@bilderlab
@bilderlab.bsky.social
Epithelial biology: polarizing proteins, elongating eggs, and cold-blooded cancer
Reposted by @bilderlab
FWIW we also find that flies show coagulopathy, another big cause of death of cancer patients pubmed.ncbi.nlm.nih.gov/37354901/
Systemic coagulopathy promotes host lethality in a new Drosophila tumor model - PubMed
Malignant tumors trigger a complex network of inflammatory and wound repair responses, prompting Dvorak's characterization of tumors as "wounds that never heal."<sup>1</sup> Some of these responses le...
pubmed.ncbi.nlm.nih.gov
October 18, 2025 at 2:45 PM
FWIW we also find that flies show coagulopathy, another big cause of death of cancer patients pubmed.ncbi.nlm.nih.gov/37354901/
Reposted by @bilderlab
Maybe referring to a 2015 paper from our lab? pubmed.ncbi.nlm.nih.gov/25850672/ @perrimonlab.bsky.social published back-to-back: pubmed.ncbi.nlm.nih.gov/25850671/.
Malignant Drosophila tumors interrupt insulin signaling to induce cachexia-like wasting - PubMed
Tumors kill patients not only through well-characterized perturbations to their local environment but also through poorly understood pathophysiological interactions with distant tissues. Here, we use ...
pubmed.ncbi.nlm.nih.gov
October 18, 2025 at 2:29 PM
Maybe referring to a 2015 paper from our lab? pubmed.ncbi.nlm.nih.gov/25850672/ @perrimonlab.bsky.social published back-to-back: pubmed.ncbi.nlm.nih.gov/25850671/.
Shoshin - Wikipedia
en.wikipedia.org
October 18, 2025 at 2:51 PM
FWIW we also find that flies show coagulopathy, another big cause of death of cancer patients pubmed.ncbi.nlm.nih.gov/37354901/
Systemic coagulopathy promotes host lethality in a new Drosophila tumor model - PubMed
Malignant tumors trigger a complex network of inflammatory and wound repair responses, prompting Dvorak's characterization of tumors as "wounds that never heal."<sup>1</sup> Some of these responses le...
pubmed.ncbi.nlm.nih.gov
October 18, 2025 at 2:45 PM
FWIW we also find that flies show coagulopathy, another big cause of death of cancer patients pubmed.ncbi.nlm.nih.gov/37354901/
None necessary! Hoping future flaming elmos come our way.
October 18, 2025 at 2:41 PM
None necessary! Hoping future flaming elmos come our way.
Much better-informed folks actually wrote a review on this last year: pubmed.ncbi.nlm.nih.gov/38898221/
Why do patients with cancer die? - PubMed
Cancer is a major cause of global mortality, both in affluent countries and increasingly in developing nations. Many patients with cancer experience reduced life expectancy and have metastatic disease...
pubmed.ncbi.nlm.nih.gov
October 18, 2025 at 2:39 PM
Much better-informed folks actually wrote a review on this last year: pubmed.ncbi.nlm.nih.gov/38898221/
We got into this because I guess I have the mind of a 7 year old and didn't understand 'how does cancer kill' -- thought flies could give insight. some info in this from @natrevcancer.nature.com pubmed.ncbi.nlm.nih.gov/34389815/
October 18, 2025 at 2:36 PM
We got into this because I guess I have the mind of a 7 year old and didn't understand 'how does cancer kill' -- thought flies could give insight. some info in this from @natrevcancer.nature.com pubmed.ncbi.nlm.nih.gov/34389815/
Maybe referring to a 2015 paper from our lab? pubmed.ncbi.nlm.nih.gov/25850672/ @perrimonlab.bsky.social published back-to-back: pubmed.ncbi.nlm.nih.gov/25850671/.
Malignant Drosophila tumors interrupt insulin signaling to induce cachexia-like wasting - PubMed
Tumors kill patients not only through well-characterized perturbations to their local environment but also through poorly understood pathophysiological interactions with distant tissues. Here, we use ...
pubmed.ncbi.nlm.nih.gov
October 18, 2025 at 2:29 PM
Maybe referring to a 2015 paper from our lab? pubmed.ncbi.nlm.nih.gov/25850672/ @perrimonlab.bsky.social published back-to-back: pubmed.ncbi.nlm.nih.gov/25850671/.
We have also donated our anti-Grnd (one of two #Drosophila TNF Receptors) monoclonal —coming soon (5/5)
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A Drosophila Tumor Suppressor Gene Prevents Tonic TNF Signaling through Receptor N-Glycosylation
Drosophila tumor suppressor genes have revealed molecular pathways that control tissue growth, but mechanisms that regulate mitogenic signaling are fa…
www.sciencedirect.com
February 25, 2025 at 7:25 PM
We have also donated our anti-Grnd (one of two #Drosophila TNF Receptors) monoclonal —coming soon (5/5)
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Anti-Hemese staining of plasmatocytes —essentially #Drosophila macrophages. Dm 1.2/1. Image by Yoshiki Sakai in the lab. (4/5)
February 25, 2025 at 7:25 PM
Anti-Hemese staining of plasmatocytes —essentially #Drosophila macrophages. Dm 1.2/1. Image by Yoshiki Sakai in the lab. (4/5)
Anti-NimC1 staining of plasmatocytes —essentially #Drosophila macrophages. Combination of Dm N1/9 and Dm N47/7. Image by Yoshiki Sakai in the lab. (3/5)
February 25, 2025 at 7:25 PM
Anti-NimC1 staining of plasmatocytes —essentially #Drosophila macrophages. Combination of Dm N1/9 and Dm N47/7. Image by Yoshiki Sakai in the lab. (3/5)
These donations continue the spirit of the “Fly worker ethos” —others are encouraged to do the same! (2/5)
pubmed.ncbi.nlm.nih.gov/28684603/
pubmed.ncbi.nlm.nih.gov/28684603/
February 25, 2025 at 7:25 PM
These donations continue the spirit of the “Fly worker ethos” —others are encouraged to do the same! (2/5)
pubmed.ncbi.nlm.nih.gov/28684603/
pubmed.ncbi.nlm.nih.gov/28684603/