Bavarian Center for Biomolecular Mass Spectrometry
@baybioms.bsky.social
Bayerisches Zentrum für Biomolekulare Massenspektrometrie | TUM School of Life Sciences | Proteomics | Metabolomics | Bioinformatics | 🇩🇪
Check out our latest collaborative work with Prof. Martin Stegmann!
A new PRM-based #targeted #proteomics study led by our Head of Proteomics Dr. Christina Ludwig together with doctoral candidate Genc Haliti @genc-haliti.bsky.social.
A new PRM-based #targeted #proteomics study led by our Head of Proteomics Dr. Christina Ludwig together with doctoral candidate Genc Haliti @genc-haliti.bsky.social.
🥳 Thrilled to share my first paper contribution as co-author, published recently in @plos.org #Pathogens, an interdisciplinary collaboration driving discovery in #plant #immunity!
CEPR2 perceives group II CEPs to regulate cell surface receptor-mediated immunity in Arabidopsis
Author summary To protect themselves against pathogens, plants have evolved a sophisticated and intricate immune system that allows pathogen detection and the activation of appropriate defense respons...
journals.plos.org
November 21, 2025 at 10:46 PM
Check out our latest collaborative work with Prof. Martin Stegmann!
A new PRM-based #targeted #proteomics study led by our Head of Proteomics Dr. Christina Ludwig together with doctoral candidate Genc Haliti @genc-haliti.bsky.social.
A new PRM-based #targeted #proteomics study led by our Head of Proteomics Dr. Christina Ludwig together with doctoral candidate Genc Haliti @genc-haliti.bsky.social.
Reposted by Bavarian Center for Biomolecular Mass Spectrometry
🥳 Thrilled to share my first paper contribution as co-author, published recently in @plos.org #Pathogens, an interdisciplinary collaboration driving discovery in #plant #immunity!
CEPR2 perceives group II CEPs to regulate cell surface receptor-mediated immunity in Arabidopsis
Author summary To protect themselves against pathogens, plants have evolved a sophisticated and intricate immune system that allows pathogen detection and the activation of appropriate defense respons...
journals.plos.org
November 21, 2025 at 10:43 PM
🥳 Thrilled to share my first paper contribution as co-author, published recently in @plos.org #Pathogens, an interdisciplinary collaboration driving discovery in #plant #immunity!
Reposted by Bavarian Center for Biomolecular Mass Spectrometry
🌱 As part of the @baybioms.bsky.social #research collaboration, we contributed with #targeted LC-MS/MS using Parallel Reaction Monitoring #PRM to search for endogenous group II CEP signaling peptides in #Arabidopsis.
November 21, 2025 at 10:43 PM
🌱 As part of the @baybioms.bsky.social #research collaboration, we contributed with #targeted LC-MS/MS using Parallel Reaction Monitoring #PRM to search for endogenous group II CEP signaling peptides in #Arabidopsis.
Reposted by Bavarian Center for Biomolecular Mass Spectrometry
November 21, 2025 at 10:43 PM
🎓 PhD Defense at BayBioMS - Congratulations to Dr. Miriam Abele!
We bid farewell to October 2025 - what a month it has been!
And what better way to start November than with great news from our first PhD defense!
We bid farewell to October 2025 - what a month it has been!
And what better way to start November than with great news from our first PhD defense!
November 7, 2025 at 2:48 PM
🎓 PhD Defense at BayBioMS - Congratulations to Dr. Miriam Abele!
We bid farewell to October 2025 - what a month it has been!
And what better way to start November than with great news from our first PhD defense!
We bid farewell to October 2025 - what a month it has been!
And what better way to start November than with great news from our first PhD defense!
Reposted by Bavarian Center for Biomolecular Mass Spectrometry
It was such a pleasure to participate in such a diverse symposium with high quality contributions. And ended perfect with joint bike ride around Freising. Thank you @baybioms.bsky.social
October 25, 2025 at 9:51 AM
It was such a pleasure to participate in such a diverse symposium with high quality contributions. And ended perfect with joint bike ride around Freising. Thank you @baybioms.bsky.social
Reposted by Bavarian Center for Biomolecular Mass Spectrometry
✨ Honored to present my #plant #peptidomics research at the Elite Network of Bavaria on-site project review - in the presence of eminent professors, representatives of the Bavarian State Ministry of Science and the Arts, colleagues, and friends.
October 17, 2025 at 10:33 AM
✨ Honored to present my #plant #peptidomics research at the Elite Network of Bavaria on-site project review - in the presence of eminent professors, representatives of the Bavarian State Ministry of Science and the Arts, colleagues, and friends.
Reposted by Bavarian Center for Biomolecular Mass Spectrometry
Grateful for the inspiring discussions and the opportunity to share how we explore plant peptide dynamics through #mass #spectrometry within our doctoral program “The Proteomes That Feed the World”.
#Peptidomics #MassSpectrometry #PhD #Research #TeamMassSpec
#Peptidomics #MassSpectrometry #PhD #Research #TeamMassSpec
October 17, 2025 at 10:33 AM
Grateful for the inspiring discussions and the opportunity to share how we explore plant peptide dynamics through #mass #spectrometry within our doctoral program “The Proteomes That Feed the World”.
#Peptidomics #MassSpectrometry #PhD #Research #TeamMassSpec
#Peptidomics #MassSpectrometry #PhD #Research #TeamMassSpec
Reposted by Bavarian Center for Biomolecular Mass Spectrometry
🎉 #BayBioMS turns 10! 🎉
Next week, we’re celebrating #10years!
A decade of cutting-edge #MassSpectrometry.
It’s an occasion not to be missed!
We look forward to celebrating with you! 🧪🎈
#TeamMassSpec #Proteomics #Metabolomics #Bioinformatics
Next week, we’re celebrating #10years!
A decade of cutting-edge #MassSpectrometry.
It’s an occasion not to be missed!
We look forward to celebrating with you! 🧪🎈
#TeamMassSpec #Proteomics #Metabolomics #Bioinformatics
🧵(1/7)
🎉 #BayBioMS turns 10! 🎉
2025 marks our 10th anniversary of Mapping Molecular Mountains.
(Final reminder for next week's big anniversary & many thanks to the extended list of new sponsors.)
🎉 #BayBioMS turns 10! 🎉
2025 marks our 10th anniversary of Mapping Molecular Mountains.
(Final reminder for next week's big anniversary & many thanks to the extended list of new sponsors.)
October 15, 2025 at 5:56 AM
🎉 #BayBioMS turns 10! 🎉
Next week, we’re celebrating #10years!
A decade of cutting-edge #MassSpectrometry.
It’s an occasion not to be missed!
We look forward to celebrating with you! 🧪🎈
#TeamMassSpec #Proteomics #Metabolomics #Bioinformatics
Next week, we’re celebrating #10years!
A decade of cutting-edge #MassSpectrometry.
It’s an occasion not to be missed!
We look forward to celebrating with you! 🧪🎈
#TeamMassSpec #Proteomics #Metabolomics #Bioinformatics
🧵(1/7)
🎉 #BayBioMS turns 10! 🎉
2025 marks our 10th anniversary of Mapping Molecular Mountains.
(Final reminder for next week's big anniversary & many thanks to the extended list of new sponsors.)
🎉 #BayBioMS turns 10! 🎉
2025 marks our 10th anniversary of Mapping Molecular Mountains.
(Final reminder for next week's big anniversary & many thanks to the extended list of new sponsors.)
October 15, 2025 at 5:18 AM
🧵(1/7)
🎉 #BayBioMS turns 10! 🎉
2025 marks our 10th anniversary of Mapping Molecular Mountains.
(Final reminder for next week's big anniversary & many thanks to the extended list of new sponsors.)
🎉 #BayBioMS turns 10! 🎉
2025 marks our 10th anniversary of Mapping Molecular Mountains.
(Final reminder for next week's big anniversary & many thanks to the extended list of new sponsors.)
🌄 The tradition continues! 🎉
This year’s #BrixenProteomics #SummerSchool once again exceeded expectations. We welcomed passionate young talents and leading experts from academia and industry for a week filled with science, inspiration, and collaboration. 🔬✨
This year’s #BrixenProteomics #SummerSchool once again exceeded expectations. We welcomed passionate young talents and leading experts from academia and industry for a week filled with science, inspiration, and collaboration. 🔬✨
July 31, 2025 at 10:54 AM
🌄 The tradition continues! 🎉
This year’s #BrixenProteomics #SummerSchool once again exceeded expectations. We welcomed passionate young talents and leading experts from academia and industry for a week filled with science, inspiration, and collaboration. 🔬✨
This year’s #BrixenProteomics #SummerSchool once again exceeded expectations. We welcomed passionate young talents and leading experts from academia and industry for a week filled with science, inspiration, and collaboration. 🔬✨
🎉 BayBioMS turns 10! 🎉
2025 marks our 10th anniversary of Mapping Molecular Mountains.
Thus, we’re excited to invite you to the 10 Years of #BayBioMS #Symposium – a celebration of a decade of accelerating #MassSpectrometry research at the @tum.de!
🧵(1/6)
2025 marks our 10th anniversary of Mapping Molecular Mountains.
Thus, we’re excited to invite you to the 10 Years of #BayBioMS #Symposium – a celebration of a decade of accelerating #MassSpectrometry research at the @tum.de!
🧵(1/6)
July 22, 2025 at 4:36 AM
🎉 BayBioMS turns 10! 🎉
2025 marks our 10th anniversary of Mapping Molecular Mountains.
Thus, we’re excited to invite you to the 10 Years of #BayBioMS #Symposium – a celebration of a decade of accelerating #MassSpectrometry research at the @tum.de!
🧵(1/6)
2025 marks our 10th anniversary of Mapping Molecular Mountains.
Thus, we’re excited to invite you to the 10 Years of #BayBioMS #Symposium – a celebration of a decade of accelerating #MassSpectrometry research at the @tum.de!
🧵(1/6)
🔬 The next BayBioMS Advanced Mass Spectrometry Seminar is happening this Wednesday! 🧪
Doors open at 4:45 PM — free drinks and snacks will be served!
This time, we will highlight cutting-edge work in:
#Phosphoproteomics
(Targeted) #peptidomics
#PTM analysis (#citrullination)
Doors open at 4:45 PM — free drinks and snacks will be served!
This time, we will highlight cutting-edge work in:
#Phosphoproteomics
(Targeted) #peptidomics
#PTM analysis (#citrullination)
July 1, 2025 at 4:38 AM
🔬 The next BayBioMS Advanced Mass Spectrometry Seminar is happening this Wednesday! 🧪
Doors open at 4:45 PM — free drinks and snacks will be served!
This time, we will highlight cutting-edge work in:
#Phosphoproteomics
(Targeted) #peptidomics
#PTM analysis (#citrullination)
Doors open at 4:45 PM — free drinks and snacks will be served!
This time, we will highlight cutting-edge work in:
#Phosphoproteomics
(Targeted) #peptidomics
#PTM analysis (#citrullination)
Reposted by Bavarian Center for Biomolecular Mass Spectrometry
Excited our paper is out in Cell @cp-cell.bsky.social!
🧬⚡ DNA photo-crosslinking proteomics in living cells
🎯 Pinpoints protein-DNA interactions to single amino acids
🌎 Globally quantifies DNA binding for >1800 proteins at a timescale of minutes
🔗 www.cell.com/cell/fulltex...
🧵
🧬⚡ DNA photo-crosslinking proteomics in living cells
🎯 Pinpoints protein-DNA interactions to single amino acids
🌎 Globally quantifies DNA binding for >1800 proteins at a timescale of minutes
🔗 www.cell.com/cell/fulltex...
🧵
The human proteome with direct physical access to DNA
Zero-distance photo-crosslinking reveals direct protein-DNA interactions in living
cells, enabling quantitative analysis of the DNA-interacting proteome on a timescale
of minutes with single-amino-aci...
www.cell.com
May 23, 2025 at 7:06 AM
Excited our paper is out in Cell @cp-cell.bsky.social!
🧬⚡ DNA photo-crosslinking proteomics in living cells
🎯 Pinpoints protein-DNA interactions to single amino acids
🌎 Globally quantifies DNA binding for >1800 proteins at a timescale of minutes
🔗 www.cell.com/cell/fulltex...
🧵
🧬⚡ DNA photo-crosslinking proteomics in living cells
🎯 Pinpoints protein-DNA interactions to single amino acids
🌎 Globally quantifies DNA binding for >1800 proteins at a timescale of minutes
🔗 www.cell.com/cell/fulltex...
🧵
Reposted by Bavarian Center for Biomolecular Mass Spectrometry
UV crosslinking works great for protein-RNA complexes, but DNA is much less photo-reactive and photo-crosslinking not commonly used. Analogous, we find that the photo-activatable nucleotide 4ST (DNA) is about ten times less reactive than the commonly used 4SU (RNA). (1/n)
May 23, 2025 at 7:13 AM
UV crosslinking works great for protein-RNA complexes, but DNA is much less photo-reactive and photo-crosslinking not commonly used. Analogous, we find that the photo-activatable nucleotide 4ST (DNA) is about ten times less reactive than the commonly used 4SU (RNA). (1/n)
Reposted by Bavarian Center for Biomolecular Mass Spectrometry
Unlike natural DNA, 4ST can be activated by wavelengths far outside the absorption range of most natural biomolecules. This avoids photodamage, allowing us to use high-power LEDs, with ~1000-fold higher intensity than conventional bulbs, for activating 4ST in living cells (www.uven.org). (2/n)
May 23, 2025 at 7:13 AM
Unlike natural DNA, 4ST can be activated by wavelengths far outside the absorption range of most natural biomolecules. This avoids photodamage, allowing us to use high-power LEDs, with ~1000-fold higher intensity than conventional bulbs, for activating 4ST in living cells (www.uven.org). (2/n)
Reposted by Bavarian Center for Biomolecular Mass Spectrometry
To analyze protein photo-crosslinked to DNA by proteomics, we develop XDNAX: protein-crosslinked DNA extraction. (3/n)
May 23, 2025 at 7:13 AM
To analyze protein photo-crosslinked to DNA by proteomics, we develop XDNAX: protein-crosslinked DNA extraction. (3/n)
Reposted by Bavarian Center for Biomolecular Mass Spectrometry
XDNAX extracts are very clean and we discover previously elusive peptide-DNA crosslinks within them. They pinpoint protein-DNA interaction sites to individual amino acids. (4/n)
May 23, 2025 at 7:13 AM
XDNAX extracts are very clean and we discover previously elusive peptide-DNA crosslinks within them. They pinpoint protein-DNA interaction sites to individual amino acids. (4/n)
Reposted by Bavarian Center for Biomolecular Mass Spectrometry
In contrast to formaldehyde crosslinking, photo-crosslinking only captures direct interactions (‘zero-distance’). The proteins we find in close proximity to DNA show very high degrees of intrinsic disorder. In fact, intrinsic disorder rises the closer proteins localize to DNA. (5/n)
May 23, 2025 at 7:13 AM
In contrast to formaldehyde crosslinking, photo-crosslinking only captures direct interactions (‘zero-distance’). The proteins we find in close proximity to DNA show very high degrees of intrinsic disorder. In fact, intrinsic disorder rises the closer proteins localize to DNA. (5/n)
Reposted by Bavarian Center for Biomolecular Mass Spectrometry
To identify transcription factors or chromatin modifiers responding to changes in a cell, DNA interactomes can be compared between conditions. Treating breast cancer cells with increasing estrogen doses, we find the estrogen receptor and other regulators recruited to DNA dose-dependently. (6/n)
May 23, 2025 at 7:13 AM
To identify transcription factors or chromatin modifiers responding to changes in a cell, DNA interactomes can be compared between conditions. Treating breast cancer cells with increasing estrogen doses, we find the estrogen receptor and other regulators recruited to DNA dose-dependently. (6/n)
Reposted by Bavarian Center for Biomolecular Mass Spectrometry
This also works in primary cells, where we see recruitment of inflammation-associated transcription factors to DNA in macrophages challenged with LPS. (7/n)
May 23, 2025 at 7:13 AM
This also works in primary cells, where we see recruitment of inflammation-associated transcription factors to DNA in macrophages challenged with LPS. (7/n)
Reposted by Bavarian Center for Biomolecular Mass Spectrometry
We use these quantitative powers to profile three genotoxic drugs and find very distinct reactions in the DNA interactome of cancer cells. This reveals drug-specific vulnerabilities that can be exploited for combination treatments. (8/n)
May 23, 2025 at 7:13 AM
We use these quantitative powers to profile three genotoxic drugs and find very distinct reactions in the DNA interactome of cancer cells. This reveals drug-specific vulnerabilities that can be exploited for combination treatments. (8/n)
Reposted by Bavarian Center for Biomolecular Mass Spectrometry
DNA photo-crosslinking takes 1 minute on ice, while formaldehyde requires 10 minutes at room temperature. We record a time series of photo-crosslinked DNA interactomes during acute BAF inhibition and identify fast-acting restrictors of chromatin accessibility missed by conventional methods. (9/n)
May 23, 2025 at 7:13 AM
DNA photo-crosslinking takes 1 minute on ice, while formaldehyde requires 10 minutes at room temperature. We record a time series of photo-crosslinked DNA interactomes during acute BAF inhibition and identify fast-acting restrictors of chromatin accessibility missed by conventional methods. (9/n)
Reposted by Bavarian Center for Biomolecular Mass Spectrometry
Overall, we present a resource of nearly 50 photo-crosslinked, i.e. direct physical, DNA interactomes and identify 688 peptide-DNA crosslinks. These crosslinks mark known but also unknown protein-DNA interaction sites, some overlapping with variant sites linked to genetic or somatic disease. (10/n)
May 23, 2025 at 7:13 AM
Overall, we present a resource of nearly 50 photo-crosslinked, i.e. direct physical, DNA interactomes and identify 688 peptide-DNA crosslinks. These crosslinks mark known but also unknown protein-DNA interaction sites, some overlapping with variant sites linked to genetic or somatic disease. (10/n)