Philippe Bastin's Lab
@bastinlab.bsky.social
Research unit @Institut Pasteur & @Inserm dealing with trypanosomes, cilia and flagella, tsetse flies, intraflagellar transport, imaging by light and electron microscopy,...
https://research.pasteur.fr/en/team/trypanosome-cell-biology/
https://research.pasteur.fr/en/team/trypanosome-cell-biology/
A full house for the brilliant talk of Jean Popovici (Institut Pasteur du Cambodge) @pasteur.fr bridging #parasitology and #virology #malaria #plasmodium #Pasteur2030
November 4, 2025 at 7:43 AM
A full house for the brilliant talk of Jean Popovici (Institut Pasteur du Cambodge) @pasteur.fr bridging #parasitology and #virology #malaria #plasmodium #Pasteur2030
Great issue! Bonus: includes Daniel's work on incorporation of tagged tubulin in flagella!
October 28, 2025 at 8:55 AM
Great issue! Bonus: includes Daniel's work on incorporation of tagged tubulin in flagella!
Special thanks to our keynote lectures for fantastic talks! @micromotility.bsky.social @mick-lab.bsky.social
October 21, 2025 at 11:39 AM
Special thanks to our keynote lectures for fantastic talks! @micromotility.bsky.social @mick-lab.bsky.social
Many thanks to all participants to the CFC2025 meeting last week for having made it such a vibrant experience! So much exciting research on #cilia
October 21, 2025 at 11:35 AM
Many thanks to all participants to the CFC2025 meeting last week for having made it such a vibrant experience! So much exciting research on #cilia
Outstanding work from Prof Hiroshi Hamada @ncbsbangalore.bsky.social on the contribution of cilia to the definition of left-right asymmetry in multiple organisms, fascinating data on snails. Many thanks to @meilhacsigolene.bsky.social for the organisation @pasteur.fr @institutimagine.bsky.social
September 24, 2025 at 6:56 AM
Outstanding work from Prof Hiroshi Hamada @ncbsbangalore.bsky.social on the contribution of cilia to the definition of left-right asymmetry in multiple organisms, fascinating data on snails. Many thanks to @meilhacsigolene.bsky.social for the organisation @pasteur.fr @institutimagine.bsky.social
Cilai and flagella do better, they have trains and tracks! with #intraflagellar transport
July 17, 2025 at 2:31 PM
Cilai and flagella do better, they have trains and tracks! with #intraflagellar transport
The nucleus is fantastic, but can it beat #cilia and #flagella 😉 here stained for tubulin (magenta) with an intraflagellar transport train (green) after #expansion microscopy and #STED or shown by classic TEM. JCS @jcellsci.bsky.social found the solution and is featuring both! 😍
July 17, 2025 at 9:02 AM
The nucleus is fantastic, but can it beat #cilia and #flagella 😉 here stained for tubulin (magenta) with an intraflagellar transport train (green) after #expansion microscopy and #STED or shown by classic TEM. JCS @jcellsci.bsky.social found the solution and is featuring both! 😍
Discover more about our dear Daniel: journals.biologists.com/jcs/article/...
His paper can be found here
doi.org/10.1242/jcs....
Many thanks to @jcellsci.bsky.social for giving visibility to young scientists!
His paper can be found here
doi.org/10.1242/jcs....
Many thanks to @jcellsci.bsky.social for giving visibility to young scientists!
July 15, 2025 at 6:37 AM
Discover more about our dear Daniel: journals.biologists.com/jcs/article/...
His paper can be found here
doi.org/10.1242/jcs....
Many thanks to @jcellsci.bsky.social for giving visibility to young scientists!
His paper can be found here
doi.org/10.1242/jcs....
Many thanks to @jcellsci.bsky.social for giving visibility to young scientists!
On Friday, Daniel left us after more than 4 happy years in the lab @pasteur.fr and a great paper published today in @jcellsci.bsky.social as well as other contributions!
Many thanks for everything!
journals.biologists.com/jcs/article-...
Many thanks for everything!
journals.biologists.com/jcs/article-...
July 7, 2025 at 12:36 PM
On Friday, Daniel left us after more than 4 happy years in the lab @pasteur.fr and a great paper published today in @jcellsci.bsky.social as well as other contributions!
Many thanks for everything!
journals.biologists.com/jcs/article-...
Many thanks for everything!
journals.biologists.com/jcs/article-...
Wondering about the role of the Leishmania promastigote flagellum at the initiation of infection? It is essential but not via its motile function! Great work by Tom Beneke, Eva Gluenz @albuquerqueafrr.bsky.social and colleagues 👍
www.tandfonline.com/doi/10.1080/...
www.tandfonline.com/doi/10.1080/...
July 7, 2025 at 7:40 AM
Wondering about the role of the Leishmania promastigote flagellum at the initiation of infection? It is essential but not via its motile function! Great work by Tom Beneke, Eva Gluenz @albuquerqueafrr.bsky.social and colleagues 👍
www.tandfonline.com/doi/10.1080/...
www.tandfonline.com/doi/10.1080/...
Beautiful cartoons on the grids of the Institute illustrating our future research centre on vector-borne diseases @pasteur.fr with lovely #trypanosomes and a tsetse fly 😉
Many thanks to Céleste Gangolphe for the exceptional work!
Many thanks to Céleste Gangolphe for the exceptional work!
July 4, 2025 at 11:27 AM
Beautiful cartoons on the grids of the Institute illustrating our future research centre on vector-borne diseases @pasteur.fr with lovely #trypanosomes and a tsetse fly 😉
Many thanks to Céleste Gangolphe for the exceptional work!
Many thanks to Céleste Gangolphe for the exceptional work!
Wonderful time at our PIV departmental retreat @pasteur.fr, congratulations to @chrisgirardb.bsky.social and her dream team @fernando-batista.bsky.social, Francisco Martinez-Blazquez and Marcela Fuentes Carias for the organisation! And a great vision talk by Daniel 👍
June 27, 2025 at 8:51 PM
Wonderful time at our PIV departmental retreat @pasteur.fr, congratulations to @chrisgirardb.bsky.social and her dream team @fernando-batista.bsky.social, Francisco Martinez-Blazquez and Marcela Fuentes Carias for the organisation! And a great vision talk by Daniel 👍
Nice experience at The Conduit discussing the impact of climate change on vector-borne diseases. Many thanks to all involved in the organisation, my fellow panelists @charlottekilpo.bsky.social @samiasaad.bsky.social @mcdonnell.bsky.social @ellenthoen.bsky.social and the UK Pasteur foundation
June 25, 2025 at 6:51 AM
Nice experience at The Conduit discussing the impact of climate change on vector-borne diseases. Many thanks to all involved in the organisation, my fellow panelists @charlottekilpo.bsky.social @samiasaad.bsky.social @mcdonnell.bsky.social @ellenthoen.bsky.social and the UK Pasteur foundation
Great science yesterday at the @ibeidlabex.bsky.social meeting at ENVA at Maisons Alfort with fantastic talks from our guest @drrachellowe.bsky.social and many others! @salehlabparis.bsky.social @fernando-batista.bsky.social @pasteur.fr @anses-fr.bsky.social @inserm.fr @ap-hp.bsky.social
June 17, 2025 at 2:10 PM
Great science yesterday at the @ibeidlabex.bsky.social meeting at ENVA at Maisons Alfort with fantastic talks from our guest @drrachellowe.bsky.social and many others! @salehlabparis.bsky.social @fernando-batista.bsky.social @pasteur.fr @anses-fr.bsky.social @inserm.fr @ap-hp.bsky.social
Daniel's paper is now published in @jcellsci.bsky.social, great experience with @reviewcommons.org 😀
Want to know everything tubulin assembly in trypanosome flagella and other microtubules? Here is the link:
journals.biologists.com/jcs/article/...
Want to know everything tubulin assembly in trypanosome flagella and other microtubules? Here is the link:
journals.biologists.com/jcs/article/...
June 12, 2025 at 8:49 AM
Daniel's paper is now published in @jcellsci.bsky.social, great experience with @reviewcommons.org 😀
Want to know everything tubulin assembly in trypanosome flagella and other microtubules? Here is the link:
journals.biologists.com/jcs/article/...
Want to know everything tubulin assembly in trypanosome flagella and other microtubules? Here is the link:
journals.biologists.com/jcs/article/...
Honoured to have been introduced today by former lab member @ebertiaux.bsky.social at the annual Microbiology day of New Aquitaine. My first talk in a (former) church!
May 27, 2025 at 8:01 PM
Honoured to have been introduced today by former lab member @ebertiaux.bsky.social at the annual Microbiology day of New Aquitaine. My first talk in a (former) church!
Fantastic #ChoanoCon2025 meeting with choanoflagellates and multiple fascinating protists! Meeting again choanoflagellate legend Barry Leadbeater 27 years later was emotional! And awarding a baguette for best talk was something 😂
Many thanks to @thibautbrunet.bsky.social for perfect organisation 👏👏👏
Many thanks to @thibautbrunet.bsky.social for perfect organisation 👏👏👏
May 23, 2025 at 6:32 AM
Fantastic #ChoanoCon2025 meeting with choanoflagellates and multiple fascinating protists! Meeting again choanoflagellate legend Barry Leadbeater 27 years later was emotional! And awarding a baguette for best talk was something 😂
Many thanks to @thibautbrunet.bsky.social for perfect organisation 👏👏👏
Many thanks to @thibautbrunet.bsky.social for perfect organisation 👏👏👏
Dear cilia researchers, join us in the heart of the beautiful Vosges mountains to share your latest findings! This year, partnership with @for5547.bsky.social and keynote lectures by @micromotility.bsky.social and @mick-lab.bsky.social
Registration is now open www.cfc2025.conferences-pasteur.org
Registration is now open www.cfc2025.conferences-pasteur.org
April 14, 2025 at 8:42 AM
Dear cilia researchers, join us in the heart of the beautiful Vosges mountains to share your latest findings! This year, partnership with @for5547.bsky.social and keynote lectures by @micromotility.bsky.social and @mick-lab.bsky.social
Registration is now open www.cfc2025.conferences-pasteur.org
Registration is now open www.cfc2025.conferences-pasteur.org
Happy moments ahead of Mark Carrington special symposium tomorrow @uniofcam.bsky.social
March 23, 2025 at 11:46 PM
Happy moments ahead of Mark Carrington special symposium tomorrow @uniofcam.bsky.social
Thanks to a new mass spec pipeline for analysis of the #tubulin tail, the team of Julia Chamot-Rooke and Mariette Matondo revealed a few surprises for #trypanosome beta-tubulin:
-a new glutamylation site
-far less exhaustive detyrosination
Preprint here:
www.biorxiv.org/content/10.1...
-a new glutamylation site
-far less exhaustive detyrosination
Preprint here:
www.biorxiv.org/content/10.1...
March 4, 2025 at 8:07 AM
Thanks to a new mass spec pipeline for analysis of the #tubulin tail, the team of Julia Chamot-Rooke and Mariette Matondo revealed a few surprises for #trypanosome beta-tubulin:
-a new glutamylation site
-far less exhaustive detyrosination
Preprint here:
www.biorxiv.org/content/10.1...
-a new glutamylation site
-far less exhaustive detyrosination
Preprint here:
www.biorxiv.org/content/10.1...
I forgot to say that the tagged tubulin incorporates very well in the spindle, here after a 4-hour induction (green, magenta is axoneme + transition zone). However, we could not see a defined polarity, in contrast to flagellar or cortical microtubules.
February 13, 2025 at 7:35 AM
I forgot to say that the tagged tubulin incorporates very well in the spindle, here after a 4-hour induction (green, magenta is axoneme + transition zone). However, we could not see a defined polarity, in contrast to flagellar or cortical microtubules.
We propose a model where the new flagellum grows in a linear manner while the old one is locked but shrinks slightly, hence requiring unlocking and compensation after cell division, leading to such multicoloured flagella following induction/deinduction/reinduction of tagged tubulin 😉
February 11, 2025 at 8:54 AM
We propose a model where the new flagellum grows in a linear manner while the old one is locked but shrinks slightly, hence requiring unlocking and compensation after cell division, leading to such multicoloured flagella following induction/deinduction/reinduction of tagged tubulin 😉
Data confirmed with Halo-tag tagging of radial spoke proteins, experiment performed by our collaborator Vladimir Varga @czechacademy.bsky.social
Always reinsuring to reach the same conclusion with orthogonal techniques!
Always reinsuring to reach the same conclusion with orthogonal techniques!
February 11, 2025 at 8:54 AM
Data confirmed with Halo-tag tagging of radial spoke proteins, experiment performed by our collaborator Vladimir Varga @czechacademy.bsky.social
Always reinsuring to reach the same conclusion with orthogonal techniques!
Always reinsuring to reach the same conclusion with orthogonal techniques!
Surprise! Some incorporation takes place in old flagella inherited after cell division!
February 11, 2025 at 8:54 AM
Surprise! Some incorporation takes place in old flagella inherited after cell division!