Benjamin D. Greenbaum
@bengrbm.bsky.social
Member, Memorial Sloan Kettering Cancer Center
Co-Director, Olayan Center for Cancer Vaccines
Comp Immuno-oncology
Self/nonself theory
Co-Founder Rome Therapeutics
Physicist
Co-Director, Olayan Center for Cancer Vaccines
Comp Immuno-oncology
Self/nonself theory
Co-Founder Rome Therapeutics
Physicist
Thank you @mskcancercenter.bsky.social for highlighting our work on #viralmimicry in our genome, its evolution, the selective forces on it, and its potential role in cancer.
A great years long collaborative effort with @petrsulc.bsky.social, @daniel-decarvalho.bsky.social, & many great colleagues!
A great years long collaborative effort with @petrsulc.bsky.social, @daniel-decarvalho.bsky.social, & many great colleagues!
Dr. @bengrbm.bsky.social has tried to shed light on the innate immune system and how it affects cancer cells as they evolve.
Now Dr. Greenbaum’s lab has been taking a deep dive into modeling viral mimicry, trying to understand how this could shape cancer cells’ development process. bit.ly/3VWadA8
Now Dr. Greenbaum’s lab has been taking a deep dive into modeling viral mimicry, trying to understand how this could shape cancer cells’ development process. bit.ly/3VWadA8
October 8, 2025 at 11:56 PM
Thank you @mskcancercenter.bsky.social for highlighting our work on #viralmimicry in our genome, its evolution, the selective forces on it, and its potential role in cancer.
A great years long collaborative effort with @petrsulc.bsky.social, @daniel-decarvalho.bsky.social, & many great colleagues!
A great years long collaborative effort with @petrsulc.bsky.social, @daniel-decarvalho.bsky.social, & many great colleagues!
Sharing a paper below in Cell Genomics @cellpress.bsky.social
that took us literally 10 years+ (!) to write on the topics of:
that took us literally 10 years+ (!) to write on the topics of:
Cell Press: Cell Genomics
Gold open access and open science journal providing a high-profile forum for major advances in genetics, genomics, and genome technology.
cell.com
October 2, 2025 at 2:14 PM
Sharing a paper below in Cell Genomics @cellpress.bsky.social
that took us literally 10 years+ (!) to write on the topics of:
that took us literally 10 years+ (!) to write on the topics of:
Reposted by Benjamin D. Greenbaum
Excited to have this paper out today!
Repeats mimic pathogen-associated patterns across a vast evolutionary landscape."
It was a fun and productive collaboration with Benjamin Greenbaum John LaCava, Simona Cocco, Petr Šulc and many others!
www.cell.com/cell-genomic...
Repeats mimic pathogen-associated patterns across a vast evolutionary landscape."
It was a fun and productive collaboration with Benjamin Greenbaum John LaCava, Simona Cocco, Petr Šulc and many others!
www.cell.com/cell-genomic...
Repeats mimic pathogen-associated patterns across a vast evolutionary landscape
An emerging hallmark of disease is transcription of pathogen-associated molecular
patterns from within the genome–known as viral mimicry. We propose a statistical physics
framework to measure “selecti...
www.cell.com
September 26, 2025 at 2:36 PM
Excited to have this paper out today!
Repeats mimic pathogen-associated patterns across a vast evolutionary landscape."
It was a fun and productive collaboration with Benjamin Greenbaum John LaCava, Simona Cocco, Petr Šulc and many others!
www.cell.com/cell-genomic...
Repeats mimic pathogen-associated patterns across a vast evolutionary landscape."
It was a fun and productive collaboration with Benjamin Greenbaum John LaCava, Simona Cocco, Petr Šulc and many others!
www.cell.com/cell-genomic...
Reposted by Benjamin D. Greenbaum
Nice to see this story out! The idea that viral mimicry is an intrinsic feedback mechanism for sensing cellular dysregulation is fascinating and this paper explores this idea really well.
It was inspiring to be part of this collaborative work. Thanks to @bengrbm.bsky.social and the rest!
It was inspiring to be part of this collaborative work. Thanks to @bengrbm.bsky.social and the rest!
Repeats mimic pathogen-associated patterns across a vast evolutionary landscape
An emerging hallmark of disease is transcription of pathogen-associated molecular
patterns from within the genome–known as viral mimicry. We propose a statistical physics
framework to measure “selecti...
www.cell.com
September 25, 2025 at 8:20 AM
Nice to see this story out! The idea that viral mimicry is an intrinsic feedback mechanism for sensing cellular dysregulation is fascinating and this paper explores this idea really well.
It was inspiring to be part of this collaborative work. Thanks to @bengrbm.bsky.social and the rest!
It was inspiring to be part of this collaborative work. Thanks to @bengrbm.bsky.social and the rest!
Reposted by Benjamin D. Greenbaum
Early registration rates end this coming Monday for #mDNASRC. Join your colleagues in beautiful Porto alongside organizers like @bengrbm.bsky.social. Save your space: buff.ly/P6hZjQz
June 24, 2025 at 1:19 PM
Early registration rates end this coming Monday for #mDNASRC. Join your colleagues in beautiful Porto alongside organizers like @bengrbm.bsky.social. Save your space: buff.ly/P6hZjQz
Reposted by Benjamin D. Greenbaum
MSK is pleased to announce @time.com has named two MSK physician-scientists, Dr. Andrea Cercek and Dr. Vinod Balachandran, to the 2025 TIME100 Health, a list of the most influential individuals in health and medicine who have made significant contributions to industry.
Learn more: bit.ly/3GGblTR
Learn more: bit.ly/3GGblTR
May 8, 2025 at 2:26 PM
MSK is pleased to announce @time.com has named two MSK physician-scientists, Dr. Andrea Cercek and Dr. Vinod Balachandran, to the 2025 TIME100 Health, a list of the most influential individuals in health and medicine who have made significant contributions to industry.
Learn more: bit.ly/3GGblTR
Learn more: bit.ly/3GGblTR
Reposted by Benjamin D. Greenbaum
Call for abstracts! #mDNASRC is in beautiful Porto this year! Organizers @bengrbm.bsky.social, John LaCava, Zhao Zhang, and Vera Gorbunova may select you for a poster session or short talk. You can even register now and submit your abstract later. Save your space: buff.ly/PAKp55o
May 7, 2025 at 1:04 PM
Call for abstracts! #mDNASRC is in beautiful Porto this year! Organizers @bengrbm.bsky.social, John LaCava, Zhao Zhang, and Vera Gorbunova may select you for a poster session or short talk. You can even register now and submit your abstract later. Save your space: buff.ly/PAKp55o
Come out tomorrow at 10 am to learn about transposable elements in cancer - it will be a great session with @chiappinellilab.bsky.social & Ting Wang #AACR25! @theaacr.bsky.social
Looking forward to #AACR25! If you want to learn more about transposable elements in cancer, our educational session is at 10 am on Saturday 4/26!
@bengrbm.bsky.social @theaacr.bsky.social
@bengrbm.bsky.social @theaacr.bsky.social
April 25, 2025 at 2:09 PM
Come out tomorrow at 10 am to learn about transposable elements in cancer - it will be a great session with @chiappinellilab.bsky.social & Ting Wang #AACR25! @theaacr.bsky.social
Great article in @science.org highlighting our efforts to target the #darkproteome!
Nice to see our colleagues David Ting, Daniel De Carvalho, and Marty Taylor highlighted along with the amazing work of @rometx.bsky.social👇👇👇
www.science.org/content/arti...
Nice to see our colleagues David Ting, Daniel De Carvalho, and Marty Taylor highlighted along with the amazing work of @rometx.bsky.social👇👇👇
www.science.org/content/arti...
Could blocking ‘jumping genes’ help fight disease and aging?
The first clinical trials are testing inhibitors of transposons, DNA sequences that hop around the genome on their own
www.science.org
April 19, 2025 at 7:49 PM
Great article in @science.org highlighting our efforts to target the #darkproteome!
Nice to see our colleagues David Ting, Daniel De Carvalho, and Marty Taylor highlighted along with the amazing work of @rometx.bsky.social👇👇👇
www.science.org/content/arti...
Nice to see our colleagues David Ting, Daniel De Carvalho, and Marty Taylor highlighted along with the amazing work of @rometx.bsky.social👇👇👇
www.science.org/content/arti...
Reposted by Benjamin D. Greenbaum
#mDNASRC is back and stronger than ever after 30 years! Discover how transposable elements shape our genomes and impact health, featuring keynote speaker @bengrbm.bsky.social, and more! Save your space: buff.ly/QiSc4E6
April 14, 2025 at 3:30 PM
#mDNASRC is back and stronger than ever after 30 years! Discover how transposable elements shape our genomes and impact health, featuring keynote speaker @bengrbm.bsky.social, and more! Save your space: buff.ly/QiSc4E6
Thank you @mskcancercenter.bsky.social for highlighting our work and our great collaborators!
(1/2) MSK researchers are trying to understand how the immune system senses cancer in order to make better #immunotherapies.
April 2, 2025 at 8:19 PM
Thank you @mskcancercenter.bsky.social for highlighting our work and our great collaborators!
Our latest work on the #darkgenome is out now in @naturecomms.bsky.social. LINE-1 is the only known autonomous retrotransposon still active in our genome. Co-led by our Alexander Solovyov @MSKCancerCenter - our work was also great collaboration with @rome_tx 👇👇👇
nature.com/articles/s4146
nature.com/articles/s4146
March 7, 2025 at 3:38 PM
Our latest work on the #darkgenome is out now in @naturecomms.bsky.social. LINE-1 is the only known autonomous retrotransposon still active in our genome. Co-led by our Alexander Solovyov @MSKCancerCenter - our work was also great collaboration with @rome_tx 👇👇👇
nature.com/articles/s4146
nature.com/articles/s4146
Reposted by Benjamin D. Greenbaum
We’re excited to announce a new publication in Nature Communications: the first large-scale, pan-cancer analysis of LINE-1 expression levels and retrotransposition (RT) activity. These data demonstrate the potential for precision LINE-1 RT-targeted therapeutic approaches. rometx.com/press-releas...
March 3, 2025 at 12:08 PM
We’re excited to announce a new publication in Nature Communications: the first large-scale, pan-cancer analysis of LINE-1 expression levels and retrotransposition (RT) activity. These data demonstrate the potential for precision LINE-1 RT-targeted therapeutic approaches. rometx.com/press-releas...
Reposted by Benjamin D. Greenbaum
An new publication in @Nature by SU2C Convergence Team leaders @thevinodlab.bsky.social @bengrbm.bsky.social @mskcancercenter.bsky.social showed an individualized neoantigen mRNA vaccine for #pancreaticcancer led to prolonged survival and effector T cell responses www.nature.com/articles/s41...
RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer - Nature
In a phase 1 trial, patients with pancreatic ductal adenocarcinoma who were treated with surgery and bespoke neoantigen mRNA vaccines combined with anti-PD-L1 and chemotherapy exhibited marked lo...
www.nature.com
February 20, 2025 at 7:14 PM
An new publication in @Nature by SU2C Convergence Team leaders @thevinodlab.bsky.social @bengrbm.bsky.social @mskcancercenter.bsky.social showed an individualized neoantigen mRNA vaccine for #pancreaticcancer led to prolonged survival and effector T cell responses www.nature.com/articles/s41...
Reposted by Benjamin D. Greenbaum
(1/2) Results from a phase 1 clinical trial of the #mRNA-based therapeutic cancer vaccine autogene cevumeran for treating #pancreaticcancer is published in @nature.com. bit.ly/4b9ofEZ
February 19, 2025 at 6:34 PM
(1/2) Results from a phase 1 clinical trial of the #mRNA-based therapeutic cancer vaccine autogene cevumeran for treating #pancreaticcancer is published in @nature.com. bit.ly/4b9ofEZ
Reposted by Benjamin D. Greenbaum
A new study in @cellpress.bsky.social Immunity from the lab of Dr. Benjamin Greenbaum provides insights into how #PancreaticCancer cells accommodate active retrotransposons without triggering the innate immune response. #oncsky #medsky
Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms
Overexpression of transposable elements is a common feature of cancer. Sun, You, et al.
show that, in pancreatic ductal adenocarcinoma, tumor cells adapt through different
mechanisms to mitigate a spe...
www.cell.com
November 27, 2024 at 6:57 PM
A new study in @cellpress.bsky.social Immunity from the lab of Dr. Benjamin Greenbaum provides insights into how #PancreaticCancer cells accommodate active retrotransposons without triggering the innate immune response. #oncsky #medsky