Stephen Bell
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bellp450enzyme.bsky.social
Stephen Bell
@bellp450enzyme.bsky.social
Chemist, heme enzyme enthusiast, cytochrome P450 tinkerer.
Great work (and a lot of work) from lead author Lewis. Thanks to all for putting up with me during my stay. Thanks to the University of Adelaide for letting me go for a productive visit to explore #heme #enzyme #catalysis, #crystals and #structures.
October 21, 2025 at 10:14 PM
Reposted by Stephen Bell
Primary @natcomms.nature.com article: "Structural insights into S-lignin O-demethylation via a rare class of heme peroxygenase enzymes" from ‪@bellp450enzyme.bsky.social,‬ ‪@freewhelan.bsky.social‬ and colleagues.

www.nature.com/articles/s41...
Structural insights into S-lignin O-demethylation via a rare class of heme peroxygenase enzymes - Nature Communications
This article demonstrates that native P450 peroxygenases with the in-built machinery for hydrogen peroxide utilisation exist; defines the molecular template for native P450 peroxygenase activity; and ...
www.nature.com
June 12, 2025 at 3:32 PM
Reposted by Stephen Bell
Congratulations to PhD candidate @alixharlington.bsky.social, the driving force behind this research; and thanks to @bellp450enzyme.bsky.social for an enjoyable and productive collaboration. Thanks also to Keith Shearwin for your unflagging support & Tuhin Das for your work characterising mutants.
February 21, 2025 at 12:24 AM
Reposted by Stephen Bell
Thanks to the #ARC and Ramsay fellowship scheme for supporting this research, and to the #AustralianSynchrotron MX beamline staff for keeping our critical infrastructure accessible and productive!
February 21, 2025 at 12:54 AM
Latest work from my HDR students at UoA. A nice study on a self-sufficient thermophilic #P450 fusion protein for selective aromatic #CHbond activation. Thanks to James De Voss (#UQ) and Fiona Whelan (UoA) for their help.
January 22, 2025 at 7:46 AM