Ben Morehouse
@benmorehouse.bsky.social
Assistant Professor at UCIrvine. Biochemistry and structural biology enthusiast. Dabbling in innate immunity and microbiology. Phage defense, cyclic nucleotides, and cool enzymes. (he/him/his) https://faculty.sites.uci.edu/morehouselab/
Reposted by Ben Morehouse
I'd also like to highlight a recent publication by @audeber.bsky.social, @enzopoirier.bsky.social, and colleagues showing FAM118B, which they term "SIRal", is essential for innate immune response in mammalian cellular models; they also have great phylogenetic analysis and insights into biochemistry.
A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway
Key actors of mammalian immunity originated from bacterial antiphage systems. The full extent of immune system conservation between bacteria and eukaryotes is unknown. Here, we show that the silent in...
www.science.org
November 17, 2025 at 2:16 PM
I'd also like to highlight a recent publication by @audeber.bsky.social, @enzopoirier.bsky.social, and colleagues showing FAM118B, which they term "SIRal", is essential for innate immune response in mammalian cellular models; they also have great phylogenetic analysis and insights into biochemistry.