lab
We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....
February 27, 2025 at 3:54 PM
We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....
Just in case you want a little science with your morning coffee on Science Sunday. 🧪
ASCB Celldance 2014-Cytotoxic T-Cells on Patrol-Alex Ritter HD
YouTube video by American Society for Cell Biology
youtu.be
April 27, 2025 at 12:11 PM
Just in case you want a little science with your morning coffee on Science Sunday. 🧪
Had a nice leisurely 3.6 mile stroll around Lake Winona earlier this week with the Mrs. Here’s an up close and personal shot of Sugar Loaf, an outcropping on the bluff that can be seen in the far distance of the first photo.
#Photography #Minneosta
#Photography #Minneosta
April 27, 2025 at 11:45 AM
Had a nice leisurely 3.6 mile stroll around Lake Winona earlier this week with the Mrs. Here’s an up close and personal shot of Sugar Loaf, an outcropping on the bluff that can be seen in the far distance of the first photo.
#Photography #Minneosta
#Photography #Minneosta
Reposted by Billadeau Lab
Take the time to leave a public comment. Political appointees should not drive science forward...evidence should.
www.federalregister.gov/documents/20...
www.federalregister.gov/documents/20...
April 24, 2025 at 8:59 AM
Take the time to leave a public comment. Political appointees should not drive science forward...evidence should.
www.federalregister.gov/documents/20...
www.federalregister.gov/documents/20...
Winona, MN received Cherry Blossom Trees from it’s sister city — Misato, Japan 13 years ago, which they planted around Lake Winona. They were in nearly full bloom today. #Photography
April 24, 2025 at 1:02 AM
Winona, MN received Cherry Blossom Trees from it’s sister city — Misato, Japan 13 years ago, which they planted around Lake Winona. They were in nearly full bloom today. #Photography
Reposted by Billadeau Lab
Microbial metabolite drives ageing-related clonal hematopoiesis via ALPK1 @nature.com
www.nature.com/articles/s41...
Congrats Dan Starczynowski @cincyresearch.bsky.social
www.nature.com/articles/s41...
Congrats Dan Starczynowski @cincyresearch.bsky.social
April 23, 2025 at 3:54 PM
Microbial metabolite drives ageing-related clonal hematopoiesis via ALPK1 @nature.com
www.nature.com/articles/s41...
Congrats Dan Starczynowski @cincyresearch.bsky.social
www.nature.com/articles/s41...
Congrats Dan Starczynowski @cincyresearch.bsky.social
This is so darn funny. Especially for all of us grant writers.😂
April 23, 2025 at 1:23 AM
This is so darn funny. Especially for all of us grant writers.😂
Here’s a scanning electron microscopy image of a cytotoxic CD8 T cell scanning a tumor cell. Note the lammelipodial filamentous actin-rich protrusion beginning to envelope the tumor cell. My group has identified dozens of proteins involved in this critical process required for cell killing. 🧪
April 22, 2025 at 12:22 AM
Here’s a scanning electron microscopy image of a cytotoxic CD8 T cell scanning a tumor cell. Note the lammelipodial filamentous actin-rich protrusion beginning to envelope the tumor cell. My group has identified dozens of proteins involved in this critical process required for cell killing. 🧪
My lab has had a long-standing interest in uncovering the mechanisms by which natural killer cells deliver the ‘lethal’ hit to tumor cells. We use a lot of immunofluorecence microscopy to examine the various stages of killing. Sometimes interesting images emerge, such as this acorn image below. 🧪
April 21, 2025 at 7:42 PM
My lab has had a long-standing interest in uncovering the mechanisms by which natural killer cells deliver the ‘lethal’ hit to tumor cells. We use a lot of immunofluorecence microscopy to examine the various stages of killing. Sometimes interesting images emerge, such as this acorn image below. 🧪
Reposted by Billadeau Lab
The biotech company Colossal Biosciences declared on Monday it had “resurrected” the dire wolf. The bold claim was immediately met with skepticism and outrage from scientists on social media. scim.ag/42imbGU
Is the dire wolf back from the dead? Not exactly
Genetically edited gray wolf pups became instant media darlings—and drew hefty skepticism from scientists
scim.ag
April 8, 2025 at 9:56 PM
The biotech company Colossal Biosciences declared on Monday it had “resurrected” the dire wolf. The bold claim was immediately met with skepticism and outrage from scientists on social media. scim.ag/42imbGU
A great editorial for the inaugural issue of the Journal of Human Immunology, by the Editor-in-Chief, Dr Jean-Laurent Casanova.
Remember, your adaptive immune system just barely tolerates you.
Remember, your adaptive immune system just barely tolerates you.
Human immunity | Journal of Human Immunity | Rockefeller University Press
Human immunity is often insufficient against infectious agents and sometimes over-reactive to innocuous components of the environment or the human body. Ge
rupress.org
April 8, 2025 at 4:34 PM
A great editorial for the inaugural issue of the Journal of Human Immunology, by the Editor-in-Chief, Dr Jean-Laurent Casanova.
Remember, your adaptive immune system just barely tolerates you.
Remember, your adaptive immune system just barely tolerates you.
Reposted by Billadeau Lab
Measles can ‘erase’ your immune system’s memory globalnews.ca/news/1111130... @kdangerfield.bsky.social
𝗚𝗲𝘁 𝘄𝗲𝗲𝗸𝗹𝘆 𝘂𝗽𝗱𝗮𝘁𝗲𝘀: CanadaHealthwatch.ca/newsletter 🍁
𝗚𝗲𝘁 𝘄𝗲𝗲𝗸𝗹𝘆 𝘂𝗽𝗱𝗮𝘁𝗲𝘀: CanadaHealthwatch.ca/newsletter 🍁
April 5, 2025 at 2:43 AM
Measles can ‘erase’ your immune system’s memory globalnews.ca/news/1111130... @kdangerfield.bsky.social
𝗚𝗲𝘁 𝘄𝗲𝗲𝗸𝗹𝘆 𝘂𝗽𝗱𝗮𝘁𝗲𝘀: CanadaHealthwatch.ca/newsletter 🍁
𝗚𝗲𝘁 𝘄𝗲𝗲𝗸𝗹𝘆 𝘂𝗽𝗱𝗮𝘁𝗲𝘀: CanadaHealthwatch.ca/newsletter 🍁