Bernd Plietker
berndplietker.bsky.social
Bernd Plietker
@berndplietker.bsky.social
Chemist with a passion for catalysis, medicinal chemistry, and... gardening. Father of three, husband.
Reposted by Bernd Plietker
Beautiful O-GlcNAc review by @scheng23.bsky.social and Alison from the Woo lab #glycotime
pubs.acs.org/doi/10.1021/...
Opportunities for Therapeutic Modulation of O-GlcNAc
O-Linked β-N-acetylglucosamine (O-GlcNAc) is an essential, dynamic monosaccharide post-translational modification (PTM) found on serine and threonine residues of thousands of nucleocytoplasmic proteins. The installation and removal of O-GlcNAc is controlled by a single pair of enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), respectively. Since its discovery four decades ago, O-GlcNAc has been found on diverse classes of proteins, playing important functional roles in many cellular processes. Dysregulation of O-GlcNAc homeostasis has been implicated in the pathogenesis of disease, including neurodegeneration, X-linked intellectual disability (XLID), cancer, diabetes, and immunological disorders. These foundational studies of O-GlcNAc in disease biology have motivated efforts to target O-GlcNAc therapeutically, with multiple clinical candidates under evaluation. In this review, we describe the characterization and biochemistry of OGT and OGA, cellular O-GlcNAc regulation, development of OGT and OGA inhibitors, O-GlcNAc in pathophysiology, clinical progress of O-GlcNAc modulators, and emerging opportunities for targeting O-GlcNAc. This comprehensive resource should motivate further study into O-GlcNAc function and inspire strategies for therapeutic modulation of O-GlcNAc.
pubs.acs.org
November 15, 2024 at 3:33 PM
Reposted by Bernd Plietker
Recent paper (Nature)-why are males more vulnerable to severe infections (ex acute #COVID), while females suffer more from autoimmunity (SLE, MS etc and also #LongCovid)? X/Y or hormones? We study adaptation of immune systems in gender-affirming testosterone treatment: nature.com/articles/s41...
Immune system adaptation during gender-affirming testosterone treatment - Nature
Examination of immunological changes in transgender individuals undergoing gender-affirming testosterone treatment reveals sex hormone-regulated pathways in humans and explains sex-divergent responses...
nature.com
November 17, 2024 at 6:57 AM
Reposted by Bernd Plietker
See the paper & Supp Notes for the full story of our collaboration community's awesome work - from design, synthesis, switching, cell culture, primary culture, tissue slice, right through to organ sections!

So: the take-home?

Caveat Optogenetics - the chemists are coming for you now!

doi.org/m75j
November 18, 2024 at 2:25 AM