<p>The <em>Journal of Applied Physiology</em> publishes original papers that deal with diverse areas of research in applied physiology, especially those papers emphasizing adaptive and integrative mechanisms. Adaptive physiology includes 1) inherent adaptations such as those related to development, aging, and pathophysiological conditions and 2) adaptations to the external environment such as those occurring with exercise, microgravity, hypoxia, hypo- and hyperbaria, and hypo- and hyperthermic conditions. Integrative physiology includes 1) horizontal integration across organ systems and 2) vertical integration from molecule to cell to organ. In all areas of applied physiology, the use of cutting-edge techniques including molecular and cellular biology is strongly encouraged.</p><p>The wide scientific span of the Journal rests on physiology as its keystone. However, the boundaries of physiology have enlarged as demarcations between concepts and techniques in the physiological, pharmacological, and biochemical sciences become increasingly blurred. Moreover, theoretical articles on research at any level of biological organization ranging from molecules to humans fall within the broad scope of the Journal. Papers dealing with topics in other basic sciences that impinge on physiology are also welcome.</p>

Introduction: Endurance athletes often utilize low-intensity training, commonly defined as Zone 2 (Z2) within a five-zone intensity model, for its potential to enhance aerobic adaptations and metabol....

Summary: Creatine loading supplementation increases 15s-work while hinting at different mechanisms involved in its effects on individual limitations to 15s-work.