Benjamin D. Greenbaum
@bengrbm.bsky.social
Member, Memorial Sloan Kettering Cancer Center
Co-Director, Olayan Center for Cancer Vaccines
Comp Immuno-oncology
Self/nonself theory
Co-Founder Rome Therapeutics
Physicist
Co-Director, Olayan Center for Cancer Vaccines
Comp Immuno-oncology
Self/nonself theory
Co-Founder Rome Therapeutics
Physicist
I would usually write a summary but I will defer to the text this time and just express thanks for the interactions and experiences this work generated. Its been a gateway into a lot of fun science that we are still unpacking...
October 2, 2025 at 2:20 PM
I would usually write a summary but I will defer to the text this time and just express thanks for the interactions and experiences this work generated. Its been a gateway into a lot of fun science that we are still unpacking...
The main predictor of LINE-1 activity is if p53, the most mutated gene in cancer, is mutated. This is a deep evolutionary relationship. We mathematically modeled the dependence of LINE-1 action on p53 status, finding a mixture of transcriptional and genomic regulation:
March 7, 2025 at 3:41 PM
The main predictor of LINE-1 activity is if p53, the most mutated gene in cancer, is mutated. This is a deep evolutionary relationship. We mathematically modeled the dependence of LINE-1 action on p53 status, finding a mixture of transcriptional and genomic regulation:
We were able to rank tumor types by their "RT burden" - the degree to which new LINE-1 insertions happen in the self genome & also capture locus specific transcriptional heterogeneity:
March 7, 2025 at 3:40 PM
We were able to rank tumor types by their "RT burden" - the degree to which new LINE-1 insertions happen in the self genome & also capture locus specific transcriptional heterogeneity: