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🚨 Join us for the LS2 Swiss #Systems #Biology Symposium in Bern!

❌ to talk marathons
✔️ to new connections and interactions

➡️Mini parallel sessions with Q&A during the talks.

Keynotes by @ehannezo.bsky.social @leeat-keren.bsky.social

tinyurl.com/5hf485ee

@lifesciswitzerland.bsky.social

In summary, we find that intergenerational control of core cellular machinery, such as the ribosome, can transmit information about the metabolic state from parent to offspring. This intergenerational control may prime offspring for their expected environmental conditions.

The control of progeny ribosomes involved specific regulation in the mother: soma-specific maternal inhibition of mTOR signaling fully recapitulated the effects of maternal dietary restriction, suggesting that mTOR transmits information across the germline-soma boundary.

Reduced ribosomes had physiological consequences: when offspring were switched to abundant food, they grew slower until they had restored normal ribosome levels. Thus, their translation capacity became a developmental bottleneck.

We explored this question using #dietary #restriction of #Celegans combining #proteomics and live #imaging. We found that while most proteins are reset between generations, ribosomal proteins remained low also in the offspring of dietarily restricted mothers.

In bacteria, studies going back to 1950s showed that the growth rate and ribosome expression are indeed tightly connected by a linear relation called the “growth law”. But such growth laws have rarely been studied in animals.

Join us for the 2nd LS2_Systems_Biology *Theory across Biology* workshop #TaB2024 in Bern on 14 June 2024. From molecules to ecosystems. No PPTs, black board only! Flipcharts instead of posters! For theorists *and* experimentalists.
shorturl.at/hDST1