Are you thinking about yourself or the students? 😀. After 2hrs of teaching, i feel typically like i ran a cognitive marathon...

Thanks!

Thanks!

Thanks!

Thanks. Still thinking about an appropriate walk up song for this 🙃.

Thanks! We do not exclude an additional role for modifications/heterogeneity. But our data suggests that levels are at least sufficient for the effects observed: direct (and presumably modification unspecific) depletion of R-proteins to a similar degree had the same effect on growth as maternal DR.

Read full article here: biorxiv.org/content/10.1...
Thanks to our collaborator
@nstroustrup.bsky.social, @snsf-ch.bsky.social
for funding, and
@embl.org / @embo.org YIP for proteomics support.

In summary, we find that intergenerational control of core cellular machinery, such as the ribosome, can transmit information about the metabolic state from parent to offspring. This intergenerational control may prime offspring for their expected environmental conditions.