Brooke M. Emerling
@bemerling.bsky.social
Reposted by Brooke M. Emerling
Thrilled to share our first collaboration with @bemerling.bsky.social 🎉 Fantastic work by first author Dr. Gurpreet Arora showing how PI5P4Kα fuels pancreatic cancer cell fitness and reveals a new therapeutic vulnerability. www.cell.com/cell-reports...
PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer
PI5P4Kα is a critical metabolic gatekeeper in PDAC, promoting glucose and iron acquisition
to support tumor survival. Arora et al. demonstrate that PI5P4Kα suppression disrupts
the metabolic flexibili...
www.cell.com
September 2, 2025 at 8:26 PM
Thrilled to share our first collaboration with @bemerling.bsky.social 🎉 Fantastic work by first author Dr. Gurpreet Arora showing how PI5P4Kα fuels pancreatic cancer cell fitness and reveals a new therapeutic vulnerability. www.cell.com/cell-reports...
Reposted by Brooke M. Emerling
New preprint with @bemerling.bsky.social + first author Dr. Preeti Arora: PI5P4Kα supports pancreatic cancer cell survival by maintaining iron. Knockdown disrupts iron homeostasis, triggers apoptosis, and blocks tumor growth. A potential new target.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
PI5P4Kα Regulates Iron Balance to Promote Metabolic Fitness in Pancreatic Cancer
Phosphoinositide kinases generate distinct phosphoinositides that regulate processes that maintain cellular fitness. Phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) have garnered interest for the...
www.biorxiv.org
April 21, 2025 at 2:25 PM
New preprint with @bemerling.bsky.social + first author Dr. Preeti Arora: PI5P4Kα supports pancreatic cancer cell survival by maintaining iron. Knockdown disrupts iron homeostasis, triggers apoptosis, and blocks tumor growth. A potential new target.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Brooke M. Emerling
#REVIEW 🚨
Brooke Emerling & Co @sbpdiscovery.bsky.social @bemerling.bsky.social summarize the roles of phosphatidylinositol 4-kinases #PI4Ks and phosphatidylinositol phosphate kinases #PIPKs in cancer.
📖 ⬇️
Brooke Emerling & Co @sbpdiscovery.bsky.social @bemerling.bsky.social summarize the roles of phosphatidylinositol 4-kinases #PI4Ks and phosphatidylinositol phosphate kinases #PIPKs in cancer.
📖 ⬇️
Phosphoinositide kinases in cancer: from molecular mechanisms to therapeutic opportunities - Nature Reviews Cancer
In this Review, Emerling and colleagues summarize the roles of phosphatidylinositol 4-kinases (PI4Ks) and phosphatidylinositol phosphate kinases (PIPKs) in cancer. They highlight the altered expression of these kinases in tumours and discuss ongoing efforts in developing therapies targeting these lesser-studied phosphoinositide kinase families.
bit.ly
April 16, 2025 at 1:42 PM
#REVIEW 🚨
Brooke Emerling & Co @sbpdiscovery.bsky.social @bemerling.bsky.social summarize the roles of phosphatidylinositol 4-kinases #PI4Ks and phosphatidylinositol phosphate kinases #PIPKs in cancer.
📖 ⬇️
Brooke Emerling & Co @sbpdiscovery.bsky.social @bemerling.bsky.social summarize the roles of phosphatidylinositol 4-kinases #PI4Ks and phosphatidylinositol phosphate kinases #PIPKs in cancer.
📖 ⬇️